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Article
Theoretical study of the Structural and Electronic Properties of the Phenol, PhenoxyPhenol-water complex and Phenoxy-water complex

Authors: Sadiq M. Asmaeel --- Kawkab A. H. Al-ali
Journal: JOURNAL OF THI-QAR SCIENCE مجلة علوم ذي قار ISSN: 19918690 Year: 2011 Volume: 3 Issue: 1 Pages: 89-98
Publisher: Thi-Qar University جامعة ذي قار

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Abstract


Abstract

The theortical calculations of phenol, phenoxy, phenol-water complex, phenoxy-water complex (I, II, III, IV) were studied by quantum chemical calculations. The optimized structures of the compounds were obtained by the Density functional theory (DFT) in gas phase at B3LYP / 6-311G (d, p) & MP2 / 6-311G (d, p) level of theory. The study shown that the value of total energy for compound (II) has much more energy and accordingly less stability in comparison with the compound (I), the compound III (phenol-complex) and compound IV (pheoxy-complex), have more stable structure than compounds ( I, II ). In addition we calculated the HOMO-LUMO, energy gap and system properties such as ionization potential (I), hardness (η), electronegetivity(X), electrophilicity (ω). The calculation interaction energies show that the compound (IV) showed larger energy than compound (III). All calculations was carried out for (I, II, III, IV) and shows the favorable state for stabilities (more stable) (I>II, III>IV).
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KeyWord: Phenol, Phenoxy, Intermolecular Hydrogen Bonding (IHB), DFT, MP2.

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Article
Pre- and post-pubertal Upregulation of testicular IGF-1 gene using passive immunization against inhibin α subunit in neonate rats

Authors: Jabber A. A. Al-Sa'aidi جبارعباس احمد --- Mohammed-Salih محمد صالح --- A. H. Al-Ali
Journal: Al-Qadisiyah Medical Journal مجلة القادسية الطبية ISSN: 18170153 Year: 2014 Volume: 10 Issue: 17 Pages: 11-27
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

The present study has been conducted to evaluate the effect of neonatal passive immunization against inhibin α subunit on testicular mRNA expression level of IGF-1 gene during prepubertal and pubertal stage in male rats. Thirty male rats (weighted 21.5±1.32 g, aged 15 days) were randomly assigned into two equal groups; antiserum treated and control groups, received inhibin-α antiserum (100µl of physiological saline containing 1µg antiserum, i.p.) and physiological saline (100µl, i.p.) at the 15th and 18th days old. Five males from each group were sacrificed at the 23th, 30th and 50th days old. Testis samples were obtained for evaluation of mRNA expression level of IGF-1 gene using RT- PCR. Testis of 50d treated male rats showed higher expression level of IGF-1 gene compared with control, while 23d and 30d showed insignificant changes between studied groups. In conclusion, passive immunization against endogenous circulating inhibin during prepubertal age can perform potent role in testicular functional status and performance in the males after puberty.

أجريت الدراسة الحالية لتقييم تأثير التمنيع الميسر ضد الانهبين ألفا في ذكور الجرذان حديثة الولادة على مستوى استنساخ جين IGF-1 في الخصى في مرحلتي قبل وبعد البلوغ. تم تقسيم 30 جرذا ذكرا حديث الولادة، بعمر 15 يوما ومعدل وزن 31.5 ± 1.32 غم، عشوائيا على مجموعنين متساويتين حقنت الاولى (المعاملة) بالمصل المضاد للانهبين ألفا (100 مايكرلتر من المحلول الفسلجي الحاوي على 1غم من المصل المضاد في البريتون) وحقنت الثانية (السيطرة) بالمحلول الفسلجي (100 مايكرولتر في البريتون) بعمر 15 و18 يوم. خمسة ذكور من كل مجموعة تمت التضحية بها بعمر 23 و 30 و 50 يوم، وأخذت منها الخصى لتقدير مستوى استنساخ جين IGF-1 باستخدام تقانة RT-PCR. أظهرت النتائج أن خصى ذكور جرذان المعاملة بعمر 50 يوما تضاعف فيها استنساخ جين IGF-1 بشكل ملموس احصائيا عند المقارنة مع السيطرة، في حين كانت النتائج غير معنوية بين المجموعتين في خصى الذكور بعمر 23 و 30 يوما. يستنتج من الدراسة الحالية أن التمنيع الميسر ضد الانهبين الداخلي في ذكور الجرذان حديثة الولادة يمكن أن يؤدي دورا فاعلا في مستوى وظيفة وكفاءة الخصى بعد البلوغ.

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