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Article
Molecular and Immunopathological Role of Nuclear Factor K B Detected By Insitu Hybridization in Pathogenesis of Chronic Atrophic Gastritis in Iraqi Patients

Author: Ali Ibrahim Ali
Journal: Diyala Journal For Pure Science مجلة ديالى للعلوم الصرفة ISSN: 83732222 25189255 Year: 2010 Volume: 6 Issue: 3 Pages: 187-214
Publisher: Diyala University جامعة ديالى

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Abstract

Chronic Atrophic gastritis (CAG) is a histopathological entity characterized by chronic inflammation of the gastric mucosa with loss of gastric glandular cells and replacement by intestinal-type epithelium and fibrous tissue. Atrophy of the gastric mucosa is the endpoint of chronic processes, such as chronic gastritis associated with Helicobacter pylori infection. This study designed to determine the molecular role of NFkB signaling on Fas receptor mediated apoptosis in H.pylori associated CAG cases. Forty five patients suffering from CAG that proved via endoscopical and histopathological examination were eligible for this study. Males represent (73.33%) and the rest (26.67%) were females with a mean age of 39.26 years .twenty apparently healthy volunteers (10 male and 10 female) with the mean age 38 years and age range (23-58) years were enrolled as control group. Multiple mucosal biopsy specimens were taken from the inflamed area of gastric mucosa for rapid urease test other biopsy specimens were fixed with 10% buffered formalin for preparation of paraffin embedded tissue blocks to prepare slides for histological examination using haematoxylin-eosin stain to evaluate the grades of Polymorphonuclear leukocytes(PMNs) and lymphocytes infiltration . Insitu hybridization technique (ISH) using biotinylated long DNA probe for human NF-KB Gene and for human FAS gene as well as H.pylori Cag A gene were used for detection of NF-KB and Fas mRNA and Cag A mRNA expression in tissue infiltrated lymphocytes and neutrophils as well as gastric epithelial cells and for detection of H.pylori Cag A. This study explained that there was a statistical significant positive linear relationship between lymphocytes grade and Fas mRNA expression in PMNs and gastric epithelial cells. PMN grade has significant positive linear relationship with each of the following markers: Tissue Fas mRNA expression. Tissue NFkB mRNA expression, lymphocytes NFkB mRNA expression, PMN NFkB mRNA expression, Cag A mRNA expression. Lymphocytes Fas mRNA expression has significant positive linear relationship with PMN Fas mRNA expression and Cag A mRNA expression .PMN Fas mRNA expression has significant positive linear relationship with Cag A mRNA expression and negative linear relationship with tissue NFkB mRNA expression . Tissue Fas mRNA expression has significant positive linear relationship with tissue NFkB mRNA expression ; lymphocytes NFkB mRNA expression ; PMN NFkB mRNA expression ;Cag A mRNA expression . Tissue NFKB mRNA expression has significant positive linear relationship with lymphocytes NFkB mRNA expression; PMN NFkB mRNA expression. Lymphocytes NFkB mRNA expression has significant positive linear relationship with PMN NFkB mRNA expression. This study conclude that NFkB play a vital role in determination of immunopathological and inflammatory events of gastritis that leads finally to development of atrophic changes


Article
Possible correlation between O-antigen serogroup of Enteropathogenic / Enteroinvasive E.coli and co infection with Giardia G.lamblia and Entamoeba histolytica as a possible pathological strategy for acute diarrhea among children of Baghdad governorate
احتمالية العلاقة مابين المجاميع المصلية للمستضد الجسماني في البكتريا المعوية

Authors: , Walaa Najm Abood --- Ali Ibrahim Ali
Journal: Diyala Journal For Pure Science مجلة ديالى للعلوم الصرفة ISSN: 83732222 25189255 Year: 2010 Volume: 6 Issue: 1 Pages: 205-226
Publisher: Diyala University جامعة ديالى

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Abstract

Diarrheal diseases account for approximately 2 million deaths annually in children under the age of 5years. Disease and death caused by diarrhea is a global problem, but is especially prevalent in developing countries. The aim of the present study is to determine the possible role of E.coli mainly Enter pathogenic (EPEC) serogroup (O111, O55, O26, O86, O119, O127, O114, and O142) and Enteroinvasive E.coli (EIEC) serogroup (O124); Giardia lambleia and Entamoeba histolytica co infections in pathology of acute diarrhea among children's of Baghdad governorate. A total of one hundred seventy presented with diarrhea that proved through clinical investigation were enrolled in this study. After microbiological examinations, Sixty four children that infected with two pathogens were selectively enrolled in this study. The minimum age of infected children was 4 months while maximum age was 116 months. Thirty four (53.1%) % out of Sixty four children were males and females represent the rest 30(46.9%). Stool samples of patients were submitted for direct microscopical examination for detection of G.lamblia and E.histolytica using wet preparation technique. Gram staining technique was applied for demonstration of gram negative bacilli. Stool culture was done using MaCconky agar for determination of E.coli. API 20E system was used for biochemical characterization of E.coli .serogrouping of E.coli was done by direct slide agglutination technique in to four types (type1 EPEC serogroup ( O111,O55,O26 ), type 2 EPEC serogroup ( O86,O119,O127), type3 EPEC serogroup ( O125,O126,O128 ), type 4 EPEC/EIEC serogroup ( O114,O124,O142 ) using Specific trivalent antisera. In this study the critical age groups were (4-20)month followed by (21-37) month and (38-54) which represent (31.25%) , (28.12%) and (25%) of infected cases . on the other hand the age group (106-122) month was consider less critical age of infection with diarrhea causative agents. Among the age group (4-20) month, infection with E.histolytica represent (21.87%) while infection with EPEC serogroup (O86, O119, O127)represent (12.5%) out of 64 infected children. infection with G.lamblia represent (6.25%) while at this age group the low detectable frequency of infection was caused by EPEC /EIEC serogroup (O114, O124, O142), (3.12 %) with no detectable frequency of infection with EPEC serogroup ( O111,O55,O26)and EPEC serogroup (O125, O126, O128). Regarding age group (21-37) month high frequency (25%) of infection with E.histolytica was recorded compared with (6.25%) for EPEC serogroup (O86,O119,O127), and EPEC /EIEC serogroup ( O114,O124,O142 ). low detectable frequency (3.12%) of infection was caused by G.lamblia .At the age group (38-54) month high frequency of infection with E.histolytica was recorded (18.75%) compared with (3.12%) for EPEC /EIEC serogroup ( O114,O124,O142 ), G.lamblia . Equal frequency of infection was recorded for EPEC /EIEC serogroup (O114, O124, O142) and G.lamblia (6.25%) in the age group (55-71) month as well as for E.histolytica (6.25%) in the age group (72-88) month and (3.12%) in the age group (106- 122) month . E.histolytica was more frequent pathogen that detected in (75%) of diarrheal cases followed by EPEC serogroup (O86, O119, O127), (21.9%), EPEC /EIEC serogroup (O114, O124, O142) and G.lamblia (18.8%) for each one. This study revealed that co infection with EPEC serogroup (O86, O119, O127) and E.histolytica represent (15,62%),while co infection with EPEC / EIEC serogroup ( O114,O124,O142) and G.lamblia represent (9.73%).on the other hand co infection with EPEC / EIEC serogroup (O114,O124,O142)and E.histolytica represent (9.73%).This study revealed that there was positive linear relationship between age of infected children and infection with EPEC serogroup (O86, O119, O127) (r=.367;p=.039. strong negative linear relationship between EPEC / EIEC serogroup ( O114,O124,O142 ) and E.histolytica infection( r= -.462;p=.008) as well as between G.lambelia and E.histolytica infection (r=-.832;p=.000) .This study concludes that there is a possible correlation between O-antigen Serogrouping and coinfection with EPEC / EIEC, EPEC, G.lambelia and E.histolytica.

امراض الاسهال مسؤله عن مايقارب مليونا حاله وفاه سنوياً في الاطفال تحت سن الخامسه.المرض و الموت المسبب عن الاسهال هما مشكله عالميه ولكنها تتركز في البلدان الناميه .تهدف الدراسه الحاليه لتحديد الدور المحتمل الاصابه المتزامنه بـ Enteropathogenic (EPEC) serogroup (O111, O55, O26, O86, O119, O127, O114, و O142) and Enteroinvasive E.coli (EIEC) serogroup (O124); Giardia lamblia and Entamoeba histolytica كاستراتيجيه مرضيه محتمله للاسهال الحاد بين اطفال محافظه بغداد . مائه وسبعون طفلاً يعانون من الاسهال الحاد المثبت سريريا تم اختيارهم في هذه الدراسه . بعد اجراء الفحوصات المايكروبايولوجيه على هؤلاء المرضى تم اختيار اربع وستون طفلاً مصابا بمسببين مرضيين .اقل عمر الاطفال المصابين كان اربعه اشهر في حين اعلى عمر كان (116) شهر.اربعه و ثلاثون طفلاً (53.1%) كانوا من الذكور بينما تمثل الاناث (46.9%).. تم اجراء الفحص المجهري المباشر على عينات البراز للمرضى لتحديد الاصابه بـ G lamblia و E. histolytic باستخدام تقنيه التحضير الرطب.تم استخدام تقنيه كرام لصبغ عينات البراز على الشرائح الزجاجيه. زرعت عينات البراز على وسط MaCconky agar لتحديد الاصابه بـ E.coli . نظام API 20E استخدم للتمييز البايوكيميائي لـ E.coli..التقسيم الى مجاميع مصليه جرى باستخدام تقنيه التلازن المباشر على الشريحه الزجاجيه الى اربعه مجاميع مصليه باستخدام مضادات مصول ثلاثيه خاصه (type1 EPEC serogroup ( O111,O55,O26 ), type 2 EPEC serogroup ( O86,O119,O127), type3 EPEC serogroup ( O125,O126,O128 ), type 4 EPEC/EIEC serogroup ) O114,O124,O142 ) ). في هذه الدراسه كانت المجاميع العمريه الحرجه للاطفال المصابين هي (4-20) ) شهر ; (21-37) month and (38-54) شهر والني تمثل (31.25%) , (28.12%) , (25%) بالتعاقب. من جانب اخر اقل الجاميع العمريه حراجه للاصابه بمسببات الاسهال كانت (106-122) شهر.بين المجموعه العمريه (4-20) شهر كانت الاصابه بـ E.histolytica تمثل (21.87%) في حين تمثل الاصابه بـ EPEC المجموعه المصليه (O86, O119, O127) تمثل (12.5%) في حين الاصابه بـ G.lamblia تمثل (6.25%) بينما اقل نسبه اصابه في هذه المجموعه العمريه كانت(3.12 % المسببه عن الاصابه بـ EPEC /EIEC serogroup (O114, O124, O142). لم يتم تحديد اي نسبه اصابه بـ (EPEC serogroup ( O111,O55,O26 ), EPEC serogroup (O125, O126, O128)..فيما يخص المجموعه العمريه (21-37) شهر اعلى نسبه اصابه بـ E. histolytica كانت (25%) مقارنه بـ 6.25%) ) لكل من EPEC serogroup (O86, O119, O127)وEPEC /EIEC serogroup ( O114,O124,O142 ) في حين كانت نسبه الاصابه 3.12%)) لـG.lamblia .في المجموعه العمريه 38-54) ) شهر سجلت اعلى نسبه اصابه ب E. histolytica ـ (18.75%) مقارنه بـ .12%)3) لـ ((EPEC /EIEC serogroup ( O114,O124,O142 ,و G.lamblia..نسبه اصابه متساويه (6.25%) سجلت لكل من EPEC /EIEC serogroup (O114, O124, O142) و G.lamblia في المجموعه العمريه(55-71) شهر كذلك كانت نسبه الاصابه بـ E.histolytica للمجموعه العمريه (72-88) شهر 6.25%) )بينما في المجموعه العمريه (106- 122) شهر كانت نسبه الاصابه (3.12%) .اعلى نسبه اصابه بمسببات الاسهال كانت بسبب E. histolytica(75%) بينما(21.9%) حددت نسبه الاصابه بـ EPEC serogroup(O86,O119,O127). حددت نسبه اصابه متساويه(18.8%) لكل من EPEC /EIEC serogroup (O114, O124, O142) G.lamblia . اوضحت هذه الدراسه بان نسبه الاصابه المتزامنه EPEC serogroup (O86, O119, O127)و E.histolytica تمثل (15,62%),و الاصابه المتزامنه EPEC / EIEC serogroup ( O114,O124,O142 ) و G.lamblia تمثل (9.73%) . من جانب اخر كانت نسبه الاصابه المتزامنه بـEPEC serogroup (O114,O124,O142)و E.histolytica. تمثل (9.73%). بينت هذه الدراسه وجود علاقه خطيه موجبه بين عمر الاطفال المصابين بالاسهال و الاصابه بـ EPEC serogroup (O86, O119, O127 . كانت هناك علاقه خطيه سالبه للاصابه بـ Entamoeba histolyticaو EPEC / EIEC serogroup O114,O124,O142 )). علاقه خطيه سالبه للاصابه بـ E. Histolytica و G.lamblia تم تسجيلها.استنتجت هذه الدراسه احتماليه وجود علاقه بين المجموعه المصليه لـ EPEC / EIEC وتزامن الاصابه بـ E. histolytica و G.lamblia


Article
Performance of Anticyclic Citrullinated Peptide Antibodies versus Rheumatoid Factor in diagnosis of Rheumatoid Arthritis

Authors: Mohammed Jasim محمد جاسم --- Ali Ibrahim Ali علي ابراهيم علي
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2011 Volume: 1 Issue: 1 Pages: 81-90
Publisher: Diyala University جامعة ديالى

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Abstract

The aim of this study was to evaluate the performance of anti-cyclic citrullinated peptide antibodies (anti-ccp) versus Rheumatoid Factor (RF) in the diagnosis of rheumatoid arthritis in serum sample of patients with clinical manifestation of arthritis using ELISA technique.One hundred and twenty patients with clinical presentation of rheumatoid arthritis and fifty apparently healthy individuals (25 males and 25 females) were enrolled in this study. The mean age of patients group and control was 36.45years versus 34.72 years .Among patients, males represented (8.3%) compared with (91.7%) of females. In control group males represented (52%) versus (48%) females.There was a statistical significant difference (p>0.05) between patients and control group in RF and anti-ccp values. Eighty five percent of patients gave positive results for anti-ccp compared with (100%) negative results in control group. RF was detected in (41.66 %) of patients sera compared with (58.33 %) which gave negative results. RF ELISA gave negative results in (100%) of control group .Only 10(8, 33%) out of 120 patients gave negative results in RF and anti-ccp ELISA, compared with 42(35%) out of 120 gave positive results in both tests. In 60(50%) out of 120 RA patients RF gave negative results and at the same time gave positive results when retested using anti-ccp ELISA .Only 8(6.66%) out of 120 RA patients gave negative result in anti-ccp ELISA technique and RF was detected in positive value.The sensitivity of anti-ccp ELISA was (85%) versus (41.66%) for RF. The Specificity of anti-ccp ELISA was (55.55%) versus (14.28%) for RF. Positive predictive value for anti-ccp ELISA was 41.17% versus (84%) for RF. Negative predictive value for anti-ccp ELISA was 55.55% versus 14.28 for RF ELISA .False positive value in anti-ccp ELISA was 58.82% versus 16%for RF ELISA. False negative value in anti-ccp ELISA was 44.44% versus 85.71%for RF .This study concludes that anti-ccp ELISA was more sensitive and specific in diagnosis of RA than RF ELISA technique.

Keywords

RA --- RF --- Anti-ccp --- ELISA --- sensitivity --- Specificity.


Article
Molecular and immunopathological role of nuclear factor k b detected by insitu hy-bridization in pathogenesis of chronic atrophic gastritis in Iraqi patients
دور الجزيئية وimmunopathological عامل كيلوبايت النووية الكشف عنها بواسطة المكانية HY-bridization في التسبب في التهاب المعدة الضموري المزمن في المرضى العراقيين

Author: Ali Ibrahim Ali AL-EZZY علي ابراهيم علي
Journal: The Medical Journal of Tikrit مجلة تكريت الطبية ISSN: 16831813 Year: 2013 Volume: 19 Issue: 2 Pages: 239-255
Publisher: Tikrit University جامعة تكريت

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Abstract

Background/ aim: Chronic atrophic gastritis (CAG) characterized by chronic in-flammation of gastric mucosa with loss of gastric glandular cells and replacement by intestinal-type epithelium and fibrous tissue. CAG may be associated with Helicobacter pylori infection. This study was designed to determine the role of NFkB signaling on Fas receptor mediated apoptosis in H.pylori Cag A+ associated CAG. Methods: According to exclusion criteria (45) CAG patients and (20) control were chosen. Multiple gastric mucosal biopsies were taken for rapid urease test and preparation of slides from paraffin blocks. Slides stained with haematoxylin-eosin for histopathology and grading of PMNs and lymphocytes. Biotinylated DNA probe for human NF-KB and FAS genes were used for detection of their expression in tissue lymphocytes, PMNs and gastric epithelial cells using ISH technique. Biotinylated DNA probe for H.pylori Cag A gene was used for detection of its expression in gastric epithelial cells. Results: lymphocytes grade has positive correlation with Fas mRNA expression in PMN and gastric epithelial cells. PMN grade has positive correlation with tissue Fas mRNA; tissue NFkB mRNA; Cag A mRNA; lymphocytes and PMN NFkB mRNA expression. Lymphocytes Fas mRNA has positive correlation with PMN Fas mRNA and Cag A mRNA expression .Tissue Fas mRNA has positive correlation with tissue NFkB mRNA; Cag A mRNA ,lymphocytes and PMN NFkB mRNA expression. Tissue NFKB mRNA has positive correlation with lymphocytes and PMN NFkB mRNA expression. Conclusion: NFkB play vital role in Immunopathology of H.pylori Cag A+ associated gastritis that leads finally to atrophic changes.

الخلفية / الهدف: التهاب المعدة الضموري المزمن ( CAG ) التي تتميز المزمنة في flammation من الغشاء المخاطي في المعدة مع فقدان الخلايا الغدية المعدة و الأمعاء عن طريق استبدال من نوع ظهارة و النسيج الليفي . CAG قد تترافق مع العدوى هيليكوباكتر بيلوري . وقد تم تصميم هذه الدراسة إلى تحديد دور NFkB يشير فاس على مستقبلات بوساطة موت الخلايا المبرمج في H.pylori CAG A + CAG المرتبطة بها. الأساليب : وفقا ل معايير الاستبعاد ( 45 ) من المرضى CAG و تم اختيار ( 20 ) السيطرة. أخذت خزعات المخاطية في المعدة متعددة ل اختبار اليورياز السريع و إعداد الشرائح من كتل البارافين. الشرائح ملطخة haematoxylin - يوزين لل التشريح المرضي و الدرجات من PMNs و الخلايا الليمفاوية . واستخدمت التحقيق الحمض النووي البيروكسيديز ل NF -KB و FAS الجينات البشرية للكشف عن التعبير عنها في الخلايا الليمفاوية الأنسجة، و الخلايا الظهارية PMNs المعدة باستخدام تقنية ISH . مسبار الحمض النووي البيروكسيديز ل H.pylori CAG تم استخدام الجينات للكشف عن التعبير عنها في الخلايا الظهارية المعدة. النتائج : الخلايا الليمفاوية الصف ديه علاقة إيجابية مع فاس التعبير مرنا في PMN و الخلايا الظهارية في المعدة. PMN الصف ديه علاقة إيجابية مع الأنسجة فاس مرنا ؛ الأنسجة NFkB مرنا ؛ المساعدة النقدية و مرنا ؛ الخلايا الليمفاوية و PMN NFkB مرنا التعبير. الخلايا الليمفاوية فاس مرنا لديه علاقة إيجابية مع PMN فاس مرنا و المساعدة النقدية و التعبير مرنا الأنسجة فاس مرنا لديه علاقة إيجابية مع الأنسجة NFkB مرنا ؛ المساعدة النقدية و مرنا ، و الخلايا الليمفاوية PMN NFkB مرنا التعبير. الأنسجة NFKB مرنا لديه علاقة إيجابية مع الخلايا الليمفاوية و PMN NFkB مرنا التعبير. الاستنتاج : دور حيوي اللعب NFkB في الباثولوجيا المناعية من H.pylori CAG A + التهاب المعدة المرتبطة بها والتي يؤدي في النهاية إلى تغييرات ضامرة.


Article
Performance of Serological Diagnosis of TORCH Agents in Aborted versus non aborted Women of Waset province in Iraq
أداء التشخيص المصلي من وكلاء الشعلة في المرأة المجهضة أجهض مقابل عدم مقاطعة واسط في العراق

Author: Mohammed Jasim , Hadeel A. Majeed, Ali Ibrahim Ali محمد جاسم، هديل عبد المجيد ، علي ابراهيم علي
Journal: The Medical Journal of Tikrit مجلة تكريت الطبية ISSN: 16831813 Year: 2011 Volume: 2 Issue: 172 Pages: 141-147
Publisher: Tikrit University جامعة تكريت

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Abstract

The aim of this study was to evaluate associations between prevalence of TORCH (Toxoplasma gondii, Rubella virus, Cytomegalovirus, Herpes simplex virus) infections and abortion in pregnant women in Waset government of Iraq. Three hundred blood samples were collected from women having bad obstetric history (BOH) out of 300, 162 have a history of spontaneous abortion, serum was separated and tested for IgM antibodies against TORCH using enzyme-linked immunosorbent assay (ELISA) .In abortion women IgM seropositivity was found as Toxoplasma 54% (P <0.05), Rubella_62.3% (P <0.05), CMV_60.2% (P> 0.05) and HSV_73.9% (P> 0.05). High percentage of repeated abortion (two and three or more) see in women seropositivity for CMV IgM and Rubella IgM 12.4% (P> 0.05) 5.7% (P <0.05) respectively, CMV and HSV infection have a statistically significant correlation with the incidence of abortion in addition the significant role of CMV infection of repeated abortion. So routine screening of all women in child bearing age, it shows the need to provide health edu-cation to pregnant women.

وكان الهدف من هذه الدراسة لتقييم الارتباط بين انتشار المشعل (جوندياي التوكسوبلازما، فيروس الحصبة الألمانية، الفيروس المضخم للخلايا، فيروس الهربس البسيط) الالتهابات والإجهاض عند النساء الحوامل في الحكومة واسط من العراق. تم جمع عينات الدم وثلاث مئة من النساء وجود سوء التوليد التاريخ (بوه) من أصل 300، 162 لديهم تاريخ من الإجهاض التلقائي، تم فصل مصل الدم واختبار الأجسام المضادة ضد الغلوبولين المناعي TORCH باستخدام انزيم مرتبط المناعي فحص (ELISA). في النساء الإجهاض تم العثور على الغلوبولين المناعي إيجابية المصل كما التوكسوبلازما 54٪ (P <0.05)، Rubella_62.3٪ (P <0.05)، CMV_60.2٪ (P> 0.05) وHSV_73.9٪ (P> 0.05). نسبة عالية من الاجهاض المتكرر (اثنين وثلاثة أو أكثر) انظر في إيجابية المصل للنساء الغلوبولين المناعي CMV و IgM الحصبة الألمانية 12.4٪ (P> 0.05) 5.7٪ (P <0.05) على التوالي، وCMV عدوى فيروس الهربس البسيط لها علاقة ذات دلالة إحصائية مع الإصابة من الإجهاض، بالإضافة إلى الدور الهام للعدوى الفيروس المضخم للخلايا من الإجهاض المتكرر. الفحص الروتيني لذلك لجميع النساء في سن الإنجاب، فإنه يدل على الحاجة إلى توفير الصحة EDU-الموجبة للنساء الحوامل.


Article
Clinical Usefulness of IgE as a Serological Marker for Diagnosis of Nodular Scabies in Diyala Province

Authors: Burug Mohammad براق محمد --- Ali Ibrahim Ali علي ابراهيم علي --- Khudir khalaf Ibrahim خضير خلف ابراهيم
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2012 Volume: 2 Issue: 1 Pages: 60-65
Publisher: Diyala University جامعة ديالى

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Abstract

This study designed to evaluate the clinical usefulness of IgE as a serological marker for diagnosis of nodular scabies.Sixty eight patients suffering from nodular scabies and twenty apparently healthy subjects as control group were included .The mean age of patients group was ( 31.67±1.67)years compared with (33.5 ±2.27) years in control group .Among patients group, males represent(76.5%) compared with (23.5%) females. Among control group males represent (55%) versus (45%) females .The mean of IgE concentration among control group was (59.25 ± 5.36 U/ml) compared with (160.16 ±16.78 U/ml )among patients group with statistical significant difference (p>0.05 ).In (34/ 68) of scabietic patients, the concentration of IgE was lower than cutoff concentration with the mean (46.23 ±5.09IU/ml ).The rest (34/ 68) scabietic patients have elevated concentration of IgE(274.08 ±18.18IU/ml ).There was a statistical significant difference (p>0.05) between patients groups in IgE concentrations.This study concludes that the diagnostic value of IgE as a serological marker cannot be considered as a single parameter for diagnosis of nodular scabies without clinical manifestations. This study proved that the serological concentration of IgE not necessarily elevated in all cases of nodular scabies

Keywords

nodular scabies --- IgE --- serology --- diagnosis

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