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Article
Seroprevalence of Anti-Rubella IGg Antibody Among Pregnant And Childbearing Women in Diyala Province-Iraq

Author: Abdul-Razak SH. Hasan عبد الرزاق شفيق حسن
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2011 Volume: 1 Issue: 1 Pages: 27-32
Publisher: Diyala University جامعة ديالى

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Abstract

Background: In countries where the rate of susceptible women to rubella infection is higher than 10%, preconceptional or prenatal screening is important to reduce the burden of the disease. Objectives: determination of anti-rubella IgG seropositivity and susceptibility rates among pregnant and childbearing women in Baquba-Diyala province.Subjects and methods: A total of 184 women were enrolled in the present study which was conducted in Baquba-Diyala province during the period from April/2007 to September/2008. Ninety eight pregnant women were chosen from those attending the primary health care centers in Baquba. They include 46(46.9%) who had previous abortions with a mean age 27.2 ± 5.3 years, and 52(53.1%) without previous abortion with mean age 23.7± 5.1 years. Additionally, 86 non-pregnant childbearing women were enrolled as a control group. Of those, 39(45.3%) had previous abortion with mean age 33.5 ± 7.8 years, and 47 (54.6%) without previous abortion, the mean age 30.7±7.8 years. Certain demographic factors were collected by personal interview. Anti-rubella IgG specific antibody were detected by enzyme-linked immunosorbant assay (ELISA). Data were statistically analyzed using SPSS version 13 computer assisted program. P value of < 0.05 was considered significant.Results: The results revealed that the IgG seropositivity among pregnant women without previous abortion, and those with previous abortion was 96.1% and 76% respectively, with a statistically significant difference (p=0.04). The seropositivity among non-pregnant women without previous abortion, and those with previous abortion was 85.1% and 100% respectively, with a statistically insignificant difference (p= 0.11). The overall susceptibility rate for rubella infection was 10.7%. There was insignificant effect of age, educational levels, residency, presence of pregnancy, and history of previous abortion on the seropositivity rate of IgG specific anti- rubella antibody.Conclusion: evaluation of the susceptibility of women in the reproductive age to rubella infection is essential to set a strategy for prevention of congenital rubella syndrome.Keywords: rubella, congenital rubella syndrome, susceptibility rate.


Article
Association of Hepatitis C Virus (HCV) Infection and Human Leukocyte Antigens (HLA)
الترابط بين مستضدات خلايا الدم البيضاء البشرية والإصابة بالتهاب الكبد الفيروسي نمط (C )

Authors: Karim Sadun Ali Al-Ajeeli كريم سعدون العجيلي --- Abdul-Razak SH. Hasan عبد الرزاق شفيق حسن
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2012 Volume: 2 Issue: 1 Pages: 53-59
Publisher: Diyala University جامعة ديالى

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Abstract

Back ground: Several previous reports on the association between hepatitis C virus (HCV) infection and certain human leukocyte antigens (HLA) have yielded controversial results.Objectives: This study was conducted to explore the association of HCV infection and certain HLA in patients from Al-Ramadi Province.Subjects and methods: Thirty two patients with chronic HCV infection as well as 64 apparently healthy individuals and 30 patients with clinically evident acute viral hepatitis, but HCV negative were enrolled in the present study which was conducted in Al-Ramadi city for the period from August/2004 to May/2006. HCV infection was diagnosed by detecting the anti-HCV antibody by enzyme-linked immunosorbant assay (ELISA) and confirmed by Immunoblot assay. Determination of HLAs was done by Microlymphocytotoxicity technique.Results: The results revealed that the presence of HLA-DR5 (Odd ratio 2.7, P 0.022) and HLA-DQ2 (Odd ratio 3.1, P= 0.008), and the absence of HLA-DR7 (Inverse Odd ratio 3.2, P = 0.04) and HLA-DQ1 (Inverse Odd ratio 2.8, P= 0.012) were associated with significantly increased risk for HCV infection as compared to healthy controls. On the other hand, the presence of HLA-DR5 (Odd ratio 6.5, P= 0.005) and HLA-DQ2 (Odd ratio 5.1, P= 0.002), and the absence of HLA-DR7 (Inverse Odd ratio 4.8, P= 0.018) were significantly associated with increased risk for HCV infection.Conclusion: Genetic predisposition may play a role in hepatitis C virus infection in patients from Al-Ramadi city.

تمهيد:الكثير من الدراسات حول العلاقة بين الاصابة بالتهاب الكبد الفيروسي نمط ( C) وبعض مستضدات خلايا الدم البيضاء البشرية اعطت نتائج متباينة. اهداف الدراسة:اجريت هذه الدراسة لاستكشاف العلاقة بين التهاب الكبد الفيروسي نمط (C ) و بعض مستضدات خلايا الدم البيضاء البشرية بين المرضى في مدينة الرمادي.مجاميع الدراسة وطرائق العمل: اثنان وثلاثون مريضا بالتهاب الكبد الفيروسي نمــط (C ) المزمن وكذلك أربعة وستون شخصا من الأصحاء ظاهريا وثلاثون مريضا بالتهاب الكبد الفيروسي من غير فيروس التهاب الكبد نمط (C ) قد تم شمولهم بهذه الدراسة التي أجريت في مدينة الرمادي للفترة آب 2004 إلى مايس 2006 . تم تشخيص التهاب الكبد الفيروسي نمط (C) بالكشف عن الضدات النوعية للفيروس بتقنية الاليزا والفحص ألتوكيدي بتقنية التراص الناعي . تحديد مستضدات خلايا الدم البيضاء البشرية اجري بتقنية Microlymphocytotoxicity . النتائج:أظهرت النتائج أن وجود المستضد HLA-DR5 (Odd ratio 2.2, P=0.022 ) المستضد HLA-DQ2 (Odd ratio 3.1, P=0.008 ) وعدم وجــود المستضدHLA-DR7 ( Inverse odd ratio 3.2, P= 0.04) والمستضد HLA-DQ1 (Inverse odd ratio 2.8, P= 0.012 ) مترابط مع زيادة معنوية في معدل الخطورة للإصابة بالتهاب الكبد الفيروسي نمط (C ) مقارنة بمجموعة السيطرة للأشخاص الأصحاء. من جانب آخر، فان وجود المستضد HLA-DR5 (Odd ratio 6.5, P= 0.005 ) و المستضد HLA-DQ2 ( Odd ratio 5.1, P=0.002 ) وعدم وجود المستضد HLA-DR7 (Inverse odd ratio 4.8, P= 0.018 ) مترابط مع زيادة معنوية في معدل الخطورة للإصابة بالتهاب الكبد الفيروسي نمط (C ) مقارنة بمجموعة السيطرة للمرضى. الاستنتاج: العوامل الوراثية يمكن أن تلعب دورا في الإصابة بالتهاب الكبد الفيروسي نمط (C ) في مدينة الرمادي.


Article
Virulence Factors of Proteus Mirabilis Isolated From PatientsOtitis Media in Baquba And it’s Peripheries

Authors: Abdul-Razak SH. Hasan عبد الرزاق شفيق حسن --- Nadhum G. Nauman عباس الدليمي --- Abbas A. Al-Duliami عباس الدليمي
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2011 Volume: 1 Issue: 1 Pages: 69-75
Publisher: Diyala University جامعة ديالى

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Abstract

The objective of this study is to evaluate the impact of prostate-specific antigen density ( PSDA ) when serum levels of prostate-specific antigen ( PSA ) are less than 10 ngml in predicting prostate cancer. We retrospectively analyzed 134 patients who underwent trans rectal ultrasound ( TRUS )-guided prostate biopsies according to Cooner's algorithm. Histopathological examination revealed prostate cancer ( PCa ) in 22 ( 16% ) and begin prostatic hypertrophy ( BPH ) in 112 ( 84% ) patients.Five patients ( 23% ) with PCa had PSAD<0.15 of whom 3 had PSA<4 ngml and 2 had PSA between 4 and 10 ngml. In the BPH group, 60 patients ( 54% ) had PSAD below 0.15 whereas 52 patients ( 46% ) had PSAD over 0.15 . with 0.15 as the cutoff level of PSAD, the sensitivity and specificity of PSAD was found as 77 and 54%, respectively. In this patient population, PSA with the cutoff level of 4 ngml has sensitivity and specificity level of 77 and 33% respectively. According to these result, a statistically significant difference was found between PSA and PSAD only in terms of diagnostic specificity ( chi-square, P<0.05 ) . There were 29 patients with negative digital rectal examination ( DRE ) and TRUS and PSA 4-10 ngml who underwent biopsy because of PSAD>0.15 . no cancer was detected in this group of patients, suggesting that biopsy in this subgroup may be unnecessary.


Article
Antimicrobial Susceptibility Patterns of Enterococcal Isolates And its Relevance With Biofilms Formation And &#914; -Lactamase Production

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Abstract

Background: Enteroccci are part of the normal intestinal flora of human and animal, but with increasing antimicrobial resistance, enterococci are recognized as serious nosocomial as well as community pathogens. Objectives: To investigate the antimicrobial susceptibility patterns of 44 isolates of enterococci recovered from different pathological specimens from in-and out-patients from Diyala province.Materials and methods: The present study was conducted in Baquba General Hospital and Al-Batool Hospital for Maternity and children during the period from 1st. September/2005 to 30th. September /2006. A total of 343 specimens were collected from 213 inpatients and 130 outpatients. 200 (58.3%) were females and 143 (41.7%) were males. The mean age of patients was (32.8 ± 17.2) years. Specimens include, urine, stool, vaginal swabs, throat swabs, burn swabs, blood for culture, middle ear swabs, wound swabs, sputum and cerebrospinal fluid. Specimens were streaked on blood agar, and other differential and selective media. 44 isolates of enterococci (30 E. faecalis, 10 E. faecium, 3 E. gallinarium, and 1 E. avium) were recovered and identified according to standard bacteriological and biochemical criteria. The susceptibility patterns toward 13 antimicrobial agents were done by disc diffusion method. Data were statistically analysed. Results: The results revealed that the highest susceptibility of enterococcal isolates was toward the Nalidixic acid (79.5%), Ciprofloxacin (61.4%), Amoxacillin+clavilanic acid (61.4%), Rifampicillin (36.4%),Trimethoprim (22.7%), Vancomycin (11.4%). However, all isolates were resistant to Cloxacillin, Cefotaxim, Amoxicillin, Tetracycline, and Erythromycin. The susceptibility of non- β -lactamase producing isolates to penicillin were significantly higher than β - lactamase producing isolates (p<0.001). Furthermore, the sensitivity of non-biofilms former isolates were significantly higher than that of biofilms former isolates (p= 0.002).Conclusion: The overall susceptibility rates of enterococcal isolates recovered from nosocomial as well as community acquired infections to available antimicrobials are low.


Article
Is There Any Relationship Between Hepatitis C Virus Infection and Skin Diseases ?
هل هناك علاقة بين الاصابة بفيروس التهاب الكبد نمط (ج) والامراض الجادية ؟

Authors: Abbas A. Al-Duliami عباس الدليمي --- Khudiar Kh. Al-Kiali خضير خلف الكيالي --- Abdul-Razak Sh. Hasan عبد الرزاق شفيق حسن
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2012 Volume: 3 Issue: 1 Pages: 51-56
Publisher: Diyala University جامعة ديالى

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Abstract

Background: Hepatitis C virus (HCV) has been associated with several extrahepatic conditions. Although a high prevalence of HCV infection was detected in patients with lichen planus, the pathogenetic potentials of HCV with skin diseases is still controversial.Objectives: To determine the anti-HCV antibody seropositivity among patients with certain non-communicable skin diseases; lichen planus, psoriasis, alopecia areata, vitiligo, eczema, and urticaria.Patients and methods: Two hundred patients suffering from non-communicable skin disease were enrolled in this study which was conducted in Baquba for the period from 1st. November/2010 to 1st. July/2011. The patients were attending the Dermatology and Venereology Unit in the outpatient clinic of Baquba General Teaching Hospital. The patients group consists of 18 patients with lichen planus, 23 with psoriasis, 7 with vitiligo, 95 with eczema, 36 with chronic urticaria, and 21 with alopecia areata. The age range of the patients was (5-70) years. Additionally, 90 apparently healthy unpaid blood donors were included as control group. Anti-HCV antibody was detected by enzyme linked immunosorbant assay. Rsults: Only two patients were positive for anti-HCV antibody; one with lichen planus and another with eczema. All other patients with psoriasis, alopecia areata, vitiligo, and urticaria were negative for anti-HCV antibody. There was no significant association between HCV infection and skin diseases under study.Conclusion: No association between HCV infection and lichen planus, psoriasis, alopecia areata, vitiligo, eczema, and urticaria, probably due to low prevalence of HCV infection among general Iraqi people.Key words: HCV infection, lichen planus, psoriasis, alopecia areata, vitiligo.

تمهيد: تمتاز الاصابة بفيروس التهاب الكبد نمط (ج) بارتباطها بالعديد من الحالات المرضية خارج الكبد0 بالرغم من سعة انتشار الاصابة بفيروس التهاب الكبد نمط (ج) بين مرضى الحزاز المسطح، فان الدور المرضي المحتمل للفيروس في الامراض الجلدية لاتزال مثيرة للجدل0اهداف الدراسة:تهدف الدراسة الى تحديد نسب الاصابة بفيروس التهاب الكبد نمط (ج) بين المرضى المصابين ببعض الامراض الجلدية غير الانتقالية وهي ، الحزاز المسطح ، داء الصدفية ، داء الثعلبة ، البهاق ، الاكزيما و الشرى0المرضى وطرائق العمل: أجريت هذه الدراسة في مدينة بعقوبة للفترة من الاول من تشرين الثاني 2010 ولغلية الاول من تموز 2011 ، وشملت 200 مريض ممن يعانون من الامراض الجلدية غير الانتقالية من المرجعين لوحدة الامراض الجلدية والزهرية في العيادة الخارجية امستشفى بعقوبة التعليمي0 وتكونت مجموعة المرضى من 18 مريضا مصابون بالحزاز المسطح ، 23 مريضا مصابون بداء الصدفية ، 7 مرضى مصابون بالبهاق ، 95 مريضا مصابون بالاكزيما ، 36 مريضا مصابون بالشرى المزمن و 21 مريضا مصابون بداء الثعلبة0 معدل اعمار المرضى تراوحت بين 5-70 سنة0 فضلا عن ذلك فقد شملت الدراسة على 90 شخصا من الاصحاء ظاهريا كمجموعة سيطرة تم جمعهم من متبرعي الدم0 تم الكشف عن الضدات النوعية لفيروس التهاب الكبد نمط (ج) بتقنية الاليزا في وحدة الفيروسات في مختبر الصحة العامة في بعقوبة0النتائج: اظهرت الدراسة بان اثنين فقط من المرضى كانوا مصابين بفيروس التهاب الكبد نمط (ج)، احدهما مصاب بالحزاز المسطح والاخر مصاب بالاكزيما، اما بقية المرضى المصابون بداء الصدفية ، داء الثعلبة ، البهاق و الشرى فقد كانت نتائجهم سلبية0 لم تكن هنالك علاقة معنوية بين الاصابة بفيروس التهاب الكبد نمط (ج) والامراض الجلدية موضوع الدراسة0الاستنتاج: لم يكن هنالك ترايط بين الاصابة بفيروس التهاب الكبد نمط (ج) والاصابة بالامراض الجلدية كالحزاز المسطح، داء الصدفية ، داء الثعلبة ، البهاق ، الاكزيما و الشرى ، ربما بسبب تدني نسب الاصابة بهذا الفيروس بشكل عام بين العراقيين0الكلمات المفتاحية: فيروس التهاب الكبد نمط (ج)، الحزاز المسطح، داء الصدفية، داء الثعلبة، البهاق.

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