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Measurement of serum Inhibin B as a predictive evaluation of ovarian response following ovulation induction program in intrauterin insemination
قياس هورمون الانهيبين (ب) في مصل الدم كمقياس تقييمي لتخمين استجابة المبايض في برامج تحفيز الاباضة المستخدمة في التقنيات المساعدة على الانجاب

Authors: ليلى خضر غالب --- نوال خيري
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2012 Volume: 2 Issue: 4 Pages: 34-39
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:The evaluation of ovarian reserve has been, and still, the focus of substantial clinical research. The assessment of ovarian reserve is valuable for determining stimulation protocols, and because of limited predictive value of age alone, or other passive hormonal analysis in estimating response to the exogenous stimulation, Dynamic research was done on serum inhibin B.Objective:Measurement of serum inhibin B as a predictive evaluation of early ovarian response following ovulation induction program in intrauterine insemination(IUI).Materials and Methods:Thirty couples were involved in IUI program. They divided into two groups: group (1) 15 women were treated by Gonadotropin(Gn) recombinant follicle -stimulating hormone (rFSH). While group (2), 15 women were treated by Clomiphene citrate (CC). Treatment started at day 3 of the menstrual cycle. Serial hormonal profile tests namely; inhibin B, Estadiol (E2), Follicle-stimulating hormone (FSH), Luteinizing hormone (LH) were done at days 3, 7 of the menstrual cycle and the day of human chorionic gonadotropin hormone (hCG) injection with recurrent ultrasonograghy (U/S) to confirm the number and development of the follicles.Results:There was a significant difference in the level of inhibin B (P< 0.05) between day3 and 7 of the cycle with the mean of the follicle number 1.67± 0.18 in group(1), while in group (2) there was a non significant difference (P>0.05) in the level of inhibin B between day 3 and 7 of the cycle with the mean of the follicle number 2.14 ±0.17. Percentage of pregnancy rate in IUI in this study was 19.23Z.Percentage of pregnancy rate in group (1) was 25% .while in group (2) was 14.28% ,but there is a significant difference (P<0.05) in the pregnancy rate between the two groups.Conclusion:It was concluded that serum irihibin B obtained at day 7(day 5 of (Gn) therapy) offers an early and accurate prediction of ovarian response to (Gn) stimulation while there was no significant change in the level of inhibin B between day 3 and 7 of the cycle in patients treated by CC .

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