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Cephalometric analysis of craniofacial deformity of β- thalassemic major by using computed tomography

Authors: Alia T. Thajeel --- Jamal Ali Al-Taei جمال علي الطائي
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2013 Volume: 25 Issue: 4 Pages: 39-43
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Thalassemia is a hereditary anemia resulting from defects in hemoglobin production. β- thalassemiacaused by decrease in the production of β- globin chains affect multiple organs and is associated with cranio-orofacialdeformity which include prominent cheek bones and protrusive premaxilla with depression of the nasal bridgeoften referred to as “rodent or chip-munk face” with small mandible and Cl.II skeletal relationship. This study aimed toinvestigate cephalometric craniofacial parameters (skeletal) of β- thalassemic major patients by using computedtomography and to compare findings with a group of healthy patients in the same age group.Subject, Materials and Method: The study included (40) patients with β- thalassemic major (20 female and 20 male)with age 8-15years compared with (40) healthy controls (20 female and 20 male) with the same age, who admittedto spiral computed tomography scan unit in X-ray institute in AL-KARKH general hospital to have computedtomography scan for the brain, paranasal and for orthodontic purpose from October 2011 to June 2012.Cephalometric analysis of the selected four skeletal linear measurements and four skeletal angular measurements,by using direct analysis with software programs in a computer which is part of the computed tomography machine.Results: There was no statistically significant difference between thalassemic males and females in all selectedskeletal linear and angular measurements, Thalassemic patients have a highly significant large ANB angle and cl IIskeletal relationship, significant larger gonial angle, Mandibular base length (Me-Go) is significantly shorter,Retrognathic mandible (SNB) is significantly decreased, highly significant shorter in total anterior facial height (N-Me)and total posterior facial height (S-Go), and also the Ramus height is highly significant decreased.Conclusion: In thalassemic patients, the skeletal morphology is recognizable and mandible is retrognathism and theyhave skeletal cl. II pattern and Computed tomography is useful tool for assessment of the cranio facialmeasurement.

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