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Article
Immunohistochemical Study of Disrupted Breast Myoepithelial Cell: Implications for Tumor Metastasis

Author: Ali Hassan Al-Timimi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2007 Volume: 4 Issue: 1-2 Pages: 24-35
Publisher: Babylon University جامعة بابل

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Abstract

Previous studies detected focal disruptions in myoepithelial cell layers of several ducts with carcinoma in situ of breast. The cell cluster overlying each of the myoepithelial disruptions showed a marked reduction in or a total loss of immunoreactivity for the estrogen receptor (ER). This is in contrast to the adjacent cells within the same duct, which were strongly immunoreactive for the ER. Paraffin sections from 55 patients with ER-positive intraductal breast tumors were double immunostained in the current study. Cross-sections of ducts lined by ≥ 40 epithelial cells were examined for myoepithelial cell layer disruptions and for ER expression. Of the 55 cases with 1424 duct cross-sections examined, 24 showed disrupted myoepithelial cell layers with 101 focal disruptions. Of the 24 cases, 20 (84%) contained only ER-negative cell clusters, two (8 %) contained both ER-negative and ER-positive cell clusters, and two (8 %) contained only ER-positive cell clusters overlying disrupted myoepithelial cell layers. Of the 101 disruptions, 88 (87%) were overlain by ER-negative cell clusters and 13(12.8 %) were overlain by ER-positive cell clusters (P < 0.01). It is concluded that cells overlying focally disrupted myoepithelial layers and their adjacent counterparts within the same duct displayed different immunohistochemical and molecular features. These features potentially represent an early sign of the formation of a biologically more aggressive cell clone and the myoepithelial cell layer breakdown possibly associated with tumor progression or invasion.

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Article
Tumor suppressor gene( E-cadherin )and its role in normal and Malignant cells (Part Two)

Author: Ali Hassan AL-Timimi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2005 Volume: 2 Issue: 1 Pages: VIII-XII
Publisher: Babylon University جامعة بابل

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Abstract

Progressive accumulation of somatic mutations in a number of different genes characterizes the process of tumorigenesis. Many genes involved in the process of tumorigenesis are components of one of a great many signal transduction pathways through which signals traffic via molecular networks. It is now apparent that epithelial malignancy can in certain aspects be explained by alterations in the adhesive properties of neoplastic cells.

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Article
Study of Cytokeratins Markers in Breast Carcinomas

Author: Ali Hassan AL–Timimi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2005 Volume: 2 Issue: 1 Pages: 105-113
Publisher: Babylon University جامعة بابل

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Abstract

While several prognostic factors have been identified in breast carcinoma, the clinical outcome remains hard to predict for individual patients. Better predictive markers are needed to help guide difficult treatment decisions. In previous studies of breast carcinoma specimens, an association between poor clinical outcome and the expression of cytokeratin markers 17 and/or cytokeratin 5 mRNAs was noted. Here we describe the results of immunohistochemistry studies using monoclonal antibodies against these markers to analyze 55 paraffin-embedded breast tumors. We found that expression of cytokeratin markers 17 and/or cytokeratin 5/6 in tumor cells was associated with a poor clinical outcome. Moreover, multivariate analysis showed that in node-negative breast carcinoma, expression of these cytokeratins markers were a prognostic factors independent of tumor size and tumor grade.

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Article
Tumor Suppressor Gene( E-Cadherin )and Its Role in Normal and Malignant Cells

Author: Ali Hassan Al-Timimi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2004 Volume: 1 Issue: 3-4 Pages: i-xiii
Publisher: Babylon University جامعة بابل

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Abstract

Tumor suppressor genes (E-cadherin) are particularly active area of research in development and tumorigenesis. The calcium-dependent interactions among E-cadherin molecules are critical for the formation and maintenance of adherent junctions in areas of epithelial cell-cell contact. Loss of E-cadherin-mediated-adhesion characterises the transition from benign lesions to invasive, metastatic cancer. Nevertheless, there is evidence that E-cadherins may also play a role in the wnt signal transduction pathway, together with other key molecules involved in it, such as beta-catenins and adenomatous poliposis coli gene products. The structure and function of E-cadherin, gene and protein, in normal as well as in tumor cells are reviewed in this paper.

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Article
Evaluation of Abnormal Cervical Cytology

Author: Ali Hassan Al-Timimi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2004 Volume: 1 Issue: 2 Pages: 117-123
Publisher: Babylon University جامعة بابل

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Abstract

The indicated clinicat evaluation of ar)?ical squamous cells demonstrated on papanicolaou(Pap) smear has been determined. Although several repons and opinions suggest that these cells arc ofno particular significances, other studies have noted these cetls in instances of advanceal cervicaldysplasia.The Objective of the present srudy was to determine rhe prevalence of dysptasia in106 patients withrecent Pap smear demonstrating atypical squamoxs cell . the study was conducted during the period1998-2002 in the cyne€ologic Clinic at Hilla Hospitals and Deparrnent of parhotogy, BabylonUniversity, Babylon, IRAQ.Abnomal colposopy was present in 59 (55%).ln 21 (36%) ofrhe 59 parienrs, dysplasia was confirmedhistologically. Statistical significance was presenr in each ofthe groups lvith tissue sampling (arypicaland immaturc squamous metaplasia, koilocltoric aq,pia, and dysplasia) when ages were comparedwith the palients having nomal colposcopy. . Pap smear is a significant indicalor of ceryical pathology.Altholgh this Pap smear may not be rsgarded as dysplasia" neither shouid be ignored. Cotposcopy Jndbiopsy of any abnonmlity is recommended in all these patients. Two distinct pattems of initialcletection of cenical dysplasia were apparent.It is concluded that the atpical squamous cell Pap smear is a significant jnd;cator oi.cervicalpathology. Although this atpical Pap smear may not be regarded as dysplasia, neither shoutd beignored. Colposcopy and biopsy of any abnomaliry is recommended in atl tbese patients

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Article
Study of .Focal Arteritis of the Epididymis

Author: Ali Hassan Al-Timimi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2004 Volume: 1 Issue: 2 Pages: 207-211
Publisher: Babylon University جامعة بابل

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Abstract

Necrotising ateritis apparently confined to ono organ yet showing histological fearures similarto those seen in polyarteritis nodosa is now well recognised.To report foxl cases of apparently isolated arteritis ofthe epididymis in patients who have noclinical evidence of systemic disease.The clinical. Histological, and immunohistochemical features of foxl cases of appareltlyisolated arthdtis of the epidilmis are presented. The aetiology and pathogenesis of the conditton arediscussed. Immunoglobulin and complement w€re shown in in acute arlerial lesions, but this is notconclusive evidence that isolatated arteritis is eilher an immune compiex disease or a forme liuste ofpolyarteritis nodosa,It is impodant that any patients with histological evidence of necrotizing aferitis should havefull clinical, hematological, and biochemical investigations to exclude systemic disease because oftheclinical differences between polyartedtis nodosa and isolated arteritis

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Article
Immunohistochemical Detection of MDA –DNA Adducts in Oral Mucosa of Smokers and Nonsmokers

Authors: Ali Hassan AL–Timimi --- Raad Ali Jassim
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2005 Volume: 2 Issue: 2 Pages: 150-157
Publisher: Babylon University جامعة بابل

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Abstract

Malondialdehyde (MDA) is a major lipid peroxidation product that is mutagenic and tumorigenic. MDA-modified DNA adducts have been detected in animal and human tissues and may be a marker of human cancer risk. An immunohistochemical method, using a previously generated monoclonal antibody specific for MDA–DNA adducts, has been developed for the detection and quantification of DNA damage in human oral mucosa cells. The method was used initially on mice liver cells treated with and without MDA, and then applied to the detection of adducts in oral mucosa cells of smokers and non-smokers. Levels of DNA damage were elevated in 25 smokers (mean relative staining intensity 97 ± 41) compared with 25 age-, and sex-matched non-smokers (74 ± 17, P < 0.02). These results demonstrate that MDA–DNA adducts can be measured in single cells of human samples by an immunohistochemical method. This methodology provides a simple way to monitor MDA–DNA damage and should be useful for studies investigating the role of exogenous and endogenous agents in oxidative stress and carcinogenesis.

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Article
Laryngeal Carcinoma: Prognostic Index and Evaluation of Treatment Results

Authors: Ali Hassan Al-Timimi --- Safa Sahib Naji
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2006 Volume: 3 Issue: 1-2 Pages: 81-87
Publisher: Babylon University جامعة بابل

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Abstract

Carcinoma of the larynx Constitutes 1.5% of all cancers and 25% of head and neck cancer. It is etiologically related to tobacco smoking, alcohol overuse, nutritional deficiency, human papilloma virus infection and environmental pollution. The aims of the present research was to study the Prognostic Index in Laryngeal carcinoma including age, sex, clinical manifestation, histological types, and to evaluation and correlated with treatment results . 165 consecutive patients with laryngeal carcinoma who were diagnosed, treated, and / or followed at Hilla hospitals during the period (1990-2004) were studied. The total number of patient diagnosed with laryngeal Carcinoma were 165 during the fourteen years period, 129(78%)patients were males 36 (22%) were females . M: F ratio was 3.58:1. 52% of patients were between 50 and 60 years of age. There were 3 patients with carcinoma insitu (2%), (13%) in stage1, (35%) in stage 2,(35%) in stage 3 and (15%) stage 4 . Of 165 patients, 102 (62%) were treated surgically followed by radiotherapy (group 1), 35 patients (21%) treated surgically followed by Radiotherapy and chemotherapy (group 2), and 28 patients (17%) were treated by surgery & conservative treatment (group 3). For patient in group (1) the one year survival rate was 68%, the 3 year survival rate was 38% and the 5 year survival rate was 15%, for group 2 the survival rate was 48%, 30% and 14% respectively, and for group 3 the survival rate was 28%, 10% and 4% respectively. We concluded that Laryngeal carcinoma in Babylon occurred at younger age group than the western reported studies and had low one , three & five years survival rate . Further studies are needed to confirm the risk factors involved in laryngeal carcinoma and to improve the health education toward its early detection and treatment.

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Article
clinico-pathological study of leukoplakia in babylon
داء الابيضاض الفموي ( الطلوان) دراسة سريرية مرضية

Authors: Raad Ali Jassim --- Ali Hassan AL- Timimi
Journal: Journal of University of Babylon مجلة جامعة بابل ISSN: 19920652 23128135 Year: 2005 Volume: 10 Issue: 4 Pages: 635-642
Publisher: Babylon University جامعة بابل

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Article
Morphometric and pathological Study of Urinary Bladder Carcinomas: Significance of Schistosomal Fibrosis

Authors: Ali Hassan Al-Timimi --- Mohammad Sabri Abdu-Razak
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2004 Volume: 1 Issue: 3-4 Pages: 275-285
Publisher: Babylon University جامعة بابل

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Abstract

Objective measurement of microscopic features has been advocated for decades as a method to make more reproducible and "scientific" the practice of histopathology, but it is only recently that technical advances in computing have rendered this procedure suitable for diagnostic and prognostic determinations in surgical pathology. Urinary bladder cancer is the third most common malignancy in Iraq. Heavy Schistosoma haematobium infection predisposes to bladder cancer which is usually of squamous cell type and accounts for about one quarter of deaths from this infection.We investigated the extent of fibrosis in forty urinary bladder carcinomas (15 Schistosomal associated SASCC and 25 Schistosomal non-associated transitional cell carcinoma SNATCC). The cases were subjected to quantitative assessment of their fibrosis by (1) colorimetric micromethod for collagen measurement (2) morphometric assessment of collagen by use of image analyzer. The results obtained by both methods showed that SASCC were more fibrogenic than SNATCC and displaying more desmoplasia. It is concluded that the total amount of collagen in addition to the distribution pattern of the fibrotic process in schistosomal cases around the newly formed blood vessel and lymphatic both play a role in determination of the unique behavior of such neoplasm.

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