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Article
Anti-Liver membrane Antibody predict outcome of Autoimmune Hepatitis

Authors: Akram A. Najeeb --- Batool A. Al-Haidary --- Eman Sh. AL- Obeidy
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 / 24108057 Year: 2008 Volume: 50 Issue: 3 Pages: 395-399
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Autoantibodies against liver membrane are the specific
autoantibodies found in AIH. Cytochrome P450 1A2 has been identified as the
target autoantigen for these autoantibodies
The aim of the study : is to evaluate the prevalence and clinical relevance of
LMA in AIH
Methods: The study was performed on 73 Iraqi patients with chronic active hepatitis
(CAH) of unknown cause , attending the teaching hospital for gastroenterology and
liver disease in a period between November 2003 and July 2004. Anti-liver membrane
antibodies were studied by IFA technique.
Results: LMA was detected in the sera of 28(57.14)and 3(37.5%) patients with type 1
and type 3 AIH respectively, but never in the sera of healthy group .
Conclusion: It was concluded that LMA is present in type-1 and type-3 AIH but not in
sera of patients with type-2 or in healthy control group.

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