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Article
Postmenopausal Bleeding: Clinical Significance and Histopathological Evaluation

Author: Ali H. Al-Timimi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2004 Volume: 1 Issue: 3-4 Pages: 240-252
Publisher: Babylon University جامعة بابل

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Abstract

Normal menstruation is defined as the bleeding from secretory endometrium associated with an ovulatory cycle not exceeding a length of 5 days. Any bleeding not fulfilling these criteria is referred to as an abnormal uterine bleeding. Some of these are the result of an identifiable pathological lesion, such as endometriosis, submucous myoma, endometrial polyp, or cancer, particularly in the postmenopausal patient. The aim of the present study was to investigate the clinical significance and endometrial pathology in patients with postmenopausal bleeding (PMB) in terms of etiology, risks factors, incidence of malignancy, and histopathological evaluation. 202 cases of PMB admitted to Basrah Maternity Teaching Hospital from 1990-1999 underwent a detailed history, clinical examination and full investigation, including full laboratory investigation, pelvic ultrasound, and examination under anesthesia (EUA) with dilatation and curettage and tissue sampling. The age range of the patient was from (35 to 72 years) with a mean of (49 years). The Results showed that Benign pathology was found in (184 / 209) cases. These included senile atrophic endometrium, normal functioning endometrium, endometrial hyperplasia, endometritis, polyps, cervicitis, and cervical polyps. Malignant pathology was found in (18) cases including (8) cases of cancer of the cervix and (10) cases of adenocarcinoma of the endometrium. It is concluded that postmenopausal bleeding is an important symptom and requires careful and prompt evaluation to eliminate the possibility of malignancy as quickly as possible.

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Article
Study of Membrane Testosterone Receptors in Prostate Cancer

Authors: Ali H.AL-Timimi --- Emad Hassan Mahmood
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2007 Volume: 4 Issue: 1-2 Pages: 60-72
Publisher: Babylon University جامعة بابل

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Abstract

Prostate cancer is one of the most frequent malignancies in males. Recently, the identification of a membrane testosterone binding site involved in the remodeling of actin cytoskeleton structures and PSA secretion, on human prostate cancer cells has been reported. We have investigated whether this membrane testosterone binding component could be of value for the identification of prostate cancer. We have investigated the expression of membrane testosterone binding sites in a series of prostate carcinomas (n = 15), morphologically normal epithelia, taken from areas of the surgical specimens far from the location of the carcinomas (n = 10) and benign prostate hyperplasia epithelia (n = 10). Isolated epithelial cells were studied by immunohistochemistry, and touching preparations, after 10-min incubation. In addition, routine histological slides were assayed. The results showed that membrane testosterone binding sites are preferentially expressed in prostate carcinoma cells, while BPH and non-malignant epithelial cells showed a low or absent binding. It is concluded that membrane testosterone receptors might be of use for the rapid routine identification of prostate cancer, representing a diagnostic marker of the disease.

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Article
Mucoepidermoid Carcinoma of Salivary Gland Origin: Study of Clinico Pathological features and prognosis

Authors: Ali H.AL-Timimi --- Ali.AL- Katib
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2005 Volume: 2 Issue: 3 Pages: 272-282
Publisher: Babylon University جامعة بابل

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Abstract

Most cases of mucoepidermoid carcinoma are located in the parotid gland. This lesion represents one of the most common malignant salivary gland tumor .We have studied 54 cases of mucoepidermoid carcinoma (MEC) originating in major and minor salivary glands that were admitted to Hilla Teaching Hospitals ,the Department of Surgery, Medical collage, between 1991 and 2003. Following the methods of Auclair and Goode, a quantitative grading system was used. The relationships between clinical and pathologic characteristics and survival rate were investigated. The results revealed that 13(44%) cases located in MASG and 10 (39%) cases in MISG were categorized as high-grade tumors. In patients with MASG tumors, the 5-year disease-free survival rate was 22.5% when the tumor was high grade and 97.0% if the tumor was low grade (P < .0001). For patients with a tumor of the MISG, the percentages were 35.3% for high-grade and 80.0% for low-grade tumors (P = .0066). Our conclusions confirms that in mucoepidermoid carcinoma, tumor grade, subdividing cases into low and high grade by using the criteria delineated by Auclair and Goode, correlates well with prognosis.

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Article
ProphylacticAppendicectomyDuringElectiveCholecystectomy: Effects on Morbidity. A Prospective Controlled Study

Authors: Ali A. Al-katib --- Ali. H. Al-Timimi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2005 Volume: 2 Issue: 3 Pages: 336-341
Publisher: Babylon University جامعة بابل

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Abstract

Prophylactic appendicectomy was performed on 56 consenting patients undergoing elective cholecystectomy in hilla surgecal hospitals. The control group consisted of 60 patients. Both groups were well matched in respect of age, sex, & type of incision. All patients received a single i.v. dose of 1g Cefazolin sodium and 500mg Metronidazole at induction of anaesthesia. Postoperative wound sepsis occurred in (3 patients) 5.4% of the appendicectomy group and in (4 patients) 6.7% of the control group. Residual intra-abdominal sepsis did not occur in either group. The mean duration of postoperative hospital stay was 6.1 days(SD= 1.63) in the appendicectomy group and 5.5 days(SD=1.85) in the control group. These differences were not statistically significant. Six(10.7%) of the appendices removed were abnormal, including two with inflammation. The conclusion of this study is that prophylactic appendicectomy can be performed safely during elective cholecystectomy provided that it is done without undue manipulation & the patient is protected with an effective prophylactic antibiotic regimen.

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Article
Schistosomial Infestation and Histopathplogical Features to Patients Diagnosed as Acute Appendicitis

Authors: Ali A. Al-Katib*; --- Mohend A. N. Al-Shalah --- Ali H. Al-Timimi
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2010 Volume: 3 no.3, 4 Issue: 7 Pages: 910-913
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: Schistosomial infestation is commonly infested the appendix. However itis not known if this- is a predisposing, factor for appendicitis, or a mere coincidentalhistological finding.Patients and methods: In the present study a total of 48 cases (40 males and 8 females)underwent appendectomy for schistosomal appendicitis over a 10-year period at Basrah andHilla Teaching hospitals were studied. Their histological slides were reviewed carefully.Results: showed that the highest incidence of schistosomal appendicitis was recorded in the21-40-year age group. Ova were seen in the submucosal layers of all the excised appendices.The most common tissue responses were submucosal fibrosis (93.8%) and eosinophilia(89.6%), followed by the presence of suppurative inflammation (75%). Granulomatousreaction was evident in 32 cases (66.6%),and commonly found in the serosa and submucosa.A feature of atrophy of submucosal lymphoid follicles was noted in 48% of the cases andhyperplasia in 44%. most.. Similar tissue responses were histologically seen in three normalappendices examined.Conclusion: Appendiceal infestation may predispose to appendicitis in the majority ofaffected cases, but in others, it may well be a mere coincidental histological finding.However, preoperative knowledge bears no Clinical significance and does not altermanagement.

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Article
Breast Cancers: Young Age the Significant Predictor……………..…………….…..

Authors: Ali A.Al-Katib --- Mohend.A.N.Al-Shalah --- Ali H.AL-Timimi
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2011 Volume: 4 no 1 Issue: 9 Pages: 950-956
Publisher: Kerbala University جامعة كربلاء

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Abstract

Background: The incidence of breast cancer in young women (age < 35) is low. The biology of the disease in this age group is poorly understood, and there are conflicting data regarding, the prognosis for these women compared to older patients.Patients and methods: We retrospectively analyzed consecutive primary invasive breast cancer patients who underwent surgical procedures at our institution between 1990 and 2002. The younger age group was defined as patients aged <35 years at the time of diagnosis, the clinicopathological characteristics and treatment outcomes were compared between younger and older age groups.Result: A total of 51 (12.5%) patients were aged <35. There was a significantly higher incidence of nuclear grade 3 and medullary histological-type tumors in younger patients compared to older patients. Axillary lymph node status, T stage, histological grade, and estrogen receptor status did not differ significantly between the two age groups. Younger patients had a greater probability of recurrence and death at all time periods, although there was no significant difference in disease-free survival between the two age groups.In lymph node-negative patients, the younger group showed worse prognosis among lymph node-positive patients (p<0.001).Conclusion: In multivariate analysis, young age remained a significant predictor of recurrence (p=0.010). Young age (<35) is an independent risk factor for relapse in operable breast cancer patients.

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