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Article
Light Microscopic Investigation of Developing Rat Teeth After Atenolol Drug Administration (Experimental Study)

Author: Asmaa S Al-Douri
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2011 Volume: 11 Issue: 22 Pages: 331-345
Publisher: Mosul University جامعة الموصل

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Abstract

Aims: To investigate the effect of atenolol drug on the formation and development of rat dentition of rat (histologically and histochemically). Materials and Methods: Albino Wister rats were divided into two main groups,. The control group and experimental group, each consisted of (9) pregnant rats, giv-en 1 ml distilled water and 10 mg atenolol (powder) suspended in 1ml distilled water , orally , as a single dose, respectively from 12 – 18 day of gestation, after delivery of pregnanent rats, 36 newborn were selected to be scarified at ages 1, 5. and 10 post nataly from each group. The specimens were pre-pared for processing and stained with H&E and alcian blue stains. Results: The treated groups showed obvious histological changes: delay in tooth germ formation, increase blood vascularity, disorganiza-tion of ameloblast and odontoblast cells, and delay in glycosaminoglycan synthesis. Conclusions: Atenolol drug delay the rat tooth development causing abnormal odontogenic changes and inhibits gly-cosaminoglycan synthesis.

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Article
Histometric Evaluation of Atenolol Effect on Developing Rat Dentition: Experimental Study

Author: Asmaa S Al-Douri
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2012 Volume: 12 Issue: 23 Pages: 153-159
Publisher: Mosul University جامعة الموصل

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Abstract

Aims: To investigate the histometric effect of atenolol drug on the developing dentition of rats. Mate-rials and Methods: The pregnant rats were divided into two main groups; control and atenolol treated groups. The control pregnant rats were given 1 ml distilled water orally from 12 – 18 day of gestation period, after delivery of these rats, thirty newborn rats from six mothers were sacrificed at ages 1, 5, 10 days postnataly (p.n). The experimental group were given 10 mg atenolol powder suspended in 1 ml distilled water orally, daily as a single dose from 12 – 18 day of gestation, thirty newborn rats from each six mothers were sacrificed at ages 1, 5, 10 days postnataly. The specimens were prepared for processing and staining with Hematoxyline and Eosin stains, and then examined by Motic microscope. Histometric measurements were under taken for these specimens by graticule lense. The histometric parameters used are the dentin thickness, mesiodistal dimension of molar teeth, pulp density (cellulari-ty) and eruption rate. Results: The results showed that atenolol affect on the developing rat dentition .This manifested by less dentin thickness, decreased mesiodistal dimension, increase in pulp cellularity and delay in eruption rate of lower incisor tooth in the atenolol treated groups in comparison to the con-trol groups. These observed changes are proceeded or continued as development process until last ex-premintal age 10 p.n. Conclusions: Atenolol drug delay the tooth development and affect it.


Article
The Effect of Honey on the Healing of Oral Ulcers(Clinical Study).

Authors: Asmaa S Al-Douri --- Shatha S Mohamed
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2008 Volume: 8 Issue: 16 Pages: 157-160
Publisher: Mosul University جامعة الموصل

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Abstract

Aim: to assess the effect of honey on healing of recurrent aphthous ulcers. Materials and Methods:fifty patients with minor oral ulcers (2–5 mm) were attended to consultant clinic in the College of Dentistry demanding a treatment for their painful ulcers were treated by either kenalog in orabase or theapplication of honey dressing. Results: The ulcerations have almost completely disappeared after 3 days treatment by honey dressing. Conclusions: Honey has an obvious influence on the rate of healingprocess of the oral ulcers.

Keywords

Ulcers --- healing --- honey


Article
The histochemical effects of the administration of hydrocortisone sodium succinate upon the periodontium of albino rats' experimental study

Author: Asmaa S. Al-Douri اسماء الدوري
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2005 Volume: 17 Issue: 2 Pages: 59-63
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: The effects of the administration of cortisone upon numerous body tissues have been described; changes in the periodontal tissue of developing albino rats (newborn) histochemically have not been described. A study was therefore, under taken to investigate the effect of administration of cortisone upon the periodontal ligament tissues.Materials and methods: Experimental animals (new born rats, their age 10, 19, 25 days old) were treated by cortisone, saggital sections were stained by alcian blue and H&E stains.Results: It was shown that the hydrocortisone sodium succinate affect that periodontal tissue development and this drug inhibit and delay the synthesise of GAGs (glycosaminoglycans) till aged 25 post natal (p.n.).Conclusion: The periodontal membrane in the treated groups is affected (delay in the GAGs synthesis) by the hydrocortisone sodium succinate drug administration


Article
The effects of the administration of hydrocortisone sodium succinate on the periodontium of albino rats (experimental histochimical study).

Author: Asmaa S. Al-Douri اسماء الدوري
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2005 Volume: 17 Issue: 3 Pages: 48-52
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: The effects of the administration of cortisone upon numerous body tissues has been described, changes in the periodontal tissue of developing albino rats (newborn) histochemically have not been described. A study was therefore, under taken to investigate the effect of administration of cortisone upon the periodontal ligament tissues.Materials and methods: Experimental animals (new born rats, their age 10, 19,25 days old) were treated by cortisone,saggital section were stained by alcian blue and H&E stains.Results: Hydrocortisone sodium succinate affect that periodontal tissue development and this drug inhibit and delay the synthesise of GAGs (glycosaminoglycans) till aged 25 post natal (p.n.).Conclusion: The periodontal membrane in the treated groups is affected (delay in the GAGs synthesis) by the hydrocortisone sodium succinate drug administration


Article
The Effect of Nigella Sativa Oil (Black Seed) on the Healing of Chemically In-duced Oral Ulcer in Rabbit (Experimen-tal Study)

Authors: Asmaa S AL-Douri --- Sahar Gh A Al-kazaz
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2010 Volume: 10 Issue: 19 Pages: 151-157
Publisher: Mosul University جامعة الموصل

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Abstract

Aims: To find out the effect of topical Nigella Sativa oil on healing of chemically induced oral ulcer. Materials and Methods: Twelve rabbits were used and divided into control and treated groups, the ulcers were induced by injection of 0.3 ml 1%formalin in rabbit cheek mucosa and were treated by daily application of black cumin (N.S) twice on the ulcer site for 3days then the animals were sacri-ficed 5days later. Results: Nigella Sativa (N.S) showed marked anti inflammatory activity on a chemi-cally induced oral ulcer in experimental animals ,histological examination of biopsies from ulcers after three days of treatment revealed difference in the rate of epithelization and healing process of ulcers between the two groups, N.S treatment showed significant enhancement of healing of the ulcers. Con-clusions: Nigella Sativa oil has an obvious effect on the rate of healing process of oral ulcer.


Article
Glycoconjugates cytochemistry in teeth development in normal and hydrocortisone treated rats (experimental study)

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Abstract

Background: This study was designed to investigate the expression of glycoconjugates in rat teeth germs at various stages and to evaluate the effect of hydrocortisone on the formation and development of dentition of the rat histochemically.Materials and methods: Foetuses of albino rats were divided into tow main groups, the control group were injected with one ml distilled water (12-18day of gestation) and experimental group were injected with one ml hydrocortisone sodium succinat (12-18day of gestation) then specimens were stained with H & E and lectinsResults: The developing teeth are effected by the hydrocortisone sodium succinate drug at all stages of tooth development, lectins used through this study can serve as a marker for tooth development process, sugar residues (Glc NAC, GLC, Gal, Gal NAC) are carbohydrate components of predentin of the control group while less residus were found in the treated groups and they were to a less extent at the inner dental BM (basement membrane).Conclusion: This drug affect rat teeth development, the abnormalities are confirmed by the stains H and E, and lectins

Keywords

Hydrocortisone --- rat --- lectins

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