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Article
Serum Magnesium Concentration in Patients with Leukemia and Lymphoma

Authors: Munaf S. Daoud --- Ali Y. majid** --- Wafa M. Merza
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2009 Volume: 51 Issue: 1 Pages: 101-104
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Leukemias and lymphomas are malignant disorders that occur in the blood forming organs and lymphoid tissue respectively. They are classified to types and several subtypes such as acute or chronic, lymphocytic or myelocytic and T-cell or B-cell lymphocytic for leukemias and histologically into Hodgkin’s and Non-Hodgkin’s for lymphomas. Literatures do not contain many research work on magnesium in patients with these disorders, although this mineral is essential for many metabolic, enzymic, regulatory and immune reactions in the human body. Therefore, the present study was aimed to evaluate the level of magnesium in the sera of patients with different types of leukemia and lymphoma. Patients and Methods: Fifty five patients with leukemia and lymphoma and twenty five healthy controls were studied. The patients were attendants of Baghdad Teaching Hospital and Pediatric Teaching Hospital from September 2006 to January 2007. The diagnosis was confirmed by examination of both peripheral blood, lymph node biopsy and/or bone marrow examination. Patients were categorized according to French-American-British Criteria. Thirty five patients with ALL, one with CLL, six with AML, three with CML, three with HL and seven with NHL. Venous blood was collected from each patient or control person and sera were obtained by centrifugation. S[Mg] was measured by Atomic Absorption Flame Spectrophotometry.Results:The Mean ± SD of S[Mg] in mg/dl of all types of leukemic and lymphomatous patients was lower than the controls. There was a high statistically significant difference (P<0.01) in patients with ALL and significant difference (P<0.05) in patients with AML and NHL and non-significant difference (P>0.05) in patients with CML and HL, compared with the control. Total patients group showed high significant difference (P<0.01) compared with control group. The mean distribution of S[Mg] among total patients indicated decreased (58.2%), normal (38.2%) and increased (3.6%) levels.Conclusion:The present study disclosed the existence of normal to decreased level of S[Mg] in patients with leukemia and lymphoma suggesting an influence of many variable factors. Although the decreased S[Mg] was statistically significant, it was still within lower normal range.


Article
Status of Some Trace Elementsin Idiopathic and Ischemic Cardiomyopathy and Coronary Artery Disease: Echocardiographic Correlation

Authors: Waleed K. Hussein --- Ali Y. Majid --- Basil O. Saleh
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2010 Volume: 52 Issue: 3 Pages: 331-335
Publisher: Baghdad University جامعة بغداد

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Abstract

Background:The most principal mechanisms of cardiomyopathies are;high preload and afterload and low myocardial contractility, imbalance of trace elements may cause myocardial metabolic dysfunction and may have a role in aetiology of cardiomyopathy, particulary in IDC. Trace elements are being increasingly recognized as essential mediators of the development and progression of heart diseases.
Methods: Study design Multi case-control study and single center estimation of trace elements concentrations in a number of volunteer settings this study was conducted in the Department of Cardiology, Ibn Albitar Hospital, and in the Physiological Chemistry Department of the College of Medicine, Baghdad University, from June 2005 to July 2006. Subjects Twenty-five patients with IDC, 15 patients with ICM, 16 patients with coronary artery disease(CAD) who have normal LV function, and seventeen healthy individuals as controls were included in this study. Investigations included serum estimation of zinc (Zn), copper (Cu), and magnesium (Mg) concentrations in these groups of patients and controls.
Results: The mean (±SD) value of serum zinc was significantly decreased in CAD patients compared with controls (P< 0.003). Serum Cu values (mean±SD) were significantly higher in IDC, ICM and CAD groups than in controls (P< 0.0001, P< 0.002, and P< 0.007, respectively). Serum Mg (mean±SD) value was significantly decreased in ICM patients compared to controls (P<0.007). Furthermore, there was a significant positive correlation between serum Mg levels and the values of LVEF % in IDC patients (r=0.522, P< 0.007).
Conclusion: This study confirmed that heart failure (IDC and ICM) and CAD are associated with serum trace elements (Zn, C u, and Mg) abnormalities.


Article
Serum Trace Elements (Zinc, Copper and Magnesium) Status in Iraqi Patients with Acne Vulgaris :( Case- Controlled Study)

Authors: Ali Y. Majid --- Zainab N. H. Anbar --- Basil OM Saleh
Journal: Iraqi Journal of Pharmaceutical Sciences المجلة العراقية للعلوم الصيدلانية ISSN: 16833597 Year: 2011 Volume: 20 Issue: 2 Pages: 44-49
Publisher: Baghdad University جامعة بغداد

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Abstract

Recently on the dermatological fields, the serum levels and the roles of Zn, Cu and Mg have been studied especially in acne vulgaris, but the results were controversial. The aim of the present study is to investigate a relationship between the severity of acne and the serum levels of zinc (Zn), copper (Cu) and magnesium (Mg) and to demonstrate the status of serum levels of zinc, copper, and magnesium in Iraqi male patients with acne vulgaris and to compare it with those of healthy controls.This case controlled study was conducted in the Department of Dermatology and Venerology and in the Poisoning Consultation Center of Baghdad Teaching Hospital between May 2009 to January 2010. Forty- five male patients with acne vulgaris, their ages ranged from 18-30 (21.82±3.77) years and 45 healthy male subjects as controls, their ages ranged from 18-30 (22.18±3.85) years were included in this study. Patients were subdivided into three groups according to the severity of their acne; mild acne group (n=15), moderate (n=15) and severe acne group (n=15). Investigations included serum estimation of Zn, Cu and Mg in both patient and control groups.The data obtained from this study showed that the (mean±SD) values of serum levels of Zn was significantly decreased in severe acne group compared with controls, mild and moderate type of acne group (P< 0.05). Serum Mg concentration was significantly lower in severe acne group compared with mild and moderate acne group (P< 0.05). With regard to serum Cu, there were no significant differences among groups of patients with acne vulgaris.This study revealed a significant association between serum levels of either Zn or Mg with the severity of acne.

أن مستوى وأھمیة الخارصین والنحاس والمغنیسیوم في مصول المرضى المصابین بالأمراض الجلدیة, وخاصة مرض حبالشباب تم دراستھ ولكن النتائج كانت متباینة.أن ھدف ھذه الدراسة ھو تقییم مستوى العناصر المعدنیة(الخارصین, النحاس, المغنیسیوم)في مصول الذكور العراقیین المصابین بمرض حب الشباب والذكور الأصحاء ودراسة العلاقة بین مستوى ھذه العناصر وشدة حبالشباب.لقد تم أجراء ھذه الدراسة في قسم الأمراض الجلدیة و التناسلیة والمركز الاستشاري للسموم في مستشفى بغداد التعلیمي للفترة٤٥ ذكر مصاب بحب الشباب تتراوح أعمارھم بین ( ١8 30 سنة), المعدل . ٢ ولغایة كانون الثاني ٢٠١٠ ٠٠ من أیار ٩٣,٧٧ ) سنة و ٤٥ ذكر صحیح(مجموعة السیطرة) بنفس الفئة العمریة ( 18 30 – ٢ +الانحراف المعیاري لأعمارھم ھو ( ١,٨٢٣,٨٥ سنة) تم شمولھم في ھذه الدراسة. أن مجموعة المرضى تم تقسیمھا - سنة), المعدل +الانحراف المعیاري لأعمارھم ھو( ٢٢,18إلى ثلاث فئات حسب شدة حب الشباب: فئة حب الشباب النوع البسیط وعددھم ١٥ , فئة حب الشباب النوع المتوسط وعددھم ١٥ , فئةحب الشباب النوع الشدید وعددھم ١٣ . الفحوص تشمل تحدید مستوى الخارصین, النحاس, والمغنیسیوم ي في مصول الأشخاصالأصحاء والمرضى. أظھرت نتائج الدراسة عدم وجود فرق إحصائي معنوي في مستوى العناصر(الخارصین, النحاس, المغنیسیوم)بین مجموعتي المرضى والأصحاء. لكن, مستوى الخارصین قد أنخفض بمستوى إحصائي معنوي لدى فئة حب الشباب النوع الشدیدكذلك أظھرت الدراسة انخفاض إحصائي .( P< مقارنة مع مجموعة الأصحاء ومجموعة فئة حب الشباب النوع البسیط( 0.05وفي ما یخص .(P< معنوي في مستوى المغنیسیوم لدى فئة حب الشباب النوع الشدید مقارنة مع فئة حب الشباب النوع البسیط( 0.05مستوى النحاس , لایوجد فرق معنوي بین فئات حب الشباب . یمكن الاستنتاج من ھذه الدراسة بأن ھناك علاقة معنویة بین مستوى كلمن الخارصین والمغنیسیوم في مصول المرضى المصابین بحب الشباب مع شدة المرض.

Keywords

Acne vulgaris --- zinc --- copper --- magnesium


Article
Periodontal health status of heavy and light smokers and its correlation with salivary superoxide dismutase enzyme (A comparative study)

Authors: Banaz J. Ali --- Leka'a M. Ibrahim --- Ali Y. Majid
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2013 Volume: 25 Issue: 3 Pages: 97-102
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Periodontal disease is a chronic bacterial infection that affects the gingiva and bone supporting theteeth. Smoking, which is an important risk factor for periodontitis, induce oxidative stress in the body and cause animbalance between reactive oxygen species (ROS) and antioxidants, such as superoxide dismutase (SOD). This studyaimed to evaluate the influence of smoking on periodontal health status by estimating the levels of salivary SOD levelin non-smokers (controls) and light and heavy smokers and to test the correlation between the SOD enzyme leveland the clinical periodontal parameters in each group.Materials and Methods: The study sample consisted of 75 male, with age ranged from 35 to 50 years. Clinically, theperiodontal parameters used in this study were Plaque index (PLI). Gingival index (GI), probing pocket depth (PPD),Bleeding on probing (BOP) and clinical attachment level (CAL), unstimulated saliva sample were collected from allsubjects and the levels of superoxide dismutase enzyme was analyzed for each group , and correlate the mean ofsalivary enzyme levels with the clinical periodontal parameters.Results: Highly significant differences in PLI between (non smokers/heavy smokers) and (light smokers/heavysmokers).On the other hand no significant difference in gingival index between groups.There were a high association between severity of smoking & probing pocket depth and there is associationbetween severity of smoking and clinical attachment loss. There were a significant difference in the level of salivarysuperoxide dismutase enzyme between the (non smokers/light smokers) groups & between (heavy smokers/lightsmokers) &there were highly significant differences between (non smokers/heavy smokers) groups. There is nocorrelation between the activities of the salivary superoxide dismutase enzyme and the clinical periodontalparameters except in SOD with (BOP score 0 and PPD score 1&score 3) in heavy smokers group.Conclusions: Superoxide dismutase enzyme can be used as biomarker for estimating the level of oxidative stress onsmoking habits.


Article
Evaluation of inorganic ions and enzymes levels in saliva of patients with chronic periodontitis and healthy subjects

Authors: Sameeah I. Khamees سامية خميس --- Ayser N. Mohammad ايسر محمد --- Ali Y. Majid
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2012 Volume: 24 Issue: special issue 2 Pages: 106-111
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Chronic periodontitis is an inflammatory disease of tissues supporting the teeth. Inorganic ions andsalivary enzymes have been most intensely studied as a potential marker for periodontal disease. This study aimed todetect sodium, potassium, magnesium and calcium ions level in saliva & also to assess the activity of creatin kinase(CK) and gamma glutamyle tranferase (GGT) enzymes in saliva of patients with chronic periodontitis and healthysubjects and correlate the mean salivary levels of these ions and enzymes with clinical periodontal parameters (PLI,GI, PPD and CAL).Materials and Methods: The study sample consists of (23) patients with chronic periodontitis and (12) healthy subjectsof both gender with age ranged (35-45) years .Plaque index (PLI). Gingival index (GI), probing pocket depth (PPD)and clinical attachment level (CAL) are the periodontal parameters used in this study, un stimulated saliva samplewere collected from all subjects and the levels of sodium, calcium, Magnesium, potassium, CK and GGT enzymes ineach specimen were analyzed for each group .A statistical analysis was done to estimate the levels of these ionsand enzymes in saliva and correlate the mean salivary inorganic and enzyme levels with the clinical periodontalparameters.Results: The present study showed that highly significant and significant differences in the levels of inorganic ions Na+and Ca+2 respectively was found between chronic periodontitis and control group, while non significant differencesin the level of Mg+2 and K+ ions were found between the study group and control group. Highly significant differencesin the levels of salivary enzymes CK and GGT were found between the control group and chronic periodontitis group.This study showed a positive correlation between the activity CK enzyme and PLI, GI and CAL. Also there was asignificant correlation found between Na+, Ca+2 and CAL. Concerning PPD, there was no correlation between thoseions and enzymes with PPD in chronic periodontitis patients.Conclusion: estimation of those in organic ions and enzymes in saliva of chronic periodontitis may be used aspotential diagnostic markers of disease status in periodontal tissues


Article
Nutritional Status among a Group of Preschool Children in Relation to Concentration of Selected Elements in Saliva and Caries Severity (A Comparative Study)

Authors: Shahba’a Munther شهباء منذر --- Ali Y. Majid علي يحيى ماجد
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2016 Volume: 28 Issue: 1 Pages: 147-152
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Nutritional status during childhood is very important for individual development and growth. Nutritionhas local and systemic effect on the oral health by affecting dental health and salivary composition. This study wasaimed to determine effect of iron, sodium and potassium ions in saliva on the nutritional status and to determine theeffect of nutritional status on caries severity among preschool children.Material and Methods: The sample consists of 90 children aged 4 and 5 years of both genders, selected from 6kindergartens in Al-Resafa aspect of Baghdad province. Children classified according to their nutritional status intothree groups (normalweight, underweight and overweight). Nutritional status was determined by using body massindex BMI that achieved from height and weight (weight (Kg)/height (m)2). Assessment and recording of cariesexperience was done by the application of decayed, missing, filled index (dmfs for primary teeth). The diagnosis ofdental caries was done according to (d1-4 mfs) criteria for primary teeth. Stimulated saliva was collected fromchildren between 9-11 AM under standardized conditions and chemically analyzed to determine the concentrationof iron, sodium and potassium calorimetrically by using ready-made kits and spectrophotometer machine. Datawere analyzed using SPSS version 19.Results: Concentration of sodium, potassium and iron ions were (46.64 mg/dl ± 18.00, 31.22 mg/dl ± 9.84, 17.76μg/dl ±3.17) respectively. From the elements measured in saliva only sodium ions recorded statistically significant differenceamong the three groups of nutritional status. By application of LSD, the significant difference was found to bebetween normal weight and overweight groups (46.33 mg/dl ± 17.18, 40.64 mg/dl ± 14.79) respectively (P<0.05).Furthermore, positive and statistically significant correlations were recorded between sodium ions with BMI mean ofoverweight group on one hand (r=- 0.125, P<0.05) and iron ions and normal weight group on other hand (r=0.362,P<0.05). Recording and diagnosis of dental caries showed that means of ds, ms, dmfs, d2s and d4s were significantlyhigher among children aged 5 years than those aged 4 years. In addition to that means of ds, ms, dmfs and d2s weresignificantly differ among the three groups of nutrition. Application of LSD test showed that those means were higheramong underweight group than others.Conclusion: Concentration of sodium ions in saliva changed according to nutritional status. On the other handnutritional status may affect caries severity, where underweight children suffering from dental caries more thannormalweight and overweight children.


Article
Ovulation detection through salivary levels of sialic acid and glycosaminoglycans

Authors: Rand M. Al-khafagy رند الخفاجي --- Sahar H. Al-Ani سحر العاني --- Ali Y.Majid علي ماجد
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2012 Volume: 24 Issue: 2 Pages: 66-69
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: One in ten couples of reproductive age encounter some level of infertility. Identification of the periodof ovulation in humans is critical in the treatment of infertility. Success in in vitro fertilization and embryo transfer hasbeen associated with the exact time of ovulation. Saliva is a unique diagnostic fluid, the composition of whichimmediately reflects the sympathetic nervous system, parasympathetic nervous system, hypothalamic- pitutaryadrenalaxis and immune system response to stress. The study aims at evaluating the changes in salivary sialic acidand Glycosaminoglycans in the regular menstrual cycle. Thus, the presence of these carbohydrates in the ovulatorysaliva makes the possibility to develop a biomarker for the detection of ovulation by noninvasive methods.Subjects, materials and methods: Randomly, seventy five volunteer females were recruited and divided into 5groups; each contains 15 subjects as follow: Nine years old females and postmenopausal females as control groups,pre-ovulatory period, ovulatory period and post-ovulatory period females as experimental groups. Each female, ofthe experimental groups, underwent sonographic examination to estimate her period regarding ovulation.Unstimulated whole saliva was collected using the spitting method. Colorimetric procedure was used for total sialicacid determination and for Glycosaminoglycans quantitative determination, the method of ELISA was used.Results: The concentration of sialic acid was significantly decreased in saliva of females in the ovulatory phase of themenstrual cycle; whereas, a significant increase in salivary sialic acid concentration was in the post-ovulatory phase.Glycosaminoglycan concentration showed a gradual increase from the pre-ovulatory phase then ovulatory to reachits maximum in the post-ovulatory phase with a significant difference between the pre-ovulatory and post-ovulatoryphases. A significant correlation was not found between sialic acid and Glycosaminoglycans in different studygroups.Conclusions: On the basis of the results arrived at, the study concluded that there are remarkable cyclic variations insialic acid and glycosaminoglycans during the menstrual cycle but in conclusion, glycosaminoglycans and sialicacid salivary levels cannot be used for the precise prediction of ovulation


Article
Concentrations of selected elements in saliva among a group of adolescent girls in relation to severity of caries and selected salivary parameters

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Abstract

Background: Saliva is one of the most important etiological host factors in relation to dental caries. It affects thecarious process by its organic and inorganic constituents; in addition to its physiological functions as (flow rate, pHand buffer capacity). The aims of this study were to determine the concentrations of major elements (calcium andphosphorus) and trace elements (ferrous iron, nickel, chromium and aluminum) in saliva among a group ofadolescent girls, and to explore the relation of these elements, flow rate and pH with dental caries.Material & Methods: The study group consisted of 25 girls with an age of 13-15 years old. Dental caries was diagnosedby both clinical and radiographical examinations following the criteria of D1-4MFS index. Stimulated saliva wascollected from patients between 9-11 Am under standarized conditions, and chemically analyzed to determine theconcentration of calcium, nickel, chromium and aluminum by Atomic Absorption Spectrophotometer, while salivaryphosphorus and ferrous iron were determined by using colorimetric method. The average salivary flow rate wasmeasured from total volume, and salivary pH was determined using digital pH meter. All data were analyzed usingSPSS version 19.Results: All elements measured in saliva in addition to P/Ca ratio recorded statistically non significant correlation withDMFS, except ferrous Fe ions which showed statistically significant correlation (r= 0.34, P=0.05). Salivary flow rate andpH correlated weakly and statistically not significant with DMFSThere were weak and statistically not significant correlations between all elements measured in saliva and salivaryflow rate and pH.Conclusions: It had been found that Fe, Ni, Al and Cr ions present in very small amounts in saliva in comparison to Caand P ions. The presence of these elements in saliva may indicate their presence in food, water and air


Article
Nutritional Status Effect on Gingival Health Condition in Relation to some Salivary Elements among Fifteen-years Old Adolescents
تأثير التغذية على حالة اللثة وعلاقته ببعض عناصر اللعاب لطلاب المدارس بعمر 15 سنة

Authors: Zaid S. Hasan م م د. زيد سعدي حسن --- Ban S. Diab أ م د. بان صاحب ذياب --- Ali Y. Majid استشاري د. علي يعقوب الربيعي
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2013 Volume: 26 Issue: 3 Pages: 225-228
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Abstract:Background: Malnutrition in human life may adversely affect various aspects of growth and increase the severity of oral health problems. This study was conducted among malnourished adolescents aged 15 years in comparison to well-nourished group to determine gingival condition in relation to salivary zinc, magnesium, sodium and potassium.Material and methods: The sample of the present study included 89 malnourished and 95 well-nourished students aged 15 years. The body mass index was used to determine the nutritional status. Diagnosis of dental plaque and gingival health condition were recorded through the application of plaque index and gingival index. The stimulated saliva was collected to determine salivary zinc, magnesium, sodium and potassium.Results: The mean plaque and gingival index value among malnourished were lower than those of well-nourished groups, with no significant difference [P > 0.05] and significant difference [P < 0.05] respectively. The mean values of all inorganic salivary elements were lower among malnourished group than well-nourished group with highly significant difference [P<0.01]. No significant correlation was recorded between gingival index and all salivary elements in malnourished group; whereas a positive statistically significant correlation was indicated for salivary zinc in well-nourished group.Conclusion: Malnutrition affect on lower gingivitis and reducing salivary zinc, magnesium, sodium and potassium.Keywords: Malnutrition, dental plaque, gingival health, stimulated salivary element.

الخلاصة:اساس البحث : سوء التغذية في حياة الانسان قد يؤثر عكسيا ًعلى مختلف اوجه النمو وكذلك زيادة شدة مشاكل الفم في مختلف المراحل في الحياة.الهدف : الدراسة أجريت لمجموعة من سيئي التغذية بالمقارنة مع مجموعة جيدي التغذية لعمر 15 سنه لتحديد حالة اللثة وبعض العناصر (النحاس, المغنيسيوم, الصوديوم, البوتاسيوم).الطرق: هذة الدراسة اجريت لمجموعة سيئي التغذية بالمقارنة مع جيدي التغذية. هذه الدراسة شملت 184 طالب بعمر 15 سنة (89 سيئي التغذية و 95 جيدي التغذية ). تقيم الحالة الغذائية أنجز من خلال استعمال مؤشر كتلة الجسم. فحص مؤشر دليل اللويحات الجرثومية وتم استعمال مؤشر اللثة لقياس صحة اللثة.اللعاب المحفز تم جمعه لتحديد سرعة جريان اللعاب والاس الهيدروجيني وكذلك مكونات اللعاب التي تشمل النحاس, المغنيسيوم و الصوديوم تم تحليلها بالاضافة الى البوتاسيوم.النتائج: اظهرت النتائج ان وسيط الصفيحة الجرثوميه و التهاب اللثة كان اقل في الاشخاص سيئي التغذيةعنه في جيدي التغذية مع عدم وجود فارق معنوي ووجود فارق معنوي بين المجموعتين تباعا ً. كان وسيط جميع عناصر اللعاب اقل في الاشخاص سيئي التغذيةعنه في جيدي التغذية مع عدم وجود فارق معنوي عالي بين المجموعتين. لاتوجد علاقة بين التهاب اللثة و جميع عناصر اللعاب المحفز في مجمعة جيدي التغذية بينما العلاقة ايجابية وبفرق معنوي فيما يخص النحاس في مجموعة جيدي التغذية. الاستنتاجات: سوء التغذية يؤدي الى تقليل التهاب اللثة وكذلك مكونات اللعاب التي تشمل النحاس, المغنيسيوم و الصوديوم تم تحليلها بالاضافة الى البوتاسيوم الكلمات المفتاحية: سوء التغذية, التهاب اللثة, عناصر اللعاب المحفز


Article
Evaluation of serum levels Superoxide dismutase in women with polycystic ovarian syndrome and gingivitis

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Abstract

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality in women, there is an increasing evidence for an oxidative stress in PCOS that induce genomic and mitochondrial deoxyribonucleic acid damage that leads directly to reduced fertility. The objectives of this study are to assess and compare the periodontal health status by measuring clinical periodontal parameters (PLI, GI and BOP)as well as serum levels of superoxide dismutase at gingivitis ,gingivitis with PCOS and healthy periodontium groups, then correlate between clinical and biochemical parameters.Materials and Methods: 60 females with an age range between (25-40) years old had been tested and divided into3 groups ,the control group consists of (20) females with healthy periodontium, group of (20) females with gingivitis and group of (20) females with gingivitis and PCOS. After completion of clinical periodontal parameters recording (PLI, GI& BOP), blood samples were collected and biochemical analysis of serum samples were carried out by using [Super oxide dismutase Assay kit] to evaluate serum super oxide dismutase levels.Results: The highest mean values of PLI,GI and BOP score1 were found in gingivitis+PCOS group. Highly significant difference was revealed among the groups regarding mean values of Superoxide dismutase with the highest mean value at gingivitis+ PCOS followed by gingivitis groups. Non-significant correlation were demonstrated between clinical and biochemical parameters except the significant moderate positive correlation of BOP at gingivitis+PCOS group.Conclusion: It could be certified that severity of gingivitis may increase in patients with PCOS. The concentration of serum SOD increased with the severity of gingival inflammation as well as the presence of PCOS. Serum SOD may be useful biochemical marker for early detection of periodontal disease and PCOS

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