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Study Oxidative Stress Statues In Hypertension Women
دراسة مستويات الاجهاد التأكسدي عند المريضات بارتفاع ضغط الدم

Authors: Yasmeen Muhi Aldeen ياسمين محي الدين --- Perry Habeeb بري حبيب --- Alaa H. Jawad علاء حسين جواد
Journal: Baghdad Science Journal مجلة بغداد للعلوم ISSN: 20788665 24117986 Year: 2016 Volume: 13 Issue: 2ملحق ابحاث المؤتمر الوطني الثاني للكيمياء Pages: 407-413
Publisher: Baghdad University جامعة بغداد

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Abstract

The oxidative stress is result of unbalancing between oxidants and antioxidants in the body. Hypertension (HT) is a measure of average systolic blood pressure which created by the heart contracting, greater ≥140 mmHg or an average diastolic blood pressure, which is the heart fills, of ≥equal to 90 mmHg. The study is conducted on 28 female patients with HT from Ibn Al-nafese hospital in addition to 28 female control. The markers measured are albumin, malondialdehyde (MDA) and 8-Hydroxy deoxyguanosine (8-OHdG). Also electrophoresis study on extracted DNA with Fenton reaction was done. Results of this study show there are high significant decrease (p≤0.01) in albumin concentration of patient related to control, and there is a high significant increase (p≤ 0.01) in each MDA and 8-OHdG for patients group in comparison with controls. The Fenton reaction done shows that oxidant has degradation effect on DNA either in two minutes of reaction. It is concluded that oxidative stress in its parameter (albumin) and markers (MDA and 8-OHdG) is main chemical manifestation of group under study. And oxidants produced by Fenton can denature the DNA in vitro.

الاجهاد التأكسدي هو نتيجة لعدم التوازن بين توليد المؤكسِدات و مضادات الأكسدة في الجسم وارتفاع ضغط الدم هو مقياس لمعدل الضغط الانبساطي ≥ 140 ملم زئبق والانقباضي ≥ 90 ملم زئبق. هدف الدراسة هو دراسة الاجهاد التأكسدي في مريضات ضغط الدم وفحص تأثير تفاعل فنتون على الحامض النووي خارج الجسم. تضمنت هذه الدراسة 28 عينة من امرأة مريضة بمرض ضغط الدم من مستشفى ابن النفيس اضافة الى 28 امرأة سليمة كمجموعة سيطرة وتم اجراء قياسات الالبومين والمالون داي الدهايد و8 هيدروكسي ديوكسي كوانوسين كما تم اجراء الترحيل الكهربائي للحامض النووي بعد تفاعل فنتون عليه. أظهرتْ النتائج المقارنة مع الاصحاء ان هناك هبوطا معنويا (0.01 ≥p) في مستويات الالبومين . بينما سجلت مستويات المالون داي الدهايد و8 هيدروكسي ديوكسي كوانوسين ارتفاعا معنويا عاليا (0.01 ≥p) مقارنة بمجموعة السيطرة. واظهر الترحيل الكهربائي تحطم الحامض النووي بعد تعرضه للأكسدة بواسطة تفاعل فنتون. يُستنتج ان الجهد التأكسدي بمعامله الظاهرة بشكل البومين او علاماته كالمالون داي الدهايد و8 هيدروكسي ديوكسي كوانوسين هي المظهر للأكسدة في المجموعة تحت الدراسة. والأكسدة لها تأثير كبير عل الحامض النووي في خارج الجسم


Article
8.4-Hydroxy-2-nonenal, Induced Nitric Oxide Synthase Status in Hypertension with Kidney Disease Patients

Authors: Ali D. Hammed علي ظافر حميد --- Alaa H. Jawad علاء حسين جواد --- Noor M. Ali نور مصطفى علي
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2019 Volume: 17 Issue: 2 Pages: 146-152
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:The oxidative stress is one of the main reasons for cardiovascular diseases and also one of results of these diseases, its development (like kidney disease).Objective:To identify the effect of oxidative stress nitric oxide and reactive oxygen species on cardiovascular diseases.Methods:The study involved 56 subjects comparable in age and sex divided into two groups; 28 hypertensives subjects with kidney disease and 28 apparently healthy subjects as control group. The following analysis was done: 4-Hydroxy-2-nonenal (4HNE), Induced nitric oxide synthase (iNOS) and albumin.Results:There was a significant increase in (4HNE) between patients' group and control group. iNOS was significantly higher in patients as compared to controls while there were no significant differences found in albumin between patient and control group. There is a positive relationship between oxidation results from hypertension and their developments. There is a positive correlation between BMI and disease.Conclusion:Based on this study is important on ideal weight, because obesity considered main factors for heart disease and hardening of the arteries. In addition, the effect of oxidative stress, which leads to high blood pressure and thus chronic kidney disease.Keywords;Chronic kidney disease, hypertension, 4-Hydroxy-2-nonenal (4HNE), Induced nitric oxide synthase (iNOS), albumin, creatinine, reactive oxygen speciesCitation:Hammed AD, Jawad AH, Ali NM. 4-Hydroxy-2-nonenal, induced nitric oxide synthase status in hypertension with kidney disease patients. Iraqi JMS. 2019; 17(2): 146-152. doi: 10.22578/IJMS.17.2.8

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