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Article
Atrial natriuretic peptide in chronic renal failure on maintenance hemodialysis : effect of heart failure

Author: Abdul-Aziz A. Aziz عبد العزيز
Journal: Annals of the College of Medicine Mosul مجلة طب الموصل ISSN: 00271446 23096217 Year: 2005 Volume: 31 Issue: 1 Pages: 32-36
Publisher: Mosul University جامعة الموصل

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Abstract

objective: To examine the plasma level of atrial natriuretic peptide(ANP) in patients with
chronic renal failure (CRF) undergoing maintenance hemodialysis ( HD) and to evaluate the
effect of superimposed cardiac functional impairment on the plasma level of this hormone.
Design: A case- series study
Setting: Artificial Kidney and Dialysis Unit of lbn-Sena Teaching Hospital, Mosul; during the
period from June 2003 to August 2004.
Participants: Forty patients with CRF undergoing maintenance HD, were divided into 2 groups depending on presence or absence of heart 6itu[. Group l, includes 20 patients with CRF who did not have heart failure and group Il, includes 20 patients with CRF who had heart failure, The study also includes 20 healthy volunteers as a control group.
Methods: Plasma ANP, serum creatinine, urea and body weights were measured in CRF
patients before and after HD. The same parameters were also measured in the control group.
The paired-t-test was used to examine the difference in the mean of the studied parameters in patients with CRF before and after HD. The unpaired -t- test was used to assess the difference in the mean of the above-mentioned parameters between patients and control group. Pearson correlation coefficient was used to study the relation of the means of differences between pre and post dialysis values of the studied parameters within each patient group.
Results: The mean of plasma ANP level was significantly higher in group I (p<0.0001) and
group ll (p<0.0001) than that in the control group before and after HD. Furthermore, the plasma ANP in group ll was significantly higher (p<0.0001) than that in group I. There was a significant decrease in the plasma ANP in group I (pconclusion: Periodic measurement of plasma ANP level in patients with CRF may be of great
value in evaluating the actual fluid status in patients having CRI and in determination of
frequency and duration of dialysis sessions. lt also may be of value in predicting cardiac
dysfunction in patients with CRF.
Key words: Atrial natriuetic peptide, chronic renal failure, haemodialysis.


Article
Plasma level of atrial natriuretic peptide during normal pregnancy and preeclampsia

Author: Abdul-Aziz A. Aziz عبد العزيز احمد عزيز
Journal: Annals of the College of Medicine Mosul مجلة طب الموصل ISSN: 00271446 23096217 Year: 2005 Volume: 31 Issue: 1 Pages: 1-5
Publisher: Mosul University جامعة الموصل

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Abstract

objective: To assess plasma atrial natriuretic peptide (ANP) level in pregnant and
preeclamptic women, and to evaluate the role of this hormone in the defense mechanism
against body fluids and electrolytes disorders encountered under such physiological
and pathophysiological conditions.
Design: A case- series study.
Setting: Al - Batool Teaching Hospital for Gynecology and Obstetrics, Mosul, during the period from December 2003 to September 2004.
Participants: Twenty five women with normal pregnancy (group I ), 25 pregnant women with
preeclampsia (group ll ) and 25 healthy non pregnant women (control group) were included in this study.
Methods: Plasma ANP, serum creatinine, urea, sodium and potassium were measured in all
groups. unpaired -t-test was used to examine the difference in the mean of the studied
parameters between different groups. Pearson correlation was used to assess the relation
between different parameters within each group.
Results: The mean of plasma ANP level was significantly higher in group I (p<0.05) and group
ll (p<0.0001) than that in the control group. Furthermore, the plasma ANP level was
significantly higher in group ll (p<0,0001) than that in group l. The mean of serum creatinine
and serum urea were significantly higher in group ll than that in group l (p<0.005 and p<0.0001) and control group (p<0.0001 and p<0.0001).
Conclusion: The results of this study indicate that plasma ANP level significantly increases
during pregnancy especially among those who develop preeclampsia. Since ANP plays an
important role in the maintenance of body fluids and electrolytes homeostasis and blood
pressure regulation, estimation of plasma ANP level may be of value in better understanding
and management of pathophysiological conditions that challenge the body homeostatic
mechanisms during pregnancy.
Key words: Atrial natriuretic peptide, preeclampsia.


Article
Effect of Hemodialysis On Plasma Osmolarity In Patients WithChronic Renal Failure

Authors: Yihia Mousa Al-Sunbly --- Abdul- Aziz A. Aziz --- Yesar M.H. Al-Shamma
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2008 Volume: 50 Issue: 2 Pages: 184-186
Publisher: Baghdad University جامعة بغداد

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Abstract


Back ground: The study was conducted on fifty patients (27 males and 20 females)
with chronic renal failure (CRF) undergoing maintenance hemodialysis (HD), at
artificial Kidney unit, Al- Hakeem Hospital / Najaf, during the perioed from April
to June 2008.
Patients & methods: Plasma osmolarity ( Posm), plasma creatinine (P cr ) plasma
urea (P urea)>plasma sodium (P Na)and plasma potassium ( P k )were measured for
all patients before and after dialysis.
Results: The paired t -test was used to compare the pre-dialysis values with the
post dialysis values and simple linear correlation to study the relation between (P
Na), and ( Posm), p values less than 0.05 considered not significant. The result of
study showed a significant decrease in the means of P Na , P k, P cr, P urea and Posm
after dialysis in comparison with the pre-dialysis values ( p<0.0001). There was
also a significant positive correlation between P Na and Posm (r=0.30,p<0.05)
Conclusions: HD had a significant regulatory effect on body fluids and electrolytes
ratio,Posm and removal of uremic toxins in patients with CRF, the study also reviled
that Posm may be another useful indicator of body fluids and electrolytes status
among these patients


Article
Pituitary-gonadal dysfunction in uremic men on maintenance hemodialysis

Authors: Lyla A. Al-mwla ليلى المولى --- Eman A. Hadi ايمان هادي --- Abdul-Aziz A. Aziz
Journal: Annals of the College of Medicine Mosul مجلة طب الموصل ISSN: 00271446 23096217 Year: 2005 Volume: 31 Issue: 2 Pages: 93-96
Publisher: Mosul University جامعة الموصل

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Abstract

Objective: To examine serum prolactin (PRL), luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels in male patients with chronic renal failure (CRF) undergoing maintenance hemodialysis (HD) and their roles in the pathogenesis of infertility encountered in patients with CRF.
Design: Cross–sectional study.
Setting: Artificial Kidney and Dialysis Unit at Ibn-Sena teaching hospital, Mosul, during the period from July to September 2002.
Subjects: Thirty male patients with CRF undergoing maintenance HD and 30 apparently healthy volunteers (control group) were included in this study.
Method: Complete history and physical examination was performed for every patient included in this study with special emphasis on duration of illness, marital status and fertility. Serum PRL, LH, FSH levels were measured; unpaired t-test was used to assess the difference in the mean of serum level of these hormones between patients with CRF and control group.
Results: Serum PRL, LH and FSH levels were significantly higher (P< 0.0001, P< 0.0001 and P< 0.0001) in patients with CRF in comparison with the control group.
Conclusion: Abnormally high levels of serum PRL, LH and FSH are common in patients with CRF undergoing maintenance HD. This abnormality may play a role in the pathogenesis of infertility in these patients.

Keywords

Pituitary --- gonadal --- hemodialysis


Article
EVALUATION OF SERUM COPPER STATUS IN PATIENTS WITH CHRONIC HEART FAILUR
تقييم مستوى النحاس في مصل مرضى عجز القلب المزمن

Authors: ABDUL-AZIZ A. AZIZ عبدالعزيز عزيز --- SHATHA A. HASSAN شذى حسن --- BAYBEEN K. ALSELEVANY بيبن سليفاني
Journal: Duhok Medical Journal مجلة دهوك الطبية ISSN: ISSN: 20717334 (online)/ ISSN: 20717326 (Print) Year: 2008 Volume: 2 Issue: 1 Pages: 31-40
Publisher: University of Dohuk جامعة دهوك

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Abstract

Background Chronic heart failure is one of the main cardiovascular diseases that has increased prevalence in the recent years and it has been projected that chronic heart failure will be a major cause of morbidity and mortality in the future. Recent researches demonstrate the importance of certain trace elements in the pathogenesis of cardiovascular disorders. Among these elements is copper metal. It is considered as a strong antioxidant. Objectives This study was undertaken in order to investigate the serum copper level in patients with chronic heart failure compared to healthy individuals, and to find whether there is any relationship between serum copper level and patients with chronic heart failure. Patients and methods A case series study was conducted on 53 patients (37 males, 16 females) with chronic heart failure, with a mean age of 52.23+ 13.1 years who randomly selected from patients admitted to medical wards and Cardiac Care Unit of Ibin-Seena Teaching Hospital in Mosul city during the period from July 2006 to December 2006. The study also included 32 healthy volunteers (18 males, 14 females) with a mean age of 41.31+ 14.72 years, as a control group. Serum copper concentration was measured in patients with chronic heart failure and healthy controls. Results The results indicate that patients exhibited significant decrease in the serum copper level (p<0.001) as compared to the healthy controls. Also the results showed that there is no statistically significant difference in the concentration of serum copper between males and females in patients with chronic heart failure (p>0.05). Conclusions and Recommendations Chronic heart failure is a multifactorial syndrome. Several factors had been found to contribute to the development of this syndrome. Low serum copper level may be one of these contributing factors, probably by elevating blood pressure, impairing different tissue formation and inducing high serum cholesterol level. Measurement of serum copper level might provide additional and useful laboratory test for the assessment of the patients with chronic heart failure and oral copper may have a role in therapy.

الخلفية: عجز القلب المزمن يعتبر واحداً من أهم الأمراض القلبية الوعائية والأكثر انتشاراً في السنوات الأخيرة ومن المتوقع أن يكون عجز القلب المزمن السبب الرئيسي لزيادة نسبة الوفيات في المستقبل. البحوث الحديثة وضحت أهمية قسم من المعادن النادرة ودورها في النشوء المرضى للاضطرابات القلبية الوعائية. بين هذه المعادن هو عنصر النحاس الذي يعتبر أقوى مانع للتأكسد .الأهداف: تهدف الدراسة إلى اختبار مستوى النحاس في أمصال المرضى المصابين بعجز القلب المزمن مقارنة مع الأصحاء و لمعرفة فيما إذا كان هناك علاقة بين مستوى النحاس وعجز القلب المزمن.دراسة سلسلة من الحالات.المرضى وطرق البحث: أجريت دراسة سلسلة حالات حيث شملت الدراسة 53 مريضا (37 ذكراو16 أنثى) مصابين بعجز القلب المزمن ، معدل أعمارهم 52.23± 13.1 سنة واللذين تم اختيارهم عشوائيا من المرضى الراقدين في الردهات الباطنية ووحدة العناية القلبية لمستشفى ابن سينا التعليمي في الموصل للفترة من تموز2006 إلى كانون الأول 2006. كما شملت الدراسة 32 شخصا من الأصحاء المتطوعين كمجموعة سيطرة معدل اعمارهم41.31± 14.72 سنة. تم قياس مستوى النحاس في المصل لدى المرضى والمجموعة الضابطة.النتائج: أظهرت نتائج هذا البحث بصورة واضحة نقصا معنويا (احتمالية (0.001> في مستوى النحاس في مرضى عجز القلب المزمن مقارنة مع الأصحاء. كما أظهرت النتائج عدم وجود تأثير معنوي للجنس على تركيز النحاس في مصل المرضى المصابين بعجز القلب المزمن (احتمالية<0.05). الاستنتاج و التوصيات: هناك العديد من العوامل التي تؤدي إلى عجز القلب المزمن وربما يكون انخفاض مستوى النحاس في المصل واحدا من تلك العوامل المساهمة وذلك بارتفاع ضغط الدم , خلل في تكوين أنسجة الجسم المختلفة وتحفيز ارتفاع مستوى الكولسترول في المصل.يجب قياس مستوى النحاس في المصل كفحص اضافى لتقييم المرضى المصابين بعجز القلب المزمن وإعطاء عنصر النحاس عن طريق الفم كعلاج للمرضى المصابين.


Article
The relation of plasma level of atrial and brain natriuretic peptides to left ventricular function in hypertensive patients

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Abstract

Objective: To examine the plasma level of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in patients with hypertension and to evaluate the importance of plasma level of these hormones in predicting the left ventricular function in these patients.
Design: A case-series study.
Setting: Echocardiography Unit of Ibn-Sena teaching hospital and Medical college, Mosul. During the period from August 2004 to March 2005.
Participants: Sixty patients with essential hypertension, were divided into 3 groups depending on severity of the disease. Group I, included 17 patients, group II, included 24 patients and group III, included 19 patients. The study also included 30 apparently healthy volunteers as a control group.
Methods: Plasma ANP, BNP and left ventricular ejection fraction (LVEF%) were measured in hypertensive patients as well as in the control group. The ANOVA test was used to examine the difference in the mean of the studied parameters within patient groups themselves and between patient groups and control. Pearson correlation coefficient was used to study the correlation of the studied parameters within each group. All values are expressed as mean ±SD.
Results: The mean of plasma ANP was significantly higher in group III than that in control group (p<0.001) and group I (p<0.05). The mean of plasma BNP was significantly higher in group III than that in control group (p<0.0001), group I (p<0.0001) and group II (p<0.0001). Furthermore, the plasma BNP was significantly higher (p<0.01) in group II than that in control group. The mean of LVEF% was significantly lower in group III than that in control group (p<0.0001), group I (p<0.0001) and group II (p<0.001). There was a significant negative correlation between plasma BNP level and LVEF% in group III (r = - 0.62, p< 0.005).
Conclusion: The results of this study showed that plasma ANP and BNP levels are significantly increased in patients with severe hypertension. The results also indicate that BNP may be an excellent screening test for left ventricular dysfunction in hypertensive patients.

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