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Relation between thyroid disorders and polycystic ovary syndrome
العلاقه بين اضطرابات الغدة الدرقيه ومتلازمة تكيس المبايض

Authors: Abdulrazak H. Alnakash عبد الرزاق النقاش --- Suhayla Abass سهيلة عباس --- Sahar Jassim Abid سحر جاسم
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2017 Volume: 30 Issue: 2 Pages: 68-75
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Abstact:Background: Polycystic ovarian syndrome which is the most common endocrinopathy of women at their reproductive age seems to be associated with thyroid dysfunction, but it’s true patho¬genesis is far from being elucidated. Both have independent risks of ovarian dysfunction and pregnancy related complications.Objective: To evaluate the association between thyroid dysfunction and polycystic ovary syndrome (PCOS).Study Design: Prospective Case-Control Study.Setting: Department of Obstetrics and Gynecology/ AL-Elwiya Maternity Teaching Hospital, Baghdad - IraqPatients and Methods: The study included 100 women at reproductive age, 50 of them were defined as having polycystic ovary syndrome (study group), another 50 healthy women served as control group. Thyroid function and morphology were evaluated by measuring serum thyroid stimulating hormone (TSH), free thyroxine levels (free T3 and free T4), anti thyroperoxidase antibody (anti TPO Antibody) and anti-thyroglubulin antibody (anti-TG Antibody) and by clinical and ultrasound examination of thyroid gland. Results: The study revealed statistically higher prevalence of autoimmune thyroiditis in patients with PCOS (12% vs. 4% of control) as evidenced by raised anti-TPO antibody levels (means125.91±333.39 and 88.19±316.18 respectively; P =0.563). PCOS patients were found to have higher mean TSH level than that of the control group (3.14±2.74and 2.24±1.81respectively; P value < 0.05). There was high prevalence of goiter among PCOS patients (10.0%vs. 4% of control, P value > 0.001). On thyroid ultrasound, a significantly higher percentage of PCOS patients (10%; controls 2.5%) had hypoechoic ultrasound pattern which also compatible with diagnosis of autoimmune thyroiditis.Conclusions: Higher prevalence of thyroid disorders in the form of autoimmune thyroiditis in patients suffering from PCOS (12%) compared with control group (4%).


Article
A STUDY OF SERUM MAGNESIUM AND CALCIUM LEVELS IN MISSED ABORTION

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Abstract

Background:Pregnancy is considered as a physiological stress, normal static metabolism of a woman is changed into dynamic anabolism, calcium (Ca) is the first most abundant cation in the human body, whereas magnesium (Mg) is the fourth most abundant one, role of calcium and magnesium in enzymatic activity of cell to release energy is well established.Objective:To assess the relation of serum magnesium and calcium levels in cases of missed abortion.Methods:Eighty two pregnant women at their 1st and 2nd trimester of pregnancy (before 24 completed weeks of pregnancy), 42 of them with missed abortion compared with 40 normal pregnancies served as a control group. Calcium analysis done using manual colorimetric method while magnesium analysis was done by magnesium calmogite method at the hospital laboratories.Results:Serum calcium was found to be insignificantly altered while serum magnesium was found to be significantly reduced in cases of missed abortion compared with normal pregnancy. Serum Ca/Mg ratio was found to be significantly elevated in cases of missed abortion compared with normal controls.Conclusion:Estimation of serum magnesium and Ca/Mg ratio in selected pregnancies can be valuable parameters for predicting missed abortion.Keywords:Missed abortion, Serum Calcium, Serum Magnesium.

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