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Article
Evaluation the Level of Dieldrin and Heptachlor in Iraqi People

Author: Alaa H. Jawad
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2017 Volume: 20 Issue: 3 Pages: 24-29
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Organochlorine pesticides for whatever length of time that been extensively utilized as a part of farming and in public health as highly effective pest control agents.They are lipophelic and have drawn out a half-existences of years to decades; thus, they amass in human fat tessues and a can bring about endless poisonous quality after long term exposure.To detect and measure the concentrations of organochlorine pesticides, (Dieldrin and Heptachlor) in serum and fatty tissue samples and studies their correlation with lipids in order to reveal the need. for human monitoring.The study was conducted on 50 samples of blood and fatty tissues to determine their lipid concentrations and detect metabolites of organochlorine pesticides and asses their1correlations using HPLC.The study observed that there were raised serum concentrations of lipids which were positively corresponded with lifted serum convergences of Dieldrin and Heptachlor pesticides.Mean serum concentrations of triglycerides was inside “normal” range while mean serum of aggregate cholesterol was hoisted above ordinary range. Rate of grouping of lipid to serum Dieldrin was higher than that of Heptachlor in living subjects.

Keywords

Dieldrin --- Heptachlor --- Pesticides.


Article
The Consequences of Terrorist and Military Operations in Three Regions of Baghdad, Iraq on Serotonin and Thyroid Function

Author: Alaa H. Jawad
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2018 Volume: 21 Issue: 2 Pages: 32-36
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

In this paper the effect of terrorist and military operations in three regions of Baghdad, Iraq were studied on thyroid gland function and serotonin hormones, in 75 Iraqi individual from (AL-karradah and Abo-Gharib) regions as comparison with Al-jadria (control). The correlation between sera thyroid hormones thyroxine T4, triiodothyronine T3, thyrotropin TSH and serotonin have been indicated‎, the utilization of thyroid hormones as a compelling subordinate treatment for full of feeling issue has been contemplated in the course of recent decades and has been adjusted more than once. Communication of the thyroid and monoamine neurotransmitter frameworks has been recommended as a potential underline component of action. The serotonin framework has been moderately ignored, along these lines; the objective of this article is to audit the writing on the connection between thyroid hormones and the mind serotonin. Our examination proposes a negatively relationship between serotonin and thyroid stimulating hormones (TSH), a positive ‎correlation between serotonin and thyroxine‎, while there were significant positive correlations between serotonin and triiodothyronine. In conclusion, there is powerful confirmation, that the thyroid economy has a balancing sway in the brain serotonin system, thus considerable further investigation will be necessary to understand the role of serotonin in the pathogenesis and high levels in the some regions in Iraq such as AL-karradah and Abo-Gharib.

Keywords

Serotonin --- thyroid hormones --- T3 --- T4 --- TSH --- pollution --- Baghdad area.


Article
Impact of Some Heavy Metals and BPA Resulting from Terrorist Operations in Three Regions of Baghdad, Iraq on Serotonin‎

Author: Alaa H. Jawad
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2018 Volume: 21 Issue: 4 Pages: 10-15
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

In this paper the effect of terrorist operations in three regions of Baghdad, Iraq were studied on serotonin hormones, in 75 Iraqi individual from (AL-karradah and Abo-Gharib) regions as comparison with Al-jadria as (a control). The correlation between sera serotonin and the levels of lead (Pb), cadmium (Cd), mercury (Hg) and bisphenol-A(BPA) have been selected for study, relation of heavy metals, BPA and monoamine neurotransmitter frameworks has been recommended as a potential underline component of action. The serotonin framework has been moderately ignored, along these lines; the objective of this article is to audit the writing on the connection between heavy metals, BPA and the serotonin. Our examination proposes a positive ‎correlation between serotonin and the levels of lead (Pb), cadmium (Cd), mercury (Hg) and BPA. In conclusion, that serotonin levels in the area of (Al-karadah, Abo-Gharib) pollutants areas were high as compared with the control (Al-jadria) as the lowest percentage of pollution. Thus considerable further investigation will be necessary to understand the role of serotonin in the pathogenesis and high levels in the some regions in Iraq such as AL-karradah and Abo-Gharib.


Article
Effects of Metformin and Metformin Plus Glibenclamide on Glucose-6-Phosphatase Status and Some Biochemical Parameters in Type 2 Diabetic Patients

Authors: Zainab S. Hallab --- Alaa H. Jawad --- Perry H. Saifullah
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2016 Volume: 19 Issue: 2 Pages: 18-24
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

This research was done to assess the effects of anti diabetic drugs (metformin and metformin plus glibenclamide) on Glucose-6-phosphatase activity, serum leptin concentration, Fasting plasma glucose (FPG), Glycated hemoglobin (HbA1c%) and lipid profile in type 2 diabetic patients. The study involved 64 patients suffering from type 2 diabetes mellitus. They were divided into 3 groups. The first group involves 23 newly diagnosed diabetic patients, who did not take any hypoglycemic agents. The second group involves 21 patients on metformin monotherapy, whereas the third group involves 20 patients on metformin plus glibenclamide combination therapy. Another group which involved 20 apparently healthy subjects was used as control group. Age, Body mass index (BMI), FPG, HbA1c %, lipid profile, Glucose-6-phosphatase activity and serum leptin concentration have been determined. The results showed that the activity of Glucose-6-phosphatase was lower in metformin and metformin plus glibenclamide groups when compared with newly diagnosed group and closer to that of control group, leptin concentration was lower in metformin group than that in metformin plus glibenclamide group and these two groups were lower than newly diagnosed group, the levels of FPG, HbA1C% were reduced in metformin and metformin plus glibenclamide groups when compared with newly diagnosed group and metformin alone produce a non-significant favorable effect on all lipids profile parameters, while metformin plus glibenclamide showed a significant reduction in Total Cholesterol (TC) and Low Density Lipoprotein LDL-C. In conclusion, using metformin as a mono therapy or combination with glibenclamide can reduce Glucose-6-phosphatase activity, FPG and HbA1c% levels in type 2 diabetic patients and metformin monotherapy reduced leptin levels more than metformin combination with glibenclamide in type 2 diabetic patients patients so Glucose-6-phosphatase activity and serum leptin concentration can be used as an indicator for the choice of treatment in those diabetic patients.

أجريت هذه الدراسة لتقييم آثار العقاقير المضادة لمرضى السكري على فعاليه الجلوكوز-6- فوسفاتيز، تركيز هرمون اللبتين, مستوى السكر في بلازما الدم، نسبه التراكمي للسكر ومستوى الدهون في مرضى السكري من النوع الثاني. وشملت الدراسة 64 مريضا يعانون من داء السكري من النوع الثاني. تم تقسيمهم إلى ثلاث مجاميع اعتمادا على نوع العلاج المستخدم, تشمل المجموعة الأولى 23 مريضا تم تشخيصهم حديثا من دون اخذ أي نوع من العلاج وتشمل المجموعة الثانية 21 مريضا تمت معالجتهم بعقار الميتفورمين، والمجموعة الثالثة تشمل 20 مريضا تمت معالجتهم بعقار الميتفورمين مع الجلايبينكلامايد تم استخدام مجموعة أخرى التي شملت 20 شخصا أصحاء كمجموعة تحكم العمر، مؤشر كتلة الجسم، مستوى السكر، نسبة التراكمي للسكر، مستوى الدهون، فعاليه الجلوكوز-6- فوسفاتيز وتركيز هرمون الليبتين تم تحديدهم. أظهرت النتائج أن فعاليه الجلوكوز-6- فوسفاتيز كان أقل في المجموعات التي تتناول العلاج بالمقارنة مع المجموعة التي تم تشخيصها حديثا وأقرب إلى قيم المجموعة الضابطة، وكان تركيز هرمون الليبتين أقل في مجموعة الميتفورمين من مجموعه الميتفورمين مع الجلايبينكلامايد وكانت هاتين المجموعتين أقل من المجموعة التي تم تشخيصها حديثا. مستويات السكر، ونسبه التراكمي للسكر انخفضت في المجموعات التي تتناول العلاج بالمقارنة مع المجموعة التي تم تشخيصها حديثا. الميتفورمين وحده إحدث تأثير إيجابي غير كبير على جميع الدهون، في حين أن استخدام الميتفورمين مع الجلايبينكلامايد أدى الى انخفاض كبير في مستوى TC و LDL-C. في الختام، استخدام الميتفورمين كعلاج أحادي أو بالاشتراك مع الجلايبينكلامايد يمكن أن يقلل من فعاليه الجلوكوز-6-فوسفاتيز، مستوى السكر في الدم ونسبة التراكمي للسكر في مرضى السكر من النوع الثاني و الميتفورمين وحده يخفض مستويات هرمون الليبتين أكثر من الميتفورمين مع الجلايبينكلامايد في مرضى السكري من النوع الثاني لذلك فعاليه الجلوكوز-6- فوسفاتيز وتركيز هرمون الليبتين يمكن أن يستخدم كمؤشر لاختيار العلاج في هذا النوع من المرضى.


Article
4-Hydroxy-2-Nonenal, Indused Nitric Oxide Synthase Statues in Hypertension Patients

Authors: Ali D. Hammed --- Alaa H. Jawad --- Perry H. Saifullah
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2017 Volume: 20 Issue: 3 Pages: 6-11
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

The oxidative stress is one of the main cause for cardiovascular diseases (like Hypertension) also one of the results of these diseases. This study involved 56 subjects matched ages and sex divided into two groups; 28 hypertensive subject and 28 healthy subject as control group. The following analysis was done: 4-Hydroxy-2-nonenal (4HNE), Induced nitric oxide synthase (iNOS) and albumin. The results show that there is a significant increase in (4HNE) between patients group and control group. INOS was significantly higher in patients compared to controls while there were no significant difference found in albumin between patient and control group. The increase in 4HNE which is a product of lipid peroxidation is attributed to destruction in body cell caused by due to the increase in stress events. And the increase in iNOS because iNOS produces large amounts of NO as a defense mechanism in response to cytokines and is an important factor in the response of the body to attack by parasites, bacterial infection, and tumor growth. It has been concluded that is important nappy on ideal weight, because obesity considered main factors for heart disease and hardening of the arteries. There is a positive relationship between oxidation results from hypertension and their developments. The aim of this study was to investigate the relationship between of some oxidative stress markers and cardiovascular diseases


Article
The Consequences of Heavy Metals Resulting from Terrorist Operations in Three Regions of Baghdad, Iraq on Thyroid Function

Authors: Sara J. Kadhim --- Alaa H. Jawad --- Perry H. Saifullah
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2018 Volume: 21 Issue: 2 Pages: 10-17
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

The heavy metals mercury (Hg), lead (Pb) and cadmium (Cd) are widely known of being toxicants. exposure to a variety of dangerous toxic effects has been attached in all humans.in this paper the effect of terrorist operation on thyroid gland functions in a sample of Iraqi individual (Al-karradah and Abo-Gharib) comparison with Al-jadria rejoin as (control). the correlation between sera thyroid hormones thyroxine T4, triiodothyronine T3, Thyrotropin TSH and Thyroglobulin-Ab (Tg-Ab) and the levels-of lead, cadmium, also mercury have-been measured. 75 volunteers from three Iraqi areas were included in this study‎. our examination proposes an inverse relationship between Hg presentation and thyroid hormones, a positive ‎correlation between Cd exposure and thyroid hormones‎, but the associations with Pb was negative. there were significant positive correlations between the heavy metals themselves. In this manner, increased heavy metals exposure might be a factor in the etiology of hypothyroidism diseases ‎and thyroid gland function. the result of this study showed that the effect of heavy metals (blood serum Hg, blood serum Pb, blood serum Cd) on thyroid hormones, and the effect of military and terrorist operations on the thyroid gland. In the end we concluded that the heavy elements resulting from the explosions and terrorist operations in the area of (Al-karadah, Abo-Gharib) high compared with the control (Al-jadria), this leads to many diseases on the health of the human body and also the effect of heavy elements on the thyroid gland and its negative effect on thyroid hormones and cause thyroid disease


Article
Effect of Body Mass Index on Abnormal Ovarian Secretion Hormones among Iraqi Women with Polycystic Ovarian Syndrome (PCOS)

Authors: Alaa H. Badr --- Alaa H. Jawad --- Rania M. L. Faraj
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2019 Volume: 22 Issue: 1 Pages: 40-45
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Polycystic ovarian syndrome (PCOS) is the most common and complex endocrine disorder affecting women in the reproductive age. The etiology of this syndrome is not completely known, so there is a developing proof that supports genetic basis, PCOS has a strong familial preference. This study was carried out to investigate the effect of body mass index (BMI) on ovarian hormones in women with PCOS and healthy women. Eighty-three women aged (17-40) years were divided into two groups for testing (BMI less than 25 and more than 25). Hormonal study of Luteinizing hormone (LH), Androgen, Estradiol (E2) was done for each patient, the results of these hormones in patients compared with controls in both BMI groups with E2/T ratio showed a significant increase in patients women compared to controls in (p<0.05), While the results of Follicle stimulating hormone (FSH) and Total Testosterone (TT) showed an increase with not statistically significant. it has been concluded that the increase in BMI doesn’t show to have an opposite effect on FSH, Androgen, E2, and TT levels but the result of LH shows a highly significant increase in PCOS groups compared to controls when BMI˃25.

Keywords

Polycystic ovarian syndrome --- LH --- E2 --- FSH --- TT --- BMI --- ovarian hormones --- Androgen.


Article
A Study of the Correlation of Some Sex Hormone with Obesity in Women with Secondary Infertility

Authors: Alaa H. Jawad --- Suhad A. Ibrahim --- Zyad H. Jawad --- Donya M. Hadi
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2015 Volume: 18 Issue: 2 Pages: 44-49
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Infertility is the inability to conceive a child for more than one year. The present study indicates that the obesity associated with infertility. The aim of the study to determine follicle stimulating hormone, luteinizing hormone, testosterone hormone and prolactin levels. and cholesterol and triglyceride concentration in 2nd inferetid women. This study was carried out at kamal al-samaarai hospital the data were collected from 95 secondary infertilial women were age between 16-45 years old and grouped them in to obese (n = 46) and non obese(n = 49). There was no significant difference between the two groups (p< 0.05). Body mass index in Infertile obese women is slightly higher than non obese Infertile women which is statistically significant (P<0.001). However LH, TSH, cholesterol and triglyceride concentration in obese infertile women is significantly higher than non obese infertile women (p> 0.05).The BMI was correlated positively with triglyceride in obese group while BMI was positive correlation highly significant with cholesterol in non obese group. Regression analysis revealed obese to be strongly associated with observed infertility. The elevated prolactin values in secondary infertile women clearly shows that there is a mechanism operating at the anterior pituitary level which shows an abnormal distribution of FSH and LH which may further explain the abnormal delay ovum maturation. This study also indicates obese associated with infertile more than non obese women.

العقم هو عدم قدرة المرأة على انجاب طفل.تشير هذه الدراسة الى علاقة السمنة المفرطة مع العقم لتحديد هرمون اللوتيني (LH)، هرمون المنبه للجريب (FSH)، التيستستيرون والبرولاكتين ،وكذلك تركيز الكوليستيرول والدهون الثلاثية، اجريت هذه الدراسة في مستشفى كمال السامرائي، وقد تم جمع البيانات من 95 امراة بالعقم الثانوي وكانت اعمارهن تتراوح بين (16-45) سنة وتم تقسيمهن الى مجموعتين: (البدناء 46 =n) وغير البدناء (9 4= n). أظهرت النتائج عدم وجود اختلاف معنوي بين النساء البدينات وغير البدينات لهرمون المنبه للجريب (FSH)، التستيستيرون، والبرولاكتين في نساء البدينات. اللاتي يعانين من العقم مقارنة بالنسـاء غير البدناء ليس اعلى بكثير (p >0.05) مؤشر كتلة الجسم للنساء البدينات اللاتي يعانن من العقم مقارنة بالنساء غير البدناء كانت اعلى بقليل (p < 0.001). ومـع ذلك ان نسبـة هرمـون اللوتينـي، هرمون المحفز للغدة الدرقية، الكوليسترول، والدهون الثلاثية في النساء البدينات اللاتي يعانن من العقم هي اعلى بكثير مما كانت عليه في النساء الغير بدينات (p< 0.05) أظهر مؤشر كتلة الجسم علاقة ايجابيه هامة للغاية مع الدهون الثلاثية في مجموعة البدناء في حين كان مؤشر كتلة الجسم علاقة ايجابية هامة للغاية مع الكوليستيرول في المجموعة غير البدناء. واظهرت لنا التحليلات بان السمنة المفرطة لها علاقة مباشرة مع العقم. قيم البرولاكتين المرتفعة لدى النساء المصابات بالعقم الثانوي يبين بوضوح ان هناك الية تعمل على مستوى الفصى الامامي لغدة النخامية التي يظهر التوزيع الغير طبيعي للهرمون اللوتيني وهرمون المنبه للجريب الذي قد يبين سبب تاخير نضوج البويضة.


Article
Study of Some Markers of Oxidative Stress Statues in Cardiovascular Disease Patients

Authors: Yasmeen Muhialdeen H. --- Alaa H. Jawad --- Wisam Kadhum H. Al-Hashemi
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2015 Volume: 18 Issue: 3 Pages: 38-43
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

The oxidative stress is one of the main cause for cardiovascular diseases and also one of the results of these diseases, its development. The aim of this study was to investigate the relationship between of some oxidative stress markers and cardiovascular diseases. This study involved 84 samples matched ages and sex divided into groups; 28 samples cardiovascular and 28 hypertensive in addition to 28 healthy control group. The following analysis were done: lipid profile, malondialdehyde (MDA), and albumin. The results show there is a significant increase in lipid profile between each group and control group. MDA was significantly higher in patients compared to controls whereas no significant difference was found in albumin between patient and control groups. The increase in MDA which is a product of lipid peroxidation is attributed to destruction in body cell caused by free radicals and resulting oxidative stress. It has been concluded that the assessing the lipid ratios is important even in a normal individual as it is one of the factors for development of cardiovascular diseases and their complications. There is a positive relation between oxidation results from these diseases and their developments.

الجهد التاكسدي هو احد الاسباب الرئيسية لامراض القلب واوعيته وهو ايضا احد نتائج تقدم هذه الامراض والتحطم الناتج منها. هدف هذه الدراسة هو بحث العلاقة بين مؤشرات الجهد التاكسدي وامراض القلب واوعيته. هذه الدراسة استلزمت 84 عينة من النساء قسمت الى 28 عينة مرضى بامراض القلب واوعيته و 28 بأمراض ضغط الدم بالإضافة الى 28 من الاصحاء كمجموعة سيطرة. التحليلات التالية اجريت لكل العينات: صورة الدهون، المالون داي الديهايد، والالبومين. النتائج اظهرت ان هناك زيادة معنوية في مستويات صورة الدهون بين كل مجموعة ومجموعة السيطرة. المالوندايالديهايد اعلى بشكل معنوي في المرضى مقارنة بمجموعة السيطرة بينما لم يظهر اي فرق معنوي في الالبومين. الزيادة في المالون داي الديهايد والذي هو ناتج فوق اكسدة الدهون يعزى الى التحطم في خلايا الجسم بسبب الجذور الحرة الناتجة من الجهد التاكسدي. الاستنتاج: اهمية تقييم نسب الدهون حتى في الاصحاء كونها احد عوامل تطور امراض القلب واوعيته وتعقيداته. هذه العلاقة الموجبة بين الاكسدة الناتجة من هذه الامراض وتفاقمها. وبالتالي يقترح زيادة تناول مضادات الاكسدة للحد من هذه الامراض او تفاقمها.


Article
Study Oxidative Stress Statues In Hypertension Women
دراسة مستويات الاجهاد التأكسدي عند المريضات بارتفاع ضغط الدم

Authors: Yasmeen Muhi Aldeen ياسمين محي الدين --- Perry Habeeb بري حبيب --- Alaa H. Jawad علاء حسين جواد
Journal: Baghdad Science Journal مجلة بغداد للعلوم ISSN: 20788665 24117986 Year: 2016 Volume: 13 Issue: 2ملحق ابحاث المؤتمر الوطني الثاني للكيمياء Pages: 407-413
Publisher: Baghdad University جامعة بغداد

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Abstract

The oxidative stress is result of unbalancing between oxidants and antioxidants in the body. Hypertension (HT) is a measure of average systolic blood pressure which created by the heart contracting, greater ≥140 mmHg or an average diastolic blood pressure, which is the heart fills, of ≥equal to 90 mmHg. The study is conducted on 28 female patients with HT from Ibn Al-nafese hospital in addition to 28 female control. The markers measured are albumin, malondialdehyde (MDA) and 8-Hydroxy deoxyguanosine (8-OHdG). Also electrophoresis study on extracted DNA with Fenton reaction was done. Results of this study show there are high significant decrease (p≤0.01) in albumin concentration of patient related to control, and there is a high significant increase (p≤ 0.01) in each MDA and 8-OHdG for patients group in comparison with controls. The Fenton reaction done shows that oxidant has degradation effect on DNA either in two minutes of reaction. It is concluded that oxidative stress in its parameter (albumin) and markers (MDA and 8-OHdG) is main chemical manifestation of group under study. And oxidants produced by Fenton can denature the DNA in vitro.

الاجهاد التأكسدي هو نتيجة لعدم التوازن بين توليد المؤكسِدات و مضادات الأكسدة في الجسم وارتفاع ضغط الدم هو مقياس لمعدل الضغط الانبساطي ≥ 140 ملم زئبق والانقباضي ≥ 90 ملم زئبق. هدف الدراسة هو دراسة الاجهاد التأكسدي في مريضات ضغط الدم وفحص تأثير تفاعل فنتون على الحامض النووي خارج الجسم. تضمنت هذه الدراسة 28 عينة من امرأة مريضة بمرض ضغط الدم من مستشفى ابن النفيس اضافة الى 28 امرأة سليمة كمجموعة سيطرة وتم اجراء قياسات الالبومين والمالون داي الدهايد و8 هيدروكسي ديوكسي كوانوسين كما تم اجراء الترحيل الكهربائي للحامض النووي بعد تفاعل فنتون عليه. أظهرتْ النتائج المقارنة مع الاصحاء ان هناك هبوطا معنويا (0.01 ≥p) في مستويات الالبومين . بينما سجلت مستويات المالون داي الدهايد و8 هيدروكسي ديوكسي كوانوسين ارتفاعا معنويا عاليا (0.01 ≥p) مقارنة بمجموعة السيطرة. واظهر الترحيل الكهربائي تحطم الحامض النووي بعد تعرضه للأكسدة بواسطة تفاعل فنتون. يُستنتج ان الجهد التأكسدي بمعامله الظاهرة بشكل البومين او علاماته كالمالون داي الدهايد و8 هيدروكسي ديوكسي كوانوسين هي المظهر للأكسدة في المجموعة تحت الدراسة. والأكسدة لها تأثير كبير عل الحامض النووي في خارج الجسم

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