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Article
Possible Role of Biological Agent on Characteristics of Sperm in Patients with Spondiloarthritis

Author: Atta AH. Mousa
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2015 Volume: 8 Issue: 1 Pages: 44-48
Publisher: Diyala University جامعة ديالى

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Abstract

Background: The role of TNF-α and TNF-α antagonists on seminal fluid parameters in men is controversial. TNF-α is a cytokine had a wide range of cellular effects. In testis, “TNF-α is produced by germ cells and it has a role in the regulation of spermatogenesis”. Objective: to study the effect of biological agent on sperm quality in a group of spondyloarthritis patients Patients and Methods: A prospective study was carried out in Baghdad teaching hospital during the period starting on 1st of January 2013 till the end of October 2013 .All semen samples of (60) spondyloarthritis patients and controls (60) was collected by masturbation after (72) hour of sexual abstinence. The semen samples was examined with regard to sperm concentration, motility, and morphology, according to WHO 1999 guidelines.. Results were compared with controlsResults: According semen parameters such as Volume, PH, Count, Motility Morphology in two groups of spondyloarthritis there were no significant differences noticed between TNF blocking agents and semen parameters when compared to controls group on( baseline ) but after (40 weeks), Regarding motility and morphology significant differences (P<0.001) were found between cases and healthy controls.Conclusion: Biological agents (infliximab&enbrel) had no affect on seminal fluid parameters such as volume, PH and sperm concentration, but it decreased motility of sperm and percent of normal morphology

Keywords

Sperm --- Biological agent --- Semen --- arthritis --- TNF


Article
Assessment of Weight Gain Post Treatment with Biological Compounds among A Sample of Patients Attending Baghdad Teaching Hospital
تقييم زيادة الوزن بعد المعالجة بالمركبات الاحيائية لدى عينة من المرضى الوافدين الى مستشفى بغداد التعليمي

Author: Atta Ah mousa Al sarray عطى السراي
Journal: nursing national Iraqi specility المجلة العراقية الوطنية للعلوم التمريضية ISSN: 18122388 Year: 2016 Volume: 29 Issue: 1 Pages: 45-50
Publisher: Baghdad University جامعة بغداد

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Abstract

Objective: to evaluate the increase in weight after biological agents and the association of weight gain with the body mass index among a sample of patients attending Baghdad Teaching Hospital Methods: A prospective study is carried out in Baghdad teaching hospital biological units and outpatient clinic of rheumatology for a period of one year starting On April 2015 and ending on March 2016. 120 patients were included in the study 40 psoriatic arthritis .40 ankylosing spondylitis and 40 rheumatoid arthritis Results : The study findings indicate that significance differences are seen regarding weight gain and biological agents (Infliximab, Etanercept and Adalimumab after one year of follow up of patients with psoriatic arthritis rheumatoid arthritis, ankylosing spondylitis respectively ,highest percentage of weight gain was reported with inflximab and psoriatic arthritis with a mean differences of BMI and weight (7.34&12.85) respectively while lowest percentage of weight gain was reporter with Etanercept and Rheumatoid arthritis with a mean differences of BMI ant weight(5.94 &8.61) respectivelyRecommendations: The study recommends further studies on the relation between weight gain and biological therapies and how and why this medication causes this weight change and what can be done to explore the real reason for these increments in weight of patients

الهدف: تقيم زيادة الوزن بعد العلاج بالمركبات الاحيائية المنهجية : عبر دراسة مستقبلية اجريت في مستشفى بغداد التعليمي في وحدة العلاج بالمركبات الاحيائية والعيادة الاستشارية للمفاصل ولمدة سنة من الاول من نيسان 2015الى نهاية اذار 2016وكان العدد الكلي للمرضى 120 مريضا 40 مريضا مصابا بالتهاب المفاصل الصدفي الفعال و40مريضا مصابا بتشع المفاصل و40مريضا مصابا بالتهاب المفاصل الرثوي النتائج اشارت نتائج الدراسة الى وجود فروق معنوية في زيادة الوزن بعد العلاج بالمركبات الاحيائية انفليكسيماب وايتانرسبت واداليمامب بعد عام من العلاج لمرضى التهاب المفاصل الصدفي الفعال وتشمع المفاصل والتهاب المفاصل الرثوي على التوالي وان اعلى نسبة في زيادة الوزن وجدت عند انفليكسيماب والتهاب المفاصل الصدفي مع فرق المعدل لمؤشر كتلة الجسم والوزن (7.34-12.85) على التوالي بينما كانت اقل نسبة في زيادة الوزن وجدت عند اتانرسبت والتهاب المفاصل الرثوي مع فرق المعدل لمؤشر كتلة الجسم والوزن (5.95-8.61) على التوالي التوصيات:تقترح الدراسة اجراء المزيد من الدراسات حول العلاقة بين زيادة الوزن والعلاج بالمركبات الاحيائية وكيف ولماذا هذه الادوية تسبب تغيير في الوزن وماالذي يمكن فعله لاكتشاف السبب الحقيقي وراء هذه الزيادة في وزن المرضى


Article
Dyslipidemia and biological agents among a sample of patients attending Baghdad Teaching Hospital

Authors: Atta AH Mousa --- Ali Hussein --- Nazar Abdull Latif
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2016 Volume: 29 Issue: 3 Pages: 129-132
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Tumor necrosis factor-alpha (TNF-α) is a multifunctional pro-inflammatory cytokine that had a major role in the etio-pathogenesis of psoriasis and psoriatic arthritis, rheumatoid arthritis, inflammatory bowel disease (IBD), and other dermatologic and rheumatologic conditions. A new era in the treatment of rheumatic diseases began with the development of TNF-α-inhibitorsObjectives: To evaluate lipid profile changes after anti-TNF therapy in patients with psoriatic, rheumatoid arthritis and ankylosing spondylitis Patients & Methods: A prospective study included 90 patients presenting with ((30) Psoriatic arthritis, (30) ankylosing spondylitis (30) rheumatoid arthritis (who were treated with anti-TNF therapy (infliximab, rituxmab etanercept) and assessed during follow-up period after 6month of therapy.Results: Regarding (TC,TG, HDL and LDL) Significance differences(p<0.000) were seen after biological therapy with infliximab infusion in patients with psoriatic arthritis , The current study had Significance differences regarding TG and HDL after 6 month of treatment of rheumatoid arthritis patients with rituximab., Significance differences were seen regarding TG and LDL in ankylosing spodylitis patients treated with etanerceptConclusion: Significance differences were seen regarding lipid profile and antitumor necrosis factor alpha therapy regarding psoriatic ,Rheumatoid arthritis and ankylosing spondylitis


Article
Effect of anti-TNF- tumor necrosis factor therapy on lipid profile in a sample of patients attending Baghdad teaching hospital
تأثير مضادات عوامل نخر الورم على نسبة الدهون لدى عينة من المرضى الوافدين الى مستشفى بغداد التعليمي

Authors: Nazar Abdull Latif نزار عبد اللطيف --- Ali Hussein علي حسين --- Atta AH Mousa عطا عبد الحسين موسى
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2016 Volume: 29 Issue: 2 Pages: 16-20
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Anti-tumor necrosis factor drugs (biological agents) are a class of drugs that are used worldwide to treat inflammatory conditions “these drugs are able to reduce inflammation and stop disease progression”.Objectives: To evaluate lipid profile changes after anti-TNF therapy in patients with psoriatic, rheumatoid arthritis and ankylosing spondylitis Patients &methods: A prospective study included 90 patients presenting with 30 Psoriatic arthritis (n=30), ankylosing spondylitis (n=30) rheumatoid arthritis (n=30) who were treated with anti-TNF therapy (infliximab, rituxmab etanercept) and assessed during follow-up period after 6month of therapy.Results: Regarding lipid profile, significance differences (P<0.000) were seen after biological therapy with infliximab infusion in patients with psoriatic arthritis. The current study had significant differences regarding TG and HDL after 6 month of treatment of rheumatoid arthritis patients with rituximab., Significance differences were seen regarding TG and LDL in ankylosing spondylitis patients treated with etanerceptConclusion: Significance differences were seen regarding lipid profile and antitumor necrosis factor alpha therapy regarding psoriatic, Rheumatoid arthritis and ankylosing spondylitis

: ان مضادات عوامل نخر الورم (المركبات الاحيائية) وهي صنف من الادوية المستخدمة عالميا لعلاج حالات الالتهاب وهذه الادوية لها القدرة على معالجة الالتهاب وايقاف تطور المرضالهدف: لتقييم نسبة اعتلال الدهون بعد العلاج بالمركبات الاحيائية لدى عينة من مرضى التهاب المفاصل الصدفي والرثوي وتشمع المفاصل المرضى وطريقة العمل: عبر دراسة مستقبلية شملت 90 مريضا (30 التهاب المفاصل الصدفي 30التهاب المفاصل الرثوي و30 تشمع المفاصل) مع فترة متابعة لمدة ستة أشهر بعد العلاج بالمركبات الاحيائيةالنتائج: وجد هناك فرق ذو دلالة معنوية بنسبة الدهون (الكولسترول الكلي والدهون الثلاثية والدهون عالية الكثافة والدهون واطئة الكثافة) بعد العلاج بالمركبات الاحيائية لدى مرضى التهاب المفاصل الصدفي والرثوي وتشمع المفاصلالاستنتاج: وجد هناك فرق ذو دلالة معنوية بين نسبة اعتلال الدهون ومضادات عوامل نخر الورم نوع الفا لدى مرضى التهاب المفاصل الصدفي والرثوي وتشمع المفاصل


Article
Evaluation of Application of Quality Improvement Program Among a Samples of Primary Health Care Centers In Thi-qar Governorate
تقييم تطبيق برنامج تحسين الجودة لعينة من مراكز الرعاية الصحية الأولية في محافظة ذي قار

Author: Ameer .k. Resun AL-Awadii Dr. Atta AH. Mousa AL-Sarray د. أمير كاظم رسن د.عطا عبد الحسين موسى
Journal: Thi-Qar Medical Journal مجلة ذي قار الطبية ISSN: 19929218 Year: 2018 Volume: 15 Issue: 1 Pages: 12-28
Publisher: Thi-Qar University جامعة ذي قار

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Abstract

According to collected data finding the Quality evaluating percentage for administrative units 87.7% & it's main weak indicators were for feedback & it is records , administrative guideline , administrative training , infection control guideline , alcohol , waste's cart ,waste's balance & log documentation of some record . 83.1% evaluating percent for medical units and main weakness points were in numbers of medical &serving staff , gynecological examination room ,waiting & examination time .Pharmacy unit had 89.5% ,main weak indicators were in number of pharmacist ,separated area between boxes of drugs and walls , smoke detector , number of trundle , doses & rout of drugs on recipe .Tuberculosis program had 92.1% and weak score only in health promotion folder for tuberculosis disease ,following of dropout patient from therapy. There are weakness in all immunization coverage in most centers but Vitamin A , storage of vaccine , training of immunization team , presence of records , infection control equipments had good score in immunization units which had 81.1%. Maternal units had lowest evaluating percentage was 74.6 % because there are weak indicators in female medical staff , units according to standard , home visit , presence of sonar ,1st & 4th maternal visit coverage .Health promotion unit had 91.6% ,there are weak score for community participation , halls. While IMNCH units had 88.4% average percentage and most weak indicators were for number of medical staff , adequate place for ARI equipments program ,Thermometer. The continuous training & psychological health services had 82.6% , 95.8% respectively .Laboratory units evaluating percentage was 76.6% & most weak indicators were in structure staff , shaker , balance , spirit lamp , dispenser , calibration, KLB , G , AFB & water bath .In this study the main weak indicators regarding health visitor program in internal net work , transport vehicle , health visitor's maps & bags ,updating numbering of houses therefore this program had 84.4%. Weak indicators regarding hotel services were in rights & duties list of patient , Rumba & special toilets for handicapped patients ,alcohol , cleanliness of gardens therefore the hotel services had 80.3% .Dental services units had 83.6% ,itis weakness score were in number of dentist , dental devices , XR dental devices , processing devices , debris removal devices , optical filler material , activation of dentists , dykal , amalgam , temporary filler material ,XR films & batting root .Emergency services units had 83.7% evaluating percent .While most weak scores regarding emergency services were for medical staff , laundry & serving staff .

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