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ANTIOXIDANT, ANTIDIABETIC AND LIPID LOWERING EFFECTS OF CINNAMON AND VITAMIN C IN HYPERGLYCEMIC RABBITS
تأثير مضادات الاكسدة والسكري والخافضة للكوليسترول للدارسين وفيتامين C على الارانب المصابة بفرط السكر

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Abstract

The study was done to evaluate the antioxidant effects of cinnamon and vitamin Cin controlling hyperglycemia and their effect on lipid profile in male rabbits incomparison with the effects of insulin therapy and control animals.Twenty four diabetic rabbits by the injection of alloxan 100 mg/kg body weightin the marginal vein of the ear. These diabetic rabbits were divided randomly into 4groups Number of animals in each group = 6:Group 1: Was given 2 I.U/ animal of insulin subcutaneously daily. Group 2: Wasgiven ground cinnamon orally 300 mg/kg body weight dissolved in 5 ml normalsaline daily. Group 3: Was given vitamin C orally 200 mg/kg body weight dissolvedin 5 ml normal saline daily. Group 4: Received orally 5 ml normal saline (0.9% Nacl)daily and considered as control group. All animal groups were treated for five weeks.Blood samples were taken from these groups weekly for biochemical analysis toestimate: Blood glucose, Lipid profile (include total cholesterol (TC), triglyglyceride(TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and very lowdensity lipoprotein(VLDL) and serum malondialdehyde (MDA).The results showed high glucose and lipid concentration associated with anincreased oxidant stress alloxan induces on diabetic animals.The statistically analysis showed that a cinnamon and vitamin C significant (P<0.05) reduction in glucose and lipid profile (TC, TG, HDL, LDL and VLDL) inconcordance with a significant elevation in HDL (P<0.05). The level of MDA wasalso significantly reduced (P<0.05) in all period comparison with period beforetreated with vit. C and Cinnamon extract.It may conclude that, cinnamon and vitamin C have antioxidant activities to causean important role in reduction of blood glucose level and lipid profile inhyperglycemic animals.

الخلاصة اجريت هذه الدراسة لتقيم التاثير المضاد للاكسدة للدارسين وفيتامي. المجموعة الثالثة ن C في السيطرة على فرط السكر وتاثيرهما على صور الدهون في ذكور الفئران البالغة مقارنتاً مع تأثيرهما بالعلاج بالانسولين وحيوانات السيطرة. بعد زرق الحيوانات بالالوكسان (100ملغم/كغم من وزن الجسم) في الوريد الجافي للاذن. هذه الارانب قسمت عشوائي الى اربعة مجاميع (كل مجموعة تحوي ستة حيوانات). المجموعة الاولى زرقت تحت الجلد (وحدتان دوليتان/حيوان) انسولين). المجموعة الثانية جرعت فموياً (300غم/ كغم) الدارسين المطحون المذاب بـ(5مل) من المحلول الفسيولوجي

Keywords

antioxidant --- alloxan --- lipid


Article
ANTIOXIDANT, ANTIDIABETIC AND LIPID LOWERING EFFECTS OF CINNAMON AND VITAMIN C IN HYPERGLYCEMIC RABBITS
تأثير مضادات الاكسدة والسكري والخافضة للكوليسترول للدارسين وفيتامين C على الارانب المصابة بفرط السكر

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Abstract

The study was done to evaluate the antioxidant effects of cinnamon and vitamin Cin controlling hyperglycemia and their effect on lipid profile in male rabbits incomparison with the effects of insulin therapy and control animals.Twenty four diabetic rabbits by the injection of alloxan 100 mg/kg body weightin the marginal vein of the ear. These diabetic rabbits were divided randomly into 4groups Number of animals in each group = 6:Group 1: Was given 2 I.U/ animal of insulin subcutaneously daily. Group 2: Wasgiven ground cinnamon orally 300 mg/kg body weight dissolved in 5 ml normalsaline daily. Group 3: Was given vitamin C orally 200 mg/kg body weight dissolvedin 5 ml normal saline daily. Group 4: Received orally 5 ml normal saline (0.9% Nacl)daily and considered as control group. All animal groups were treated for five weeks.Blood samples were taken from these groups weekly for biochemical analysis toestimate: Blood glucose, Lipid profile (include total cholesterol (TC), triglyglyceride(TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and very lowdensity lipoprotein(VLDL) and serum malondialdehyde (MDA).The results showed high glucose and lipid concentration associated with anincreased oxidant stress alloxan induces on diabetic animals.The statistically analysis showed that a cinnamon and vitamin C significant (P<0.05) reduction in glucose and lipid profile (TC, TG, HDL, LDL and VLDL) inconcordance with a significant elevation in HDL (P<0.05). The level of MDA wasalso significantly reduced (P<0.05) in all period comparison with period beforetreated with vit. C and Cinnamon extract.It may conclude that, cinnamon and vitamin C have antioxidant activities to causean important role in reduction of blood glucose level and lipid profile inhyperglycemic animals.

الخلاصة اجريت هذه الدراسة لتقيم التاثير المضاد للاكسدة للدارسين وفيتامي. المجموعة الثالثة ن C في السيطرة على فرط السكر وتاثيرهما على صور الدهون في ذكور الفئران البالغة مقارنتاً مع تأثيرهما بالعلاج بالانسولين وحيوانات السيطرة. بعد زرق الحيوانات بالالوكسان (100ملغم/كغم من وزن الجسم) في الوريد الجافي للاذن. هذه الارانب قسمت عشوائي الى اربعة مجاميع (كل مجموعة تحوي ستة حيوانات). المجموعة الاولى زرقت تحت الجلد (وحدتان دوليتان/حيوان) انسولين). المجموعة الثانية جرعت فموياً (300غم/ كغم) الدارسين المطحون المذاب بـ(5مل) من المحلول الفسيولوجي

Keywords

antioxidant --- alloxan --- lipid

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