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Article
Hormonal Contents of Two Types of Black Seed (Nigella sativa) Oil: Comparative Study

Authors: Abdulsamie H. Alta'ee عبدالسميع حسن الطائي --- Mufeed J. Ewadh مفيد جليل عوض --- Haider K. Zaidan حيدر كامل زيدان
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2006 Volume: 3 Issue: 1-2 Pages: 17-21
Publisher: Babylon University جامعة بابل

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Abstract

The use of black seed (Nigella sativa) capsules as a herbal therapy to lower blood glucose in diabetic patients are associated with menstrual cycle irregularities. The present study was designed to analyses and to compare between two types of Nigella sativa (N.sativa) agricultures in Mosul region and those imports from Saudi Arabia Kingdom, and to investigate the levels of hormones in volatile oil of black seed that regulate menstrual cycle that might be present in Nigella sativa. Volatile oil of N.sativa was extracted by steam distillation using diethyl ether as an organic solvent.Then, hormones analysis were done using (miniVIDAS software version) instrument. Results of present study showed a presence of considerable amount of sex hormones estradiol, progesterone, prolactin, testosterone, FSH and LH .This might interpret the cause of menstrual cycle irregularities occur when black seed capsule was taken as a herbal therapy to lower blood glucose in diabetic patients.

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Article
The Correlation between Lipid Profile and Lipid Peroxidation in Patients with Acute Myocardial Infraction

Authors: Mufeed J. Ewadh مفيد جليل عوض --- Abdulsamie H. Alta'ee عبدالسميع حسن الطائي --- Husain S. Aljanabi --- Alaa Hummady Alta’ee
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2005 Volume: 2 Issue: 3 Pages: 301-306
Publisher: Babylon University جامعة بابل

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Abstract

To measure the association between risk factor of cardiovascular disease (CVD) and lipid peroxidation in patients with acute myocardial infraction (AMI) and healthy controls, twenty six patients (17 males, 9 females) with AMI clinically diagnosed admitted to Merjan Teaching Hospital in Hilla city and fifty two (25 males ,27 females) apparently healthy persons as a controls subject to present study. Determination of serum total cholesterol (TC), triacylglycerol (TG), high density lipoprotein (HDL)-cholesterol, serum glutathione and serum lipid peroxidation were preformed using colorimetric methods. Very low density lipoprotein (VLDL) and low density lipoprotein (LDL) was determined using mathematically method. TC and TG of males with AMI found to be significantly increased and total cholesterol of females with AMI found to be increased when compared with healthy controls. HDL- cholesterol of patients found to be decreased, whereas risk factor was significantly increased. VLDL of patients with AMI found to be significantly decreased, whereas LDL found to be significantly increased. Lipid peroxidation was increased, but serum glutathione was declined significantly in patients with AMI when compared with healthy controls. The correlation between lipid peroxide and TG shows a positive relationship of oxidation product excretion at higher levels of TG. We conclude that patients with elevated levels of serum TG and cholesterol are at increased risk of oxidative damage due to lipid peroxidation.

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Article
High Risk Factor Values of Cardiovascular Disease and Uric Acid Levels in Sera of Patients with Type 1 Diabetes Mellitus

Authors: Asim A.Alsalihy --- Khowla A. Shemran --- Abdulsamie H. Alta’ee عبدالسميع حسن الطائي --- Mufeed J. Ewadh --- et al.
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2004 Volume: 1 Issue: 3-4 Pages: 225-233
Publisher: Babylon University جامعة بابل

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Abstract

Diabetes mellitus is a chronic illness required ongoing medical care. As a result, laboratory testing has become an essential part of the evaluation and monitoring process in diabetes management. Further tests are required to establish the correlation between hyperglycemia and other disease parameter. Therefore, the correlation between cardiovascular disease risk factor values and uric acid levels in sera of adult patients with type 1 diabetes mellitus (without renal diseases) and healthy controls have been studied. Total cholesterol, HDL-cholesterol and uric acid in sera of 52 patients (36 males and 16 females) with poor hyperglycemic control type 1 diabetes mellitus and 30 healthy controls (19 males and 11 females) were determined. Results of present study show significantly higher risk factor values (P < 0.001), which means increasing in the probability of atherosclerosis incidence. Also hyperglycemia found to be associated with hyperuricemia in type 1 diabetic patients.

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Article
Cytidine Deaminase Activity In Breast Cancer
فعالية السايتدين دي امينيز في سرطان الثدي

Authors: Oda M. Y. Al-Zamely --- Mufeed J Ewadh مفيد جليل عوض --- Abdulsamie H. Alta'ee عبدالسميع حسن الطائي
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2004 Volume: 1 Issue: 1 Pages: 32-39
Publisher: Babylon University جامعة بابل

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Abstract

Cytidine deaminase (CTD) catalyzed the deamination of cytidine (CR) to uridine (UR) is a cytoplasmic enzyme existing in many kind of cells and widely distributed among mammalian tissues. It has beel1 reported to be a sensitive indicator in several types of abnormalities. CTD activities in sera of thirty-eight females with breast cancer (BC) and twenty-five healthy females asa contrcl were measued using a spectrophotometric method. Also electophoretic patte.n ofsera of patients with BC and healthy fernales were assayed using polyacrylamide gel electrophoresis(PAGE) to differentiate between normal and abnomal proteins existing in the two cases.Compared with healthy females, CDA activities found to significantly increase in sera of patients with BC (4.96+ 2.34, 13.3 + 3.72 U/L) (P < 0.000) respectively. PAGE profile of sera of patients with BC shows wide variety than that of nomal females.These results may consider a novel biochemical marker to aid in the diagnosis of BC.

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Article
The Chemotherapy Drugs Correlation With Red Blood Cells Antioxidants And Plasma Uric Acid

Authors: ASIM A.ALSALEH --- Mufeed J. Ewadh --- KHOWLA A. SHEMRAN --- MOHAMMED R.JODI --- et al.
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2004 Volume: 1 Issue: 1 Pages: 56-61
Publisher: Babylon University جامعة بابل

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Abstract

The effect of specified drugs on The red blood cells glutathione level have been studied and the result revealed that mitomycine-c has a large effect at the concentration of 0.6 mg /ml which indicate the distraction of cell memdrane and there is no transport systbm for such drugs. This novel study revealed that we have give an attention to the dose given to the patients

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Article
Serum Testosterone and Prolactin in Posttraumatic Stress Disorder for Iraqi Terror Attack Victims
تيستوستيرون وبرولاكتين المصل في مرضى اضطراب ما بعد الصدمة لضحايا العمليات الارهابية في العراق

Authors: Tarik Hufdy Al-Khayat --- Waleed Azeez Al-Ameedy --- Lamia Abdul Majeed --- Abdulsamie H. Alta'ee عبدالسميع حسن الطائي
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2013 Volume: 10 Issue: 2 Pages: 310-319
Publisher: Babylon University جامعة بابل

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Abstract

Background: Abnormal levels of testosterone and prolactin have been reported in various psychiatric disorders and the important roles of in the regulation of many processes in human metabolism have been described.Objective: Investigate the hormonal changes in posttraumatic stress disorder (PTSD) patients and control group.Patients and Methods: Eighty two males witnessed on explosion occurred at 10th June 2010 in Hilla city of Iraq, as well as thirty five males apparently healthy persons as a control groups. Participants were grouped to four groups according to PTSD Checklist (PCL) scores. Total testosterone, free testosterone, and prolactin (PRL) were determined using ELISA. Results: Total testosterone, free testosterone, and PRL showed an insignificant decreased in all groups of PTSD patients, when compared to control group. There is negative correlation between each of total testosterone, free testosterone, and PRL with severity of PTSD.Conclusion: Results of present study may indicate that there are inhibition of hypothalamic-pituitary-gonadal (HPG) and hypothalamic-pituitary-prolactin (HPP) axes in PTSD patients.

الخلفية: لوحظ في العديد من الامراض النفسية مستويات غير سوية لكل من هرموني التيستوستيرون والبرولاكتين ولهما دورا مهما في تنظيم العديد من العمليات الايضية في جسم الانسان.الاهداف: التقصي عن التغيرات الهرمونية في مرضى اضطراب مابعد الصدمة.المرضى والطرق: شملت الدراسة اثنان وثمانون رجلا ممن شهدوا الانفجار الحاصل في العاشر من حزيران 2010 في مدينة الحلة- العراق وخمسة وثلاثون رجلا سليما ظاهريا كمجموعة سيطرة. قسم المشاركون الى اربعة مجموعات طبقا لدرجات لائحة اضطراب مابعد الصدمة . قدر التيستوستيرون الكلي والحر والبرولاكتين بتقنية الالايزا.النتائج: اظهرت النتائج انخفاضا غير معنويا في مستويات كل من التيستوستيرون الكلي والحر والبرولاكتين عند مقارنتها مع تلك النتائج المستحصلة لمجموعة السيطرة. ولوحظت علاقة سالبة بين كل من مستويات التيستوستيرون الكلي والحر والبرولاكتين شدة المرض.الاستنتاج: تدل نتائج الدراسة على تثبيط كل من المحورين الهرمونيين HPG و HPP عند المرضى باضطراب ما بعد الصدمة.


Article
The Behavior of the Plasma Homocysteine and Selenium Concentrations in Patients with Acute Myocardial Infarction
سلوك مستويات الهوموسيستين والسيلينيوم في بلازما دم المصابين باحتشاء العضلة القلبية الحاد

Authors: H. Renz --- S. Mkhlof --- Aamir S. AL-Mu'min --- Abdulsamie H. Alta'ee عبدالسميع حسن الطائي --- et al.
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2008 Volume: 5 Issue: 3-4 Pages: 543-550
Publisher: Babylon University جامعة بابل

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Abstract

Background: Increased concentrations of plasma total homocysteine and decreased concentrations of plasma selenium are separately associated with cardiovascular disease. Objective: Investigate the correlation between plasma total homocysteine and selenium in patients with acute myocardial infarction (AMI). Methods: Patients of present study was thirty nine men with AMI admitted to Marburg Hospital in Marburg city, Germany on 2007. Plasma total homocysteine was determined using HPLC. Plasma selenium was determined using atomic absorption spectrometry. Results: Plasma homocysteine of patients found to be increased, whereas plasma selenium found to be decreased when compared with reference range . The correlation between plasma homocysteine and selenium found to be negatively correlated. Conclusion: The negative correlation between plasma tHcy and selenium may indicate that they have a significant impact on the process of atherogenesis. The change in the levels of plasma total homocysteine and plasma selenium might be result from oxidative stress associated with AMI.

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Article
Epidemiological Study of Lipid Profile in Aldiwaniya Governorate

Authors: Amjed H.Salman --- Khowla A.Shemra --- Asim A.Alsalihy --- Hussien S. Al-Janabi --- et al.
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2004 Volume: 1 Issue: 2 Pages: 128-136
Publisher: Babylon University جامعة بابل

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Abstract

During the past decade, numerous experimental and clinical srudies have demonstratecl that many common conditions predisposing to cardiovascular disease, such as hypercholesterolemia,hypertension, diabetes, and smoking. Thus a population-based study in Aldewaniya city was conducted in sera of432 people (201 males,231 fenales) randomly chosen to define the Drevalence of va oustype of hypertipidaemia and to establish the reference ranges of serum toiat chotesterol (TC),triglycerides (TG), low-densiq, lipopotein (LDL) cholesrerol, very low-densiry lipoprorein (VLDL)cholesterol, and high-density lipoprotein (HDL) choleslercl. peopte subjects to present study wereclassified into seven age goups e20-<70 years). The prevalenco of hperlipidaemia was higher infemaies than mal€s. TC, TG, LDl-cholesrerol. and VlDLcholesterol found to be associated withprogressive of age. IlDl-cholesterol found to be depleted with Fogressive of age

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Article
The Association between Thyroid Hormones and Lipid Profile in Patients with Primary Hyperthyroidism
الترابط بين هرمونات الغدة الدرقية ومعالم الدهون في مرضى فرط الغدة الدرقية الابتدائي

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Abstract

AbstractBackground: Thyroid hormones are important at cellular level, affecting nearly every type of tissue in the body.Objectives: The present study was carried out to deter¬mine whether thyroid hormones affect lipid profile in patients with hyperthyroidism.Materials and Methods: This study was carried out on 22 hyperthyroid patients (11 men and 11 women), with mean age 48.5±13.1 years and 24 apparently healthy control (12 men and 12 wome), with mean age 49.5±11.4 years). Serum levels of, thyroid stimulated hormone TSH, thyroxine (T4) and triiodothyro¬nine (T3) were measured by ELISA technique, and total cholesterol (TC), high-density lipo-protein cholesterol (HDL-C), and Triglyceride (TG) were measured spectrophotometrically, while low-density lipoprotein cho¬lesterol (LDL-C) and very low-density lipoprotein cho¬lesterol (VLDL-C ) were calculated.Results: Thyroid stimulated hormone TSH, lipids and lipoproteins (TC, TG, HDL-C, LDL-C, VLDL-C ) levels of patients were significantly lower than those of the control group ( p> 0.05). And there were significant increases in serum thyroid hormones T4, T3 values (p > 0.05). Conclusion: Hyperthyroidism is associated with decrease levels of lipoprotein, caused by increased hepatic uptake due to an enhanced affinity for the LDL receptor, and regulatory protein of TG (ApoAV).

الخلاصةالخلفية:هرمونات الغدة الدرقية مهمة على المستوى الخلوي وتؤثر تقريبا على كل أنواع الأنسجة في الجسم.الأهداف: أجريت الدراسة الحالية لتبيان فيما اذا كان هناك تأثير لهرمونات الدرقية على مستويات الدهون في المرضى المصابين بفرط الغدة الدرقية.المواد والطرق:أجريت الدراسةِ على 22 مريضا مصابا بفرطِ الغدة الدرقية (11 رجل و11 امراه ، بمتوسطِ عمر 48.5 ±13.1 سنة) و 24 شخص سليم ظاهريا (12 رجل و12 امرأة) بمتوسطِ عمر 49.5 ±11.4 سنة). تم تقدير مستويات هرمون TSH , الثايروكسين ( (T 4, الثريونين ثلاثي اليود (T 3) بتقنية الالايزا ،والكولسترول الكليّ (TC)، وكولسترول البروتين ألدهني عالي الكثافةِ (HDL- C)، والكلسيرات الثلاثية (TG) بطرق طيفية بينما تم حساب كولسترول البروتين ألدهني واطئ الكثافة (LDL- C) وكولسترول البروتين ألدهني منخفضِ الكثافةِ جدا (VLDL-C) بطرق حسابية.النَتائِج : وجد إن مستويات هرمون TSH والكولسترول الكلي ( (TC والكلسيرات الثلاثية (TG) وكولسترول كل من البروتين ألدهني عالي و واطئ ومنخفض الكثافة جدا HDL-C)، C-LDL، VLDL-C ) كانت واطئة جدا وبشكل معنوي مقارنة بمجموعة السيطرة كما لوحظ زيادة معنوية(P <0.05) في مستويات هرمونات الدرقية (T3)و (T4).الاستنتاج :يرتبط فرط الغدة الدرقية مع النقصان في مستويات البروتينات الدهنية ، بسبب زيادة أخذها من قبل الكبد والذي يعزى إلى زيادة الألفة لمستقبلات (LDL-C) والبروتين المنظم للكلسيرات الثلاثية (TG) المسمى Apo AV.


Article
Diabetes Mellitus Correlation with Free Radicals and Creatine Kinase Isoenzymes Activity

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Abstract

To explain the relationship between free radicals production in experimentally diabetic animals and expected glutathione (GSH) reducing levels with its enhancement due to feeding of cysteine, N-acetyl cysteine and to evaluate the action of antioxidant to relief the damage to the active site of creatine kinase (CK) caused by free radicals, three doses during 48 hours of 150 mg alloxan / kg body weight was injected to forty eight males albino mice to produce the diabetes mellitus. Blood glucose and serum glutathione were determined using colorimetric methods, whereas, fractionation of CK isoenzymes in sera of diabetic mice was conducted by mini column ion exchange chromatography using Sephadex A-50. Agarose gel electrophoresis was used to quantitize the CK isoenzymes. Results of present study show that after long period of induced diabets in males albino mice cause a change in CK isoenzyme distribution pattern The total serum CK activity decreased in 75% of animals and reached to 63.5% of the control value whereas CK - MM isoenzyme was also decreased to 54.1% of its initial activity. Other isoenzymes showed variation depending upon the period of diabetes induced which caused elevated levels after 30 days of CK -BB isoenzyme in 62.5% of the animal studied and reached to 68% more than its initial activity which in < 3%. CK - MB which is found in 25% of albino mice was elevated to 17.1% more than that found in control sera which is < 3%. Insulin affects total CK activity and its isoenzymes distribution pattern as a therapeutic agent, and CK activity found to be elevated Thiol containing compounds including cysteine, N-acetyl cysteine dithiothreitol and glutathione have been suggested to reactivate the CK activity.

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