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EFFECT OF CHITOSAN SHEETS ON WOUND HEALING
تاثير رقائق الكايتوسان على شفاء الجروح

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Abstract

The study was aimed to evaluate the effect ofchitosan sheets on wound healing process andits activity as a wound dressing materials. Accordingly chitosan sheet was isolated and preparedfrom the exoskeleton of the native shrimps in Basrah Province. Twenty-four male rabbits wereused and two full-thickness circular cuts (2cm in diameter) were made on the dorsal aspect ofeach rabbit. The healing process was evaluated macroscopically by evaluation of the properties ofchitosan sheets on wound in terms of (adherence, absorption, and fluid accumulation) on differentintervals (i.e.lSt,3’d,7‘h,and 15"‘ post wounding day). On the other hand the contraction rate in testedliand control wounds were evaluated during different intervals (i.e. at lS‘,3' ,7‘ ,and I5“ post woundingday).The healing process was evaluated microscopically in terms of (infiltration of neutrophils andmacrophage infiltration, new blood vessels and fibroblast proliferation and Re—epithelialization).. The result of macroscopic evaluation showed that chitosan sheets were firmly adherent to' . the wound with underlying mild fluid accumulation during the first three post wounding day. At, the same time the sheets started to disappear and completely absorbed at 7' day after woundbreation. The result of the effect of the chitosan sheet on wound contraction demonstrated that thebontraction rate of tested wounds was significantly higher than in control wounds through thelperiod of experiment. In the treated group complete wound closure with contraction rate of 100%was reached at 103‘ post wounding day while the control wounds failed to close completely till the’ lend of experiment at 15‘ day. The results of microscopic evaluation of wound healing process weredemonstrated significant increase (p<0.05) infiltration of neutrophils in test wound at the first post‘wounding day then decrease and completely disappear while persist in control wound. Infiltrationof macrophages significantly increased (p<0.05) in tested wound during the period of experiment.§The fibrovascular granulation tissue and Re-epithelialization significantly more obvious in testediwound than in control wound through the period of experiment (p<0.050).

Keywords

Chitosan --- Epithelization --- wounds

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2007 (1)