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Article
The Effect of Long Term use of Glibenclamide on Serum and Urinary Sodium and Potassium Level in Type 2 DM Patients
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Author: Ali A. Ali علي عزيز علي
Journal: Iraqi Journal of Pharmaceutical Sciences المجلة العراقية للعلوم الصيدلانية ISSN: 16833597 Year: 2010 Volume: 19 Issue: 1 Pages: 58-61
Publisher: Baghdad University جامعة بغداد

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Abstract

Long-term use of sulfonylureas including chlorpropamide, is known to potentiate the antidiuretic action of arginine vasopressin (AVP), predisposing to hyponatremia.The present study was designed to evaluate the effect of long term use of glibenclamide on serum and urinary levels of sodium and potassium in Type 2 DM patients in Iraqi DM centers. Ninety eight patients with Type 2 DM who were maintained on different doses of glibenclamide for at least 1 year, attending the centre for Diabetes and Endocrinology in Al-Rusafa, Baghdad, were enrolled in the study, in addition to 15 normal healthy subjects. Patients were allocated into three groups according to the dose of glibenclamide that they received. Blood and urine samples were obtained for evaluation of sodium and potassium levels in these samples by flamephotometry. The results indicated that glibenclamide use resulted in significant elevation in serum levels of sodium and potassium compared to controls, while urinary excretion of these cations was not significantly changed. Stratification of patients according to the dose of glibenclamide revealed that this effect on sodium and potassium was not dose dependent. In conclusion, long term use of glibenclamide impairs normal values of Sodium and potassium independent of the administered dose.

ان دواء الكلوربروبامايد وهو من مجموعة السلفونيل يوريا يستخدم لعلاج مرضى السكري من النوع الثاني ( غير المعتمد على الانسولين) وهو معروف بتحفيزه لعمل الهرمون المضاد للبول والذي يسبب نقص الصوديوم و يعتقد ان هذا الدواء يعمل مباشرة على مستقبلات هرمون المضاد للبول. في هذا البحث نود دراسة تاثير دواء الكليبينكلامايد وهو من نفس مجموعة الكلوربروبامايد (أي السلفونيل يوريا)على تركيز الصوديوم والبوتاسيوم في الدم (المصل) وكذلك في البول المجموع خلال 24 ساعة في المرضى المصابين بداء السكري النوع الثاني وقد اجريت هذا الدراسة في شهر ايلول2008 ولغاية شهر كانون الثاني من عام2009 وقد شارك في هذه الدراسة 98 مريض خارجي من مركز الغدد الصم والسكري في الرصافة ببغداد بالتعاون مع الطبيب الاستشاري هناك و 15 شخص سليم وقد اخذت عينات من المصل والبول (البول المجموع خلال 24 ساعة في المنزل)وقد تم قياس تركيز الصوديوم والبوتاسيوم بواسطة جهاز قياس الالوان في اللهب واظهرت النتائج ان الكليبينكلامايد يؤثر بشكل ملحوظ على تركيز الصوديوم والبوتاسيوم في مصل الدم مقارنة مع المجموعة القياسية اما تاثيره على تركيز الصوديوم والبوتاسيم في البول المجموع خلال 24 ساعة لم يكن بشكل ملحوظ.

Keywords

Glibenclamide --- sodium --- potassium


Article
The Wiener Polynomial of The Tensor Product
متعددة حدود وينر للجداء التنسري

Authors: Walid. A. Saeed وليد سعيد --- Ali. A. Ali علي عزيز علي
Journal: Rafidain journal of science مجلة علوم الرافدين ISSN: 16089391 Year: 2006 Volume: 17 Issue: 1E Pages: 67 -77
Publisher: Mosul University جامعة الموصل

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Abstract

Let G1 and G2 be vertex disjoint connected graphs such that each edge of G1 and G2 is a triangle edge. In this paper, the coefficients of the Wiener polynomial of the tensor product G1G2 are determined in terms of the coefficients of W(G1;x) and W(G2;x). The Wiener polynomial of the tensor product of a path graph and an odd cycle graph is also obtained.

ليكن G1و G2 بيانين متصلين وليس بينهما رأس مشترك وان كل حافة فيهما تقع في مثلث. تم في هذا البحث تحديد معاملات متعددة حدود وينر للجداء التنسري G1G2 بدلالة معاملات متعد دتي حدود وينر W(G1;x) و W(G2;x). وايضا تضمن البحث ايجاد متعددة حدود وينر للجداء التنسري لبيان درب مع بيان دارة فردية.

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Article
The Chages in Sex Hormones in Female Working in Battries Manufacturing Plant

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Abstract

Lead has toxic effects on reproduction of both male and female. It can cause decreased sex drive , infertility and abnormal menstrual cycle in women. This study was designed to evaluate the effect of exposure to lead in batteries female workers on sex hormones level in the serum.Thirty nine (39) female workers (volunteers) in Iraqi Batteries Manufacturing Plants, Al-Waziriya / Baghdad were participated in this study. They are classified into 3 groups, first group included fourteen (14) female that have been employed for 1-7 years , second group included thirteen (13) female that have been employed for 8-14 years , third group included twelve (12) female have been employed for15-22 years and and fourteen females were included as the control . Blood lead level, serum FSH, LH, prolactin and total testosterone were measured and compared for all subjects.The results indicated that mean of blood lead levels (BLL), testosterone levels were highly significant in all worker groups compared to the control (p<0.005).Prolactin levels in group I and FSH in group III were significantly higher than that in control ( P< 0.005) and (P<0.05) respectively. LH levels in groups II and III were significantly higher than that in control (P<0.05, P<0.005 respectively). High incidence of hirsutism (48%) and miscarriages (50%) were observed in worker groups compared to control (11%). The results indicated that there are hormonal changes in female workers exposed to lead associated with increased incidence of hirsutism and miscarriages compared to non exposed females .

تسعة وثلاثون امرأة عاملة في معمل صناعة البطاريات في بغداد شاركن في هذه الدراسة كمتطوعات قسمت العاملات الى ثلاث مجاميع اعتمادا على فترة التعرض للرصاص.١-المجموعة الأولى تشمل (١٤) عاملة وفترة الخدمة تتراوح بين (١ـ٧) سنوات وبعمر (٢٤ـ٥٠) سنة.٢ـ المجموعة الثانية تشمل (١٣) عاملة وفترة الخدمة تتراوح بين (٨ـ١٤) سنة وبعمر (٣٠ـ٥٥) سنة ٣ـ المجموعة الثتلثة تشمل (١٢) عاملة وفترة الخدمة تتراوح بين (١٥ـ٢٢) سنة وبعمر (٣٢ـ٥٢) سنة.٤-المجموعة الرابعة: مجموعة السيطرة وتشمل (١٤) امرأة بمتوسط عمر( ٢٩±١.٧) سنة.وجد في هذه الدراسة ان هنالك تغير في مستوى الهرمونات الجنسية عند النساء العاملات عند مقارنتها بمجموعة السيطرة.وجد كذلك ان مستوى الهورمون اللوتيني في المصل يزداد عند العاملات اللواتي تعرضن للرصاص لفترة طويلة اما هورمون محفز الجريب في المصل يزداد فقط عند النعرض لفترة طويلة.اما هورمون (البرولاكتين ) فيزداد فقط بعد التعرض لفترة قصيرة للرصاص.كذلك هورمون التيستوستيرون الكلي يزداد عند النساء العاملات متصاحبا مع زيادة في نسبة الشعرانية والاسقاطات عند العاملات مقارنة بمجموعة السيطرة.


Article
OPEN VERSUS CLOSED METHODS IN TREATMENT OF PILONIDAL SINUS DISEASE

Authors: Ali A Ali علي عزيز علي --- Basher A Abdul-Hassan بشار عباس عبد الحسن --- Anees K. Nile انيس خليل نايل
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2011 Volume: 9 Issue: 2 Pages: 114-119
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background: Pilonidal sinus disease can be managed surgically either by excision & primary closure, or by excision and leaving the wound to heal by secondary intention. This study is designed to show the difference between these two methods.Objective: To assess the difference between excision and primary closure versus excision and healing by secondary intention in treatment of pilonidal sinus disease.Methods: Between January 2005 and January 2009, 60 median aged patients with Pilonidal sinus disease were studied in Al-Kadhimiya Teaching Hospital, Baghdad, Iraq; 30 cases were operated by excision and primary closure (group І); the remaining 30 cases were operated by excision and healing by secondary intention, without closure (group II). The principle outcome measures recorded were duration of hospital stay, operative time, duration of complete healing, wound infection and recurrence rate. Satisfaction and comfort of patient was monitored by using visual analogue scale during first five days post-operatively. Data were statistically analyzed by using SPSS & Chi square.Results: A total of 60 patients were divided into 2 groups, 30 patients operated by using primary closure (group I), and 30 patients operated without closure (group II). Age range of patients was from (16 - 37 yrs). Duration of hospital stay and duration of complete healing was longer in patients of group II than those of group I (p ≤ 0.001). Operative time in group I is more than that in group II (p ≤ 0.001). Pain scores were lower in group I than group II (p = 0.004). The frequency of wound infection and recurrence rate after one year follow up were more in group I than group II, this was statistically of little significance.Conclusions: Excision and primary closure is recommended as a preferred procedure in the management of chronic sacral PNS disease. It has the advantages of short hospital stay, early wound healing, rapid return to work.Key words:pilonidal sinus, primary closure, secondary intention

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