research centers


Search results: Found 3

Listing 1 - 3 of 3
Sort by

Article
Isolation, Purification, And Selection Criteria Of Probiotic Bacteeria “Lactobacillus Jensenii

Author: Abbas Fadhil Hassoon
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2012 Volume: 5 no 1 Issue: 11 Pages: 1211-1218
Publisher: Kerbala University جامعة كربلاء

Loading...
Loading...
Abstract

lactobacilli isolated from stool samples of healthy infants aged 2-28 days were identified as Lactobacillus jensenii based on its morphological description on MRS agar and blood agar, Gram stain, catalase test, and results of API 20 A system . The Lactobacilli were assessed for characteristics considered important for in vitro resistance ability to low pH ( 3,4,5, and 6 ), and resistance ability to different bile salt concentrations 0.5%,1%,1.5%,2%,2.5%, and 3% ). The 'other characteristics studiedwere culture and sensitivity of probiotic bacteria to different types of antimicrobial and antibiotics. The probiotic bacteria revealed inhibitory activities against several pathogenic bacteria (Staphylococus aureus, Streptococcus agalactia, Clostridium perifrenges, Pseudomonas aeroginosa, Escherichia coli, Klebsiella pneumonia,'Salmonella typhi, Vibrio cholerae, and Shigella flexneri ):. Lactobacillus jensenii alsoexhibited its ability for attachment to epithelial cells of human intestine (in vitro).

Keywords


Article
Evaluation of Leukemia Inhibitory Factor, Interleukin6 and Leptin in Acute and Chronic Myeloid Leukemia in Babylon Province

Authors: Dheyaa Jabbar Yahya --- Zainab Wahab Al- Maaroof --- Abbas Fadhil Hassoon
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2016 Volume: 13 Issue: 2 Pages: 513 -521
Publisher: Babylon University جامعة بابل

Loading...
Loading...
Abstract

Leukemias are a group of diseases described by augmented numbers of white cells in the blood and bone marrow as a result of unregulated clonal proliferation of immature malignant cells .These abnormal white blood cells that not completely developed are called (blasts), or (leukemia cells), The diagnosis of Leukemia was confirmed by blood investigation and by bone marrow biopsy. Leukemia inhibitory factor may play an important role, along with Interleukin-6 and granulocyte colony stimulating factor , in the regulation of early hematopoietic stem cells. Leptin has been implicated in the differentiation and proliferation of hematopotietic cells. In this case control study, we evaluate, the levels of LIF, IL6, Leptin in serum of patients with myeloid leukemia and assess the relationship between leptin level & body mass index in myeloid leukemic patients, in the current study involved 96 individuals; 48 patients with myeloid leukemia and 48 controls. Leukemia inhibitory factor, Interleukin 6 and Leptin levels are measured by ELISA assay in both patient and control groups.The mean LIF,Il6 in the AML and CML groups were significantly higher than control group (p<0.05). while Leptin in the AML and CML groups was significantly lower than control group (p<0.05).And the mean (BMI)in the AML and CML groups were significantly lower than control group (p<0.05).In this study, we conclude thatLIF, IL6 and Leptin play an important role in pathogenesis of Leukemia, LIF, IL6 levels in myeloid leukemic patients more than controls while Leptin level in myeloid leukemic patients less than controls and There is significant relationship between Leptin and body mass index.


Article
Immunohistochemical Expression of Hypoxia-Inducible Factor-1α in Triple Negative Breast Cancer

Authors: Mahdi Jassim Muhammad Ali --- Haider Abdul Ridha AL-Khafaji --- Abbas Fadhil Hassoon
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 4 Pages: 902 -915
Publisher: Babylon University جامعة بابل

Loading...
Loading...
Abstract

Triple-negative breast cancer is a malignant neoplasm characterized by absent expression of estrogen, progesterone and human epidermal growth factor-2 receptors. Hypoxia-inducible factor-1 alpha is up-regulated under hypoxia and associated with induction of angiogenesis resulting in proliferation, aggressive tumor phenotype and metastasis. Determination of the potential role of Hypoxia-inducible factor-1 alpha in the development and conventional clinicopathologic factors, and to demonstrate their prognostic relevance in Triple-negative breast cancer. A pro and retrospective study of 281 female patients with breast cancer. The fifty four triple-negative breast cancer formalin-fixed, paraffin-embedded Specimenspresented from all cases were immuno-stained by Hypoxia-inducible factor-1 alpha Immunohistochemical marker. The age groups distributed from 23-85 years old, mean age 51.23±11.26 years. Overall cases, triple negative breast cancer presented in 19.2%; most frequently younger,grade III, tumor size ≥ 2 cm, and positive lymph node metastasis or recurrent more than other subtypes. Hypoxia-inducible factor-1 alpha expression was strongly associated and significantly differentwith grade (p=0.001), lymph node metastasis (p<0.001) and Ki-67 expression (p=0.003). Detected Hypoxia-inducible factor-1 alpha expression has an important role in pathogenesis, drug resistance and in uncontrolled proliferation cells or as important conductor of the worst prognosis in triple negative-breast cancer.

Listing 1 - 3 of 3
Sort by
Narrow your search

Resource type

article (3)


Language

English (2)

Arabic and English (1)


Year
From To Submit

2016 (1)

2015 (1)

2012 (1)