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CHLAMYDIA PNEUMONIAE: THE POTENTIAL CAUSE OF MULTIPLE SCLEROSIS

Authors: Alaa H. Khaliel علاء حسن خليل --- Ahmed A.H. Abbas احمد عبد الحسن عباس
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2016 Volume: 14 Issue: 2 Pages: 131-136
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:Multiple sclerosis is an autoimmune disease, its etiology until know is unknown. Many studies suggested that the environmental risk factors one of them is chlamydia Pneumoniae may play a role in the initiation of the disease.Objectives:To investigate the relationship between previously Chlamydia Pneumoniae infection and multiple sclerosis disease initiationMethods:Sixty patients with multiple sclerosis (30 newly and 30 previously diagnosed), their ages ranged from 13 to 58 years were enrolled in the present study. They attended seeking for treatment or for the diagnoses of multiple sclerosis in outpatient clinic at the Medical City, Baghdad Teaching Hospital, Baghdad in the period from December 2014 till March 2015. In addition, thirty healthy volunteers their gender and ages were matched with patients group were participated as a control. We measured the anti chlamydia Pneumoniae IgG by ELISA technique.Results:The chlamydia Pneumoniae positivity in the multiple sclerosis patients was considerably higher than the control group but the variation was not significant (p > 0.05) and there was no difference between the previously and newly diagnosed multiple sclerosis patients.Conclusion:There is no statistically significant relationship between previously chlamydia Pneumoniae infection and MS disease.Keywords:Multiple sclerosis, chlamydia Pneumoniae


Article
HLA-DRB ALLELS, IL-10 AND VITAMIN D LEVEL: POTENTIAL IMPACT ON MULTIPLE SCLEROSIS

Authors: Ahmed A.H. Abbas احمد عبد الحسن عباس --- Alaa H. Khaliel علاء حسن خليل --- Nawfal M. Shaheed نوفل ماضي شهيد
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2016 Volume: 14 Issue: 2 Pages: 159-165
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease with unknown etiology. Variation in the HLA-DRB1 gene is the potent genetic risk factor for promoting MS. Other agents relate with an increased risk of developing MS include the cytokines levels such as interleukin-10 (IL-10) and the vitamin D (vit. D) deficiency.Objectives:To study a possible role of HLA-DRB1, vit. D deficiency as a risk factor for MS development and to estimate the level of IL-10 in the serum of MS patients and its role in disease initiation or progression.Methods:Sixty MS patients, of them 30 were newly diagnosed with an age range between 13 and 58 years were included in this study, in addition to thirty healthy volunteers their gender and age matched with patients group serve as a control group. Blood samples collected to assess serum levels of vit. D and IL-10 by Enzyme-Linked Immunosorbant Assay (ELISA) and for DNA extraction, which used in the HLA-DRB1 2 digit genotyping.Results :The HLA-DRB1 genotyping revealed that the HLA-DRB1*15 frequency was higher but statistically insignificant in the MS patients as compared with healthy control group. IL-10 level was significantly lower in MS patients on treatment than the control group. On the other hand, vit. D in the newly diagnosed MS patients was significantly different from the control group (higher in the control group), but there was no variance with MS patients on treatment, the level of vit. D in the studied groups was less than global value.Conclusion:In MS patients the frequency of HLA-DRB1*15 was higher than control group but the difference was not significant. In addition, the level of IL-10 and vit. D may have a role in the development of MS.Keywords:Multiple sclerosis, human leukocyte antigen, IL-10

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