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Histological and immunohistochemical evaluation of the effect of local exogenous application of VEGF on bone healing (experimental study in rat)

Authors: Enas Fadhil ايناس فاضل --- Athraa Y. Alhijazi عذراء يحيى الحجازي
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2014 Volume: 26 Issue: 4 Pages: 108-115
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: The repair of bone defects remains a major clinical orthopaedic challenge. Bone is a highlyvascularised tissue reliant on the close spatial and temporal connection between blood vessels and bone cells tomaintain skeletal integrity. Angiogenesis thus plays a pivotal role in skeletal development and bone fracture repair.The role of angiogenic and osteogenic factors in the adaptive response and interaction of osteoblasts andendothelial cells during the multi step process of bone development and repair will be highlighted in this study. Thisstudy aimed to identify the role of local exogenous vascular endothelial growth factor in bone healing and toanalyze the expression of VEGF by immunohistochemistry in created bone defect after application with differentbiomaterials in a rat model.Materials and methods: In this experimental study eighteen male Albino rats, weighing (300-400) gram, aged (6-8)months were used and maintained under control conditions of temperature, drinking and food consumption. Theanimals were subjected for a surgical operation of medial sides of both tibiae bone ( right side was considered asexperimental site ,while left be the control one), in control group the bone defect treated with local application of1μm of normal saline, while experimental treated with local application of 1μm of VEGF .The rats were sacrificed at3,7,10 days after surgery(six rats for each period). Bone healing was histologically examined withimmunohistochemical localization of VEGFResults: Bone defect treated with local application of VEGF shows an early osteoid tissue deposition with high cellcount for osteoblast, osteocyte and osteoclast. Immunohistochemical evaluation for VEGF by stromal cells, reportedto be higher with significant difference in VEGF group in comparison to control.Conclusion: The study illustrated that low application of VEGF could be an effective therapeutic expression for boneinjuries; these data are promising for a possible future clinical usage


Article
Physical and Histological Evaluation of Coated Implant with Nano ZrO2 after Creation Titania Nanotubes

Authors: Mustafa Sh. Alhilfi --- Athraa Y. Alhijazi عذراء يحيى الحجازي
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2016 Volume: 28 Issue: 4 Pages: 89-95
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Contact between implant material and bones must be strong and fast creation, to fulfill these properties appropriate surface modifications must apply on used implants. In this contribution; double surface modifications are applied on Ti-6Al-4V alloy to accelerate osseointegration.Materials and methods: Anodic process is utilized to create titania nanotubes (TNTs) on the screws made from Ti-6Al-4V alloy. These implants were coated with nano ZrO2 particles. Second modification was annealing anodized screws at 8000C, and implanted in tibiae of nine adult New Zealand white rabbits.Results: Physical and histological consequences of two surface modifications on Ti-6Al-4V alloy screws were studied. Scanning electron microscope (SEM) images shows inhomogeneous distribution of TNTs on screws surfaces. X-ray diffraction (XRD) patterns illustrate the covering of first group samples with ZrO2 and transformation of Ti to its oxide (Rutile phase) for second group. These pattern shows that TiO2 had higher crystallinity and larger grain size than ZrO2. Atomic Force Microscopy images (AFM) shows the increasing of roughness, grain size and internal diameter of TNTs after annealing process. Coated implant with ZrO2 at 4 month duration shows threads with newly Haversian canal feature. Annealed implant at same duration shows well developed threads, base of implant illustrates bone trabeculae filled the base of implant bed with active osteoblast cells.Conclusion: Modification of implant's surface produced an improvement of osseointegration in comparison to untreated one.


Article
Influence of oral zinc sulphate supplementation on the development of the teeth and jaws of growing rat (Histological study)

Authors: Athraa Y. Alhijazi عذراء يحيى الحجازي --- Dhuh H. Al-Bayati ضحى البياتي
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2011 Volume: 23 Issue: special issue Pages: 53-58
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: This study was carried out to determine the effect of oral zinc supplementation on the growth of molarteeth and jaws on growing rat.Materials and methods: Fifteen western albino pregnant rats subjected to zinc deficiency diet from time of 16th ofgestation till day 21 postnatal days. Oral Zinc supplement in different dose (o.25 and o.5 mg) were added to thenormal zinc diet of the mothers from one day to 21 day postnatal periods). Neonate rats were sacrificed at thefollowings postnatal periods ( 7, 10, 14, 18 and21 day) .Histological evaluation for the development of 1st molar toothwith development of the jaws were estimated under light microscope .In addition ,serum zinc level in all studiedperiods were determined with atomic absorption spectrophotometer.Results: Histological examination for experimental group(0.5) showed acceleration in the growth of molar teeth andthe bones of the maxilla and mandible illustrates in early apposition of dental hard tissue and bone trabeculea.Declination in zinc levels were observed approximately in all studied groups with the increment of the period of thegrowth.Conclusion: This study was illustrated that there are obvious effects of oral supplementing zinc on the growth of teethand jaws of the rat suffered from zinc deficiency in gestation period and ameloblast showed to be the most affecteddental cells

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