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Article
Effect of lead exposure on the development of polycystic ovary syndrome
تاثير الرصاص في نشوء مرض تكيس المبايض

Author: نوال خيري حسين
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2011 Volume: 1 Issue: 1 Pages: 23-30
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

BackgroundThe effects of Lead and other essential metal like zinc and copper on the reproductive system have been previously reviewed.ObjectiveOur goal in this study was to estimate the levels of Lead, Zinc and Copper in patients with polycystic ovary syndrome and to confirm the effect of such metals on the female reproductive system at environmental exposureMaterials and MethodFifty two women in their reproductive age (20-40) years old, which had been diagnosed as PCQS. Venous blood sample were taken from each patient and control, blood lead, zinc and copper were determined by atomic absorption spectrophotometerHormone assay were determined by ELISA (Enzyme Linked Immune Sorbet Assay) technique.ResultsThis study showed a significant increase of blood lead and serum zinc, copper (p<0.01),jn addition to testosterone, lutenizing hormone, LH/FSH ratio and body mass index (BMI) (p<0.05) in patients with polycystic ovary syndrome when compared with control.ConclusionsOn the basis of the observations of the present study, it can conclude that the increased levels of Lead as a result of the exposure to this metal may be a risk factor for the development of polycystic ovary syndrome in women and has adverse effects on female endocrine and reproductive function,

Keywords

Infertility --- PCOS --- Uad --- Zinc --- Copper


Article
Measurement of serum Inhibin B as a predictive evaluation of ovarian response following ovulation induction program in intrauterin insemination
قياس هورمون الانهيبين (ب) في مصل الدم كمقياس تقييمي لتخمين استجابة المبايض في برامج تحفيز الاباضة المستخدمة في التقنيات المساعدة على الانجاب

Authors: ليلى خضر غالب --- نوال خيري
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2012 Volume: 2 Issue: 4 Pages: 34-39
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:The evaluation of ovarian reserve has been, and still, the focus of substantial clinical research. The assessment of ovarian reserve is valuable for determining stimulation protocols, and because of limited predictive value of age alone, or other passive hormonal analysis in estimating response to the exogenous stimulation, Dynamic research was done on serum inhibin B.Objective:Measurement of serum inhibin B as a predictive evaluation of early ovarian response following ovulation induction program in intrauterine insemination(IUI).Materials and Methods:Thirty couples were involved in IUI program. They divided into two groups: group (1) 15 women were treated by Gonadotropin(Gn) recombinant follicle -stimulating hormone (rFSH). While group (2), 15 women were treated by Clomiphene citrate (CC). Treatment started at day 3 of the menstrual cycle. Serial hormonal profile tests namely; inhibin B, Estadiol (E2), Follicle-stimulating hormone (FSH), Luteinizing hormone (LH) were done at days 3, 7 of the menstrual cycle and the day of human chorionic gonadotropin hormone (hCG) injection with recurrent ultrasonograghy (U/S) to confirm the number and development of the follicles.Results:There was a significant difference in the level of inhibin B (P< 0.05) between day3 and 7 of the cycle with the mean of the follicle number 1.67± 0.18 in group(1), while in group (2) there was a non significant difference (P>0.05) in the level of inhibin B between day 3 and 7 of the cycle with the mean of the follicle number 2.14 ±0.17. Percentage of pregnancy rate in IUI in this study was 19.23Z.Percentage of pregnancy rate in group (1) was 25% .while in group (2) was 14.28% ,but there is a significant difference (P<0.05) in the pregnancy rate between the two groups.Conclusion:It was concluded that serum irihibin B obtained at day 7(day 5 of (Gn) therapy) offers an early and accurate prediction of ovarian response to (Gn) stimulation while there was no significant change in the level of inhibin B between day 3 and 7 of the cycle in patients treated by CC .


Article
Evaluation of PSA tumor marker in some Iraqi women with polycystic ovarian syndrome.
تقييم المستضد البروستاتي النوعي لدى بعض النساء العراقيات المصابات بمتلازمة تكيس المبيض المتعدد

Authors: زينب فائق رزيج --- نوال خيري العاني
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2012 Volume: 2 Issue: 4 Pages: 22-24
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Polycystic ovarian syndrome (PCOS) is the most common cause of hyperandrogenism anovulatory infertility; it affects 5-10% female reproductive age.The present study aims to investigate the total prostate specific antigen levels, total serum testosterone, FSH and LH in women with PCOS and compare the results with control group of normal fertile females of corresponding age group on Iraqis PCOS patients.Materials and Methods:Seventy patients with PCOS diagnosed depending on three criteria: Menstrual history: Oligomenorrhea, Ultrasound reveals polycystic ovaries and Biomedical and I or clinical hyperandrogenism.Twenty normal fertile females who serve as control group in this study. Blood samples were aspirated from all individuals from 24- day of menstrual cycle to measure total prostate specific antigen(PSA), total testosterone and FSH, LH .Results:Patients with PCOS and controls differed significantly in PSA, Total serum testosterone (p<0.05). Patients with PCOS and controls have highly significant difference in LH level, the mean was (7.88+ 1.83 vs 3.90+ 0.73) respectively (p<0.001 )and, highly significant difference in LH/FSH ratio and BMI parameters. (p<0.001). No significant differences were found in FSH (p>0.05). Positive correlation between PSA and testosterone, PSA and BMI. Conclusion:Total serum prostate specific antigen levels are higher in patient with PCOS.Total testosterone levels are higher in patient with PCOS.Serum PSA measurement might be marker of hyperandrogenism in females suffering from PCOS.


Article
Environmental lead contamination in relation to semen quality
تاثير التلوث البيئي بالرصاص على العقم الذكري

Authors: نوال خيري حسين --- اسامة سلمان الناصري --- سجى فاروق فيصل
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2011 Volume: 1 Issue: 2 Pages: 25-30
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Semen quality is a measure of the ability of semen to accomplish fertilization. Semen quality involves both sperm quantity and quality.The general population is exposed to metals at low concentrations either voluntarily through supplementation or involuntarily through intake of contaminated food and water or contact with contaminated soil, dust, or air. Some metals, such as lead (Pb), are nonessential xenobiotics that can be measured in most of Ihe general population.objectiveOur goal in this study is to assess relationships between exposure to lead at environmental levels and human semen-quality parameters.materials and methods:The study populatoins consist of 31 infertile male of general population who are occupational^ unexposed to lead and another 26 heal% fertile male as control groupBlood lead and seminal plasma lead measurements performed by Ihe electrothermal-atomic absorption spectrometry (AAS) method. Macroscopic and microscopic examination of semen performed according to WHO recommendations. Seminal plasma separated from ihe spermatozoa by centerfugation and stored at -20°C until required for analyses.ResultsThis study showed significant increase in seminal plasma lead mean value in moderate and severe oligozoospermic infertile males than in fertile male controls(p<0,05) The result also showed no statistically significant difference in blood lead concentration among the infertile group compared to fertile controls.conclusoinsThe results of this study indicate that even moderate exposure to Pb at environmental level [blood Pb < 400 can significantly reduce reproductive capacity in men


Article
A COMPARATIVE STUDY OF FRUCTOSE, ZINC AND COPPER LEVELS IN SEMINAL PLASMA IN FERTILE AND INFERTILE MEN

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Abstract

Background: Human semen contains high concentrations of fructose, zinc (Zn) and copper (Cu) in bound and ionic forms for Zn and Cu. The presence of abnormal levels of fructose and those trace elements may affect spermatogenesis with regard to production, maturation, motility and fertilizing capacity of the spermatozoa.Objective: To evaluate the levels of fructose, Zn and Cu in seminal plasma in different groups of male infertility and to correlate their concentrations with various sperm parameters.Methods: The concentrations of fructose, Zn and Cu were measured in 114 semen samples from normozoospermic, oligozoospermic, astheno-zoospermic, and azoospermic men using the electrothermal-atomic absorption spectrometry for Zn and Cu determination. The concentration of fructose in seminal plasma was determined with a spectrophotometric method, using the resorcinol method.Results: Results of the present study showed that there was an inverse relationship between fructose levels and sperm count. The mean value of seminal plasma fructose concentrations was significantly increased (p ≤ 0.001) in the three groups of infertile male subjects (azoospermia, asthenozoospermia and oligozoospermia) than in fertile males. The mean value of seminal plasma Zn concentrations was significantly decreased (p ≤ 0.001) in the three groups of infertile male subjects (azoospermia, asthenozoospermia and oligozoospermia) than in fertile males. A good correlation in a positive direction was noted between the sperm count and seminal plasma Zn concentration. There was significant decrease in seminal plasma Cu concentration between asthenozoospermia and control groups (p ≤ 0.05) and insignificant increase in oligozoospermic patients.Conclusions: On the basis of the observations of the present study, seminal fructose, zinc and copper may contribute to fertility through their effects on various semen parameters.Key words:Male infertility, fructose, zinc, copper.

Keywords

Male infertility --- fructose --- zinc --- copper

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