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Comparative study of the renoprotective effects of captopril and aminophylline against cainst cisplatin – induced nephrotoxicty in rats

Author: Adel .H .Sheeh عادل شيح
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2010 Volume: 6 Issue: 1 Pages: 28-32
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Cisplatin is one of the most commonly used anti-cancer drugs , but its clinical use was limited by its nephrotoxicity .Methods: In this study we try to investigate the renoprotective effect of captopril and aminophylline against cisplatin induced nephrotoxicity .For this purpose a 36 Sprague Dawley rats was divided randomly to 6 groups , each group consist of 6 rats. The first group given normal saline and act as control group, while the other 5 groups given cisplatin ( 7.5 mg/kg ) , captopril ( 60 mg/kg ) , aminophylline ( 24 mg/kg ) , captopril with cisplatin and aminophylline with cisplatin respectively. All drugs are given as single dose through intraperitonial route. After 6 days blood urea and serum creatinine, malondialdehyde and glutathione are measured and compared with control group.Results: The data show that both captopril and aminophylline posses renoprotective effect against cisplatin – induced nephrotoxicity, also the data show that captopril renoprotective effect is more than that produced by aminophylline.Conclusions: This data can help in increase the dose of cisplatin in clinical uses together with use of renoprotective agent , specially if the patient already need such renoprotective drugs for treatment of disease a way from cisplatin as hypertension .Also more clinical studies required for more assessment of the clinical pattern of this renoprotective effect


Article
Re-evaluation of lunation of the activity of somantibacterial drugs against clinical isolates of Escherichia coli in al- najaf al- ashref governorate

Authors: Adel H. Sheeh عادل شيح --- Saad B. Nashtar سعد نشتار
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2010 Volume: 6 Issue: 1 Pages: 21-27
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Escherichia coli is one of the most important bacterial pathogen that can cause several disease to human being . In our study we try to investigate the sensitivity resistance pattern of Escherichia coli against three antibiotics ( Amikacin, Nalidixic acid and Cephalexin). Methods: For this purpose we collected 51 clinical isolates of Escherichia coli from stool and urine of outpatient and inpatient patients from different wards of AL-SADER Teaching Hospital in AL-NAJAF AL-ASHRAf, IRAQ, and tested by culture and sensitivity test . Results: The results appeared that Amikacin show the highest percentage of sensitivity ( 66.66 % ) , while Cephalexin show the lowest percentage of sensitivity ( 6.34 % ) .Conclusions: we conclude that Amikacin is the most sensitive antibacterial drug for Escherichia Coli as compared with Nalidixic acid and Cephalexin, while Cephalexin is the most resistant antibacterial drug for Escherichia Coli as compared with Amikacin and Nalidixic acid.

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