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OIL EXTRACT OF LORANT H US E UROPE US SEEDS PROMOTES WOUND HEALING
المستخلص الزيتي لبذور نبات حب الدبق يشجع التئام الجروح

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Abstract

The efficacy of oil extract of the seeds of Loranthus europeus on wound healing wasinvestigated. After the preparation of the oil extract, the oil ointment of L. europeus wasprepared. A preliminary biochemical analysis were carried out to find out the chemicalcontents of L. europeus oil extract. The study involved 18 male rabbits, they were dividedequally and randomly into 3 groups depending on post wounding biopsy: p(3'd,7Ih and l4‘hdaypost wounding). Two full thickness cut wounds were done on the both sides of shoulderregions( the left wound as control and the left as treated wound) of each group of animals.The treated and control wounds were treated continuously with (0.5mg) oil ointment andVaseline base respectively, for 14”‘ day twice a day. All wounds were evaluatemacroscopically which included "measurement of contraction rate, daily wound contraction,hyperemia, exudation and scab formation." and microscopically for "neutrophil, macrophageinfiltration, re-epithelization, fibroblast proliferation with collagen production and new bloodcapillary formation". ABoth macroscopic and microscopic results showed the efficacy of L europeus seeds inpromoting the healing process significantly as compared with control wounds (P<0.05). Theoil extract treated wounds showed significant increase in hyperemia, exudation and scabformation, neutrophils and macrophages infiltration, fibroblast proliferation with collagenproduction and formation of new epithelium (re-epithelization), contraction rate and dailywound contraction at 3”’ day post wounding, as compared with control wounds, but thesecategories showed reduction at 7”‘ day except in macrophages, re—epithelization and‘ fibroblast with collagen production which all showed significant increase at 7"‘ and 14"‘ dayspost wounding as compared with control wounds. The preliminary chemical analysis foroil extract showed the presence of Glycosides, Carbohydrates, Aldehydes & Ketones,Trifrepenoides groups, protein and Polysaccharides, while Alkaloides, Flavonoides andSaponins are absent.

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