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Article
Synthesis, X-Ray Crystal Structure, Bactericidal and Kinetic Study of some Mononuclear Zinc and Mercury Complexes Supported by Bisaroylhydrazone Derivatives

Authors: Ahmed Jasim M Al-Karawi --- Refaa Burhan Kazem
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2019 Volume: 22 Issue: 1 Pages: 15-24
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

This work includes the synthesis of two derivatives of cyclohexane bisaroylhydrazone: (L1) and (L2). These compounds were synthesized via the condensation reaction of 1,2-cyclohexanedione with an appropriate hydrazide derivative in acidic medium. The prepared ligands were reacted with zinc chloride or mercury chloride under ambient conditions. Consequently, mononuclear type complexes: [Zn(L1)Cl2] (1), [Zn(L2)Cl2].CH3CN (2). [Hg(L1)Cl2] (3) and [Hg(L2)Cl2].CH3CN (4) were obtained. Different techniques have been used to characterize the prepared organic ligands and their metal complexes (X-ray single crystal crystallography and microelemental analyses in addition to infrared, nuclear magnetic resonance, X-ray powder diffraction, Ultraviolate-visible-Near infrared, and mass spectroscopes). Depending upon the X-ray crystallography, it seems that the obtained products of 1, 2, 3 and 4 are mononuclear complexes. Each structure comprises a [M (L)]2+ core. The kinetic of complex formation of 2 was investigated and the results are investigated and compare with that of 4. The study showed in general, the formation of 2 and 4 in one phase with a first-order type reaction. Antibacterial activities of all the prepared compounds against some pathogenic bacteria (Staphylococcus aureus and Escherichia coli) were evaluated, which exhibit a good growth inhibitory activity.


Article
Synthesis of New Type of Sugar Ligands Starting from D-Glucose And Screening Their Biological Activity

Authors: Adnan I. Mohamad Al-saadi --- Ahmed Jasim M. Al-karawi --- Dhafir T.Ajeel Al-heetimi --- Faleah Hassan Ali
Journal: journal of kerbala university مجلة جامعة كربلاء ISSN: 18130410 Year: 2010 Volume: 8 Issue: 4 Pages: 53-60
Publisher: Kerbala University جامعة كربلاء

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Abstract

This work includes two parts; the first one is the synthesis of two ligands starting from D-glucose, reaction of glucose with acetone in the presence of iodine afforded 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose(1), when (1) reacted with benzoyl chloride in pyridine gave 1,2:5,6-di-O-isopropylidene-3-O-(benzoyl)-α-D-glucofuranose (2), selective deprotection of (2) in 80% acetic acid yielded 1,2-O-isopropylidene-3-O-(benzoyl)--α-D-glucofuranose (3), the cleavage oxidation of (3) using sodium periodate gave the aldehyde (4), the reaction of (4) with 4-methylthiosemicarbazide and o-aminophenol afforded the sugar ligands (5) and (6) respectively.The second part of this work contained the biological screening of the prepared sugar ligands against Gram + ve bacteria Staphylococcus Aureus (ATCC 25923), Gram – ve bacteria Escherischia Coli (ATCC 225922), Pseudomonas Aaruginosa (ATCC 27853), and against fungi Candida Albicans (ATCC 10231), this part of our study showed that only compound (5) exhibited activities against + ve bacteria Staphylococcus Aureus and Gram – ve bacteria Escherischia Coli at concentration of 5 ppm.

يتضمن العمل الحالي قسمين أساسيين: القسم الأول تحضير المخلبيات السكرية أبتداء ً من سكر د-كلوكوز وكما يلي: تم مفاعلة سكر د-كلوكوز مع الأسيتون وبوجود اليود كعامل مساعد واعطت هذه العملية المركب(1), عومل المركب (1) مع كلوريد البنزويل بوجود البريدين لينتج المركب (2), أزالة الحماية الأنتقائية للمركب (2) بواسطة استخدام 80% حامض الخليك أعطت المركب (3), تفاعل الأكسدة-أنشطار للمركب (3) باستخدام بيرأيودات الصوديوم أنتج الألديهايد (4), مفاعلة الألديهايد (4) مع 4-مثيل ثايوسيميكاربازايد و أوروثو-أمينوفينول انتجت المخلبيات السكرية (5) و (6) على التوالي.بينما تضمن القسم الثاني من هذا العمل قياس الفعالية الحيوية للمخلبيات المحضرة تجاه Gram + ve bacteria Staphylococcus Aureus (ATCC 25923), Gram – ve bacteria Escherischia Coli (ATCC 225922), Pseudomonas Aaruginosa (ATCC 27853), and against fungi Candida Albicans (ATCC 10231), حيث أظهر المركب (5) فقط وعند تركيز 5 جزء بالمليون فعالية واضحة تجاه + ve bacteria Staphylococcus Aureus و – ve bacteria Escherischia Coli.

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