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High Risk Factor Values of Cardiovascular Disease and Uric Acid Levels in Sera of Patients with Type 1 Diabetes Mellitus

Authors: Asim A.Alsalihy --- Khowla A. Shemran --- Abdulsamie H. Alta’ee عبدالسميع حسن الطائي --- Mufeed J. Ewadh --- et al.
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2004 Volume: 1 Issue: 3-4 Pages: 225-233
Publisher: Babylon University جامعة بابل

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Abstract

Diabetes mellitus is a chronic illness required ongoing medical care. As a result, laboratory testing has become an essential part of the evaluation and monitoring process in diabetes management. Further tests are required to establish the correlation between hyperglycemia and other disease parameter. Therefore, the correlation between cardiovascular disease risk factor values and uric acid levels in sera of adult patients with type 1 diabetes mellitus (without renal diseases) and healthy controls have been studied. Total cholesterol, HDL-cholesterol and uric acid in sera of 52 patients (36 males and 16 females) with poor hyperglycemic control type 1 diabetes mellitus and 30 healthy controls (19 males and 11 females) were determined. Results of present study show significantly higher risk factor values (P < 0.001), which means increasing in the probability of atherosclerosis incidence. Also hyperglycemia found to be associated with hyperuricemia in type 1 diabetic patients.

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Article
Epidemiological Study of Lipid Profile in Aldiwaniya Governorate

Authors: Amjed H.Salman --- Khowla A.Shemra --- Asim A.Alsalihy --- Hussien S. Al-Janabi --- et al.
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2004 Volume: 1 Issue: 2 Pages: 128-136
Publisher: Babylon University جامعة بابل

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Abstract

During the past decade, numerous experimental and clinical srudies have demonstratecl that many common conditions predisposing to cardiovascular disease, such as hypercholesterolemia,hypertension, diabetes, and smoking. Thus a population-based study in Aldewaniya city was conducted in sera of432 people (201 males,231 fenales) randomly chosen to define the Drevalence of va oustype of hypertipidaemia and to establish the reference ranges of serum toiat chotesterol (TC),triglycerides (TG), low-densiq, lipopotein (LDL) cholesrerol, very low-densiry lipoprorein (VLDL)cholesterol, and high-density lipoprotein (HDL) choleslercl. peopte subjects to present study wereclassified into seven age goups e20-<70 years). The prevalenco of hperlipidaemia was higher infemaies than mal€s. TC, TG, LDl-cholesrerol. and VlDLcholesterol found to be associated withprogressive of age. IlDl-cholesterol found to be depleted with Fogressive of age

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Article
Diabetes Mellitus Correlation with Free Radicals and Creatine Kinase Isoenzymes Activity

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Abstract

To explain the relationship between free radicals production in experimentally diabetic animals and expected glutathione (GSH) reducing levels with its enhancement due to feeding of cysteine, N-acetyl cysteine and to evaluate the action of antioxidant to relief the damage to the active site of creatine kinase (CK) caused by free radicals, three doses during 48 hours of 150 mg alloxan / kg body weight was injected to forty eight males albino mice to produce the diabetes mellitus. Blood glucose and serum glutathione were determined using colorimetric methods, whereas, fractionation of CK isoenzymes in sera of diabetic mice was conducted by mini column ion exchange chromatography using Sephadex A-50. Agarose gel electrophoresis was used to quantitize the CK isoenzymes. Results of present study show that after long period of induced diabets in males albino mice cause a change in CK isoenzyme distribution pattern The total serum CK activity decreased in 75% of animals and reached to 63.5% of the control value whereas CK - MM isoenzyme was also decreased to 54.1% of its initial activity. Other isoenzymes showed variation depending upon the period of diabetes induced which caused elevated levels after 30 days of CK -BB isoenzyme in 62.5% of the animal studied and reached to 68% more than its initial activity which in < 3%. CK - MB which is found in 25% of albino mice was elevated to 17.1% more than that found in control sera which is < 3%. Insulin affects total CK activity and its isoenzymes distribution pattern as a therapeutic agent, and CK activity found to be elevated Thiol containing compounds including cysteine, N-acetyl cysteine dithiothreitol and glutathione have been suggested to reactivate the CK activity.

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