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Bacteriological and immunological study of aggressive periodontitis in Mosul

Authors: Alaa M. Altaei --- Mahmoud Y.M. Taha
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2011 Volume: 11 Issue: 3 Pages: 207-214
Publisher: Mosul University جامعة الموصل

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Abstract

Aims of the study: to isolate and identify microorganisms causing aggressive periodontitis, and to estimate the changes in the levels of IL-1, TNF- and CRP in serum as well as to determine peroxidase activity in saliva of patients with aggressive periodontitis. Materials and Methods: This study was carried out on total number of 40 (35 patients with aggressive periodontitis, 18 females and 17 males aged between 16-35 years and 5 control group between 20-30 years old). Samples were taken from the lesion for bacteriological study. Serum and saliva were collected and ELISA test was performed. Results: The bacteriological results showed that A. actinomycetemcomitans was the most prevalent bacteria in aggressive periodontitis, followed by facultative anaerobic. The serological and biochemical studies showed that interleukin-1 was significantly elevated in the study group while tumor necrosis factor was not, whereas peroxidase enzyme activity and C-reactive protein were also highly significant elevated in the study group. Conclusion: Actinobacillus actinomycetemcomitans was the major etiologic bacteria of this disease as well as significantly high levels of, CRP, peroxidase activity and IL-1 could be regarded as strong markers for more precise understanding the immunological aspect of this disease

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