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The Correlation between Lipid Profile and Lipid Peroxidation in Patients with Acute Myocardial Infraction

Authors: Mufeed J. Ewadh مفيد جليل عوض --- Abdulsamie H. Alta'ee عبدالسميع حسن الطائي --- Husain S. Aljanabi --- Alaa Hummady Alta’ee
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2005 Volume: 2 Issue: 3 Pages: 301-306
Publisher: Babylon University جامعة بابل


To measure the association between risk factor of cardiovascular disease (CVD) and lipid peroxidation in patients with acute myocardial infraction (AMI) and healthy controls, twenty six patients (17 males, 9 females) with AMI clinically diagnosed admitted to Merjan Teaching Hospital in Hilla city and fifty two (25 males ,27 females) apparently healthy persons as a controls subject to present study. Determination of serum total cholesterol (TC), triacylglycerol (TG), high density lipoprotein (HDL)-cholesterol, serum glutathione and serum lipid peroxidation were preformed using colorimetric methods. Very low density lipoprotein (VLDL) and low density lipoprotein (LDL) was determined using mathematically method. TC and TG of males with AMI found to be significantly increased and total cholesterol of females with AMI found to be increased when compared with healthy controls. HDL- cholesterol of patients found to be decreased, whereas risk factor was significantly increased. VLDL of patients with AMI found to be significantly decreased, whereas LDL found to be significantly increased. Lipid peroxidation was increased, but serum glutathione was declined significantly in patients with AMI when compared with healthy controls. The correlation between lipid peroxide and TG shows a positive relationship of oxidation product excretion at higher levels of TG. We conclude that patients with elevated levels of serum TG and cholesterol are at increased risk of oxidative damage due to lipid peroxidation.


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