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Article
Correlation between crevicular C-reactive protein level with its serum level in chronic periodontitis patients

Author: Basima Gh. Ali
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2014 Volume: 26 Issue: 3 Pages: 84-88
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: The main purpose of this study is to find if there is any correlation between the level of C-reactiveprotein (CRP) in gingival crevicular fluid with its serum level in chronic periodontitis patients and to explore thedifferences between them according to the probing depth.Materials and methods: Forty seven male subjects enrolled in this study. Thirty males with chronic periodontitisconsidered as study group whom further subdivided according to probing depth into subgroup 1 with pocket depth≤6mm, subgroup 2 with pocket depth >6mm. The other 17 subjects considered as controls. For all subjects, clinicalexamination where done for periodontal parameters plaque index (PLI), gingival index (GI), bleeding on probing(BOP), probing pocket depth (PPD) and clinical attachment level (CAL). The gingival crevicular fluid (GCF) werecollected using filter paper size 30 from gingival sulcus of the controls and from (138) pocket site (75 sites > 6mm. and63 ≤ 6mm.). The weight of the GCF was measured by reading the difference in the weight of filter paper before andafter absorption of GCF. Crevicular level of CRP was measured calorimetrically. The serum level CRP was measuredusing latex test.Results: Highly significant difference in the weight of GCF, crevicular and serum level of CRP between chronicperiodontitis and control groups. Subgroup 2 got higher scores of weight of GCF and positive record of crevicularand serum CRP compared with subgroup 1 with a non-significant difference. A highly significant difference in thenumber of sites with positive crevicular and serum CRP compared to the negative number between chronicperiodontitis and control groups also between subgroup1 and subgroup 2.Weight of GCF gets a negative significant correlation with GI at control group and subgroup2. Serum level of CRPexhibits a negative significant correlation with PLI for chronic periodontitis and control group and positive significantcorrelation for GI at subgroup 1. The crevicular CRP get significant negative correlation with GI of subgroup 1.Conclusions: Crevicular fluid is very good marker for the degree of inflammation of the periodontal pocket. Thecrevicular level of CRP may be considered as a good tool for estimating the systemic effect and predictor for theeffect of periodontitis on the general health and the correlation of crevicular with serum CRP aid to high light thiseffect.

الھدف الرئیسي من ھذه الدراسة ھو معرفة تركیز البروتین الارتكاسي في السائل اللثوي ومقارنتھ مع تركیزه في مصل دم مرضى النسغاغ المزمن بالمقارنة معالمجموعة الضابطة ایضا تحاول الدراسة ایجاد علاقات بین تلك التراكیز ومؤشرات ماحول الاسنان السریریة في مجموعة الدراسة والمجموعة الضابطة. توصلتالدراسة الى انھ ھناك فرق واضح في التراكیز بین كلا المجموعتین وكذلك فان مستوى البروتین الارتكاسي یختلف باختلاف شدة الاصابة بمرض النساغ المزمنوخلصت الدراسة الى ان مرضالنساغ المزمن مع مؤشراتھ المناعیة قد یعكس صورة تاثیر ھذا المرضعلى الصحة العامة


Article
Salivary antioxidants and nutritional status among chronic periodontitis patients

Authors: Basima Gh. Ali --- Samer S. Jaafer
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2011 Volume: 23 Issue: 1 Pages: 58-62
Publisher: Baghdad University جامعة بغداد

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Abstract

ABSTRACT
Background: Chronic periodontitis is an inflammatory disease that affects the supporting tissues of the teeth.
Malnutrition, particularly characterized by deficiencies of the essential necessary antioxidants micronutrients
including vitamins (C, E and A), which they had a significant effects in relation to oral health. The aims of this study
were to assess the salivary antioxidants vitamins (C, E and A) levels and their relation to periodontal parameter
among individuals with underweight and normal weight
Materials and Methods: The sample is consist from 80 males with age group (25-50) years old without any systemic
disease and divided into 4 groups: group 1 (20) individuals had underweight and chronic periodontitis, group 2 (20)
individuals had underweight and normal periodontium, group 3 (20) individuals had normal weight and chronic
periodontitis and group 4 (20) individuals had normal weight and normal periodontium. Nutritional status was
assessed by body mass index (BMI). Periodontal parameters used in this study were probing pocket depth (PPD) and
clinical attachment level (CAL). Unstimulated salivary samples were collected and then chemically analyzed.
Results: The salivary levels of vitamins were significantly lower in the groups of underweight in compare with the
group of normal weight and normal periodontium. For the group with (N.W. & CH.Perio.) the salivary levels of vitamins
C and A was significantly lower in compare with the group (N.W. & N.Perio.), For probing pocket depth, vitamin C
had a negative significant correlation with PPD≥7, vitamin A also had a negative significant with PPD≥7 and PPD≤6.
Concerning clinical attachment level vitamin E had a positive significant correlation with CAL≥6; vitamin A had a
negative significant with CAL≤5.
Conclusions: Periodontal disease revealed a higher occurrence and severity among individuals with malnutrition
therefore good nutrition and special oral health care are needed for them.
Key words: chronic periodontitis, antioxidants, nutritional status, body mass index. (J Bagh Coll Dentistry 2011;23(1):58-
62).

Keywords


Article
Is A Chronic Periodontitis Patient Likely To Be An ABO Secretor

Author: Basima GH.Ali باسمة غفوري علي
Journal: Tikrit Journal for Dental Sciences مجلة تكريت لعلوم طب الاسنان ISSN: 20731213 Year: 2016 Volume: 4 Issue: 2 Pages: 136-140
Publisher: Tikrit University جامعة تكريت

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Abstract

Chronic periodontitis is the most prevalent oral inflammatorydisease that affect teeth supporting tissues in response to microbialinfection. A secretor is aterm applied to anyone who secret his/herblood type antigen into their body fluids as saliva in the oralcavity. Forty eight males were participated in the present research.Their age ranging from 35 to 55 years. The clinical periodontalparameters included Plaque index (PLI), Gingival index (GI),bleeding on probing (BOP) and Probing pocket depth (PPD) wereexamined also. .The secretory ABO blood groups from saliva byusing Blood Typing Kit # 11 were assessed. After that the patientswere divided into secretors and non-secretors and the comparisonswere done between them. There was highly significance differencebetween secretory and non-secretory chronic periodontitis patientsin all periodontal parameters (PI, GI and PPD), from the totalsample the Proportional ratio for secretory chronic periodontitisgroup was 58.33% while the proportional ratio for the nonsecretarychronic periodontitis was 41.66%. Group O is thepredominant type of ABO for both groups. Chronic periodontitis ismore likely to occur in secretor ABO more than non-secretorABO.


Article
Serum Level of TNF-α and IL-17 in Patient Have Chronic Periodontitis Associated Rheumatoid Arthritis

Authors: Munir Nasr Hamed, منير نصر حامد --- Basima Gh. Ali
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2017 Volume: 29 Issue: 1 Pages: 104-110
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: chronic periodontitis and rheumatoid arthritis are widely prevalent diseases and are characterized by tissue destruction due to chronic inflammation. Recently, there is growing evidence that the two diseases share many pathological features the aims of the study To determine the periodontal health status in patient have chronic periodontitis with rheumatoid arthritis and compare it with those having chronic periodontitis without Rheumatoid arthritis and determine the serum levels of interleukin -17(IL-17), tumor necrosis factor- alpha (TNF-α ) in both groups and compare with the control group (subject samples neither have periodontitis nor arthritis ) and correlate these immunological markers with the periodontal parameters Plaque index , gingival index , bleeding on probing, probing depth, clinical attachment level and number of missing teeth.Materials and methods: Eighty (80) males and females subjects with age range (30-45) years were recruited in this study they were divided into three main groups The chronic periodontitis with rheumatoid arthritis group consist of thirty (30) subjects and second group consist of thirty (30) subjects have chronic periodontitis and third group consist of twenty (20) subject case control group. All subjects had normal weight and height range according to BMI (body mass index) that it value is (18.5-25), Clinical periodontal parameters used in this study were Plaque index, gingival index, bleeding on probing, clinical attachment level index, probing pocket depth and number of missing teeth was measured in all groups at four surfaces of all presented teeth Blood samples were collected from all individuals and examined to determined serum level of interleukin -17 and tumor necrosis factor-a by mean of enzyme-linked immune–sorbent assay.Results: The present study showed patients with chronic periodontitis and rheumatoid arthritis had higher prevalence of sites presenting dental plaque, a higher rate of gingival inflammation and bleeding on probing greater probing depth, greater attachment loss and high number of missing teeth compared to those had chronic periodontitis only and control subjects . Also highly significant differences between studied group regarding serum level of IL-17 and TNF-α atp < 0.001, as well as, it revealed that mean serum levels of IL-17 were statistically higher in chronic periodontitis with rheumatoid arthritis group (607.9 ± 79.9) than Chronic Periodontitis group (421.4 ± 5.9) and Control groups (15.9 ± 2.7) similarly serum level of TNF-α (402.2 ± 41.2 319.4 ± 526 85.3 ± 4.9) respectively at p < 0.001. Regarding correlation, the current study observed strong positive correlation between serum levels of IL-17 andTNF-α with PL.I, GI, BOP, PPD CAL and the number of missing teeth in the PRA at p<0.001. Also this study reveal significant correlation between the two immunological markers (TNF-α and IL-17) in chronic periodontitis with rheumatoid arthritis group and in Chronic Periodontitis group.Conclusion: It was concluded that there was higher potentiality to chronic periodontitis involvement among rheumatoid arthritis patients, that correlated positively with increase the level of serum levels of IL-17 and TNF-α accordingly with high score of clinical parameters that had recorded. That mean TNF –a and IL-17 may play an important role in increase the severity of periodontitis as well as rheumatoid arthritis


Article
Bacteriological Findings within Internal Implant Hole Following Flapless Implant Placement

Authors: Abbas S.AL-Mizraqchi --- Basima GH. Ali --- Khudair Ali Abd
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2018 Volume: 30 Issue: 3 Pages: 13-16
Publisher: Baghdad University جامعة بغداد

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Abstract

Back ground: Microbial penetration inside the implant's internal hole creates a bacterial reservoir that is related with an area of inflamed connective tissue opposite the fixture-abutment junction and this can affect the health of the peri-implant tissue.Aims of the study: Evaluate the types aerobic and anaerobic bacterial count-percentage and difference between Aerobic and Anaerobic microflora in the implant screw hole three months after implant placement. Monitor the periodontal health status of all patients, throughout the study.Material and methods: Study methodology; Eight partially edentulous patients received 20 dental implants and these implants done with flapless surgical procedure. All patients examined clinically to determined their oral health status by examination of their plaque index, Gingival index and Bleeding on probing, each two weeks for 90 days (8visits) throughout the study period. Three months after that, the plaque sample collected from the internal hole of fixture and transfer to bacterial investigation and assessment the amount of anaerobic and aerobic bacteria.Results: Although the anaerobic viable count is higher than that of aerobic, but with statistically not significant difference between those counts (P>0.05).


Article
Detection of salivary flow rate and minerals in smokers and non smokers with chronic periodontitis (Clinical and Biochemical study)

Authors: Basima Gh. Ali باسمة علي --- Omar Husham Ali عمر هشام علي
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2012 Volume: 24 Issue: 1 Pages: 68-71
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Chronic periodontitis is an inflammatory disease that affects the supporting tissues of the teeth and it’s acommon chronic adult condition. Smoking is considering a major risk factor for development and progression ofperiodontal disease, and it has an effect to the salivary minerals which cooperate with plaque and calculusinitiation, maturation, and metabolism with periodontal disease formation. The purpose of this study was to evaluatethe effect of smoking on the salivary minerals in subjects with chronic periodontitis compared to healthy subjects bybiochemical analysis of these minerals. .Materials and methods: The study group included 75 males–25 males smokers with chronic periodontitis (G1), 25males non-smokers with chronic periodontitis (G2) and 25 males non smokers with healthy periodontium (G3). All withan age rang 30-40 years. Clinical measurements include (PLI, BOP, PPD, CAL) were determined for each toothexcept third molar. Unstimulated whole saliva was collected. PH and salivary flow rate (SFR) were obtained and thelevels of five elements–sodium, potassium, calcium, magnesium, and phosphate in each specimen were analyzed.Results: A highly significant difference in PLI in (G1) group than in (G3) group and a non significant in (G1) group than(G2) group. A highly significant relation of gingival bleeding on probing in (G2) group in compared to (G1) groupwith very clearly marked decrease in the total sites that bleed in smokers than non-smokers. Significant differences inPPD and CAL were found between (G1) group and (G2) group. The results of this study for salivary minerals showedthat there were high significant differences between (G1) group and (G2) group for Ca+2, Na+1 and K+1 ions andbetween (G1) group and (G3) group for Ca+2, Na+1, K+1 and Po4-3 ions while significant differences were found in (G1)group compared with the other groups for Mg+2 ion. Salivary flow rate was significantly higher in (G1) groupcompared with the other groups. A significant increase in PH level in (G1) group compared to (G3). In (G1) group,there was a significant positive correlation between the mean level of Ca+2 and PLI. There was also a significantnegative correlation between the mean level of Po4-3 and CAL.Conclusions: The researcher could conclude that monitoring for changes in salivary composition might be a usefultool to detect the effect of smoking on periodontal health status.


Article
Early detection of periodontitis among young adult cigarette smokers and non-smokers using cone beam computed tomography

Authors: Maisam A. Kadhem ميسم كاظم --- Basima GH. Ali باسمه علي --- Shifa H. Al-Naimi شفاء النعيمي
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2014 Volume: 26 Issue: 2 Pages: 116-121
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Periodontitis is an inflammatory disease that affects the supporting tissues of the teeth; Smoking is animportant risk factor for periodontitis induces alveolar bone loss and cause an imbalance between bone resorptionand bone deposition. The purpose of this study is to detect and compare the presence of incipient periodontitisamong young smokers and non-smokers by measuring the distance between cement-enamel junction and alveolarcrest (CEJ-Ac) using Cone Beam Computed Tomography (CBCT).Material and methods: The total sample composed of fifty two participants, thirty one smokers and twenty one nonsmokers(age range 14-22 years). Periodontal parameters: plaque index (PLI), gingival index (GI) were recorded forall teeth except the third molar while the radiographic analysis using CBCT was recorded on the Ramfjord teeth, theunit of measurement was from cement-enamel junction to alveolar crest distance (CEJ-Ac distance) per site inmillimeters.Results: The results obtained were a non significant difference for PLI, a significant difference of mean of GI betweenyoung smokers and non smokers. There was a highly significant difference in the general mean of CEJ-Ac distancebetween both groups. There was a significant difference between maxillary and mandibular teeth, a non significantdifference between right and left sides among young smokers and non smokers.Conclusion: The CBCT device plays an important role in detection the incipient form of periodontitis among youngsmokers and non-smokers, so we concluded that there is a highly significant difference in the general mean CEJ-Acdistance between young smokers and non smokers with increase distance in the maxillary teeth than that in themandibular teeth


Article
Quantitative detection and correlation of Epstein - Barr Virus in plasma with gingivitis and severity of chronic periodontitis by using real-time polymerase chain reaction technique

Authors: Nada K. Imran ندى كاظم عمران --- Basima Gh. Ali --- Duraid Q. Jassim
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2014 Volume: 26 Issue: 4 Pages: 133-140
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: This study aimed to detect EBV quantitatively in plasma using real-time polymerase chain reactiontechnique in chronic periodontitis and gingivitis patients and to compare the finding with control subjects (healthyperiodontium) and to investigate the relationship between the presence of EBV & the severity of periodontaldiseases using the clinical periodontal parameters (PLI ,GI , BOP ,PPD and CAL) between each of (chronicperiodontitis and gingivitis) patients and compare with control (healthy periodontium) subjects .Materials and methods: The study sample consisted of (101) individual of both genders, (61) chronic periodontitispatients which were subdivided into (mild, moderate & severe) depending on the scores of clinical attachmentlevel, (20) gingivitis patients and (20) control subjects (healthy periodontium) with age ranged from (30-50) years. Allthe groups were without any history of systemic diseases. Clinical periodontal parameters used in this study were (PLI,GI , BOP ,PPD and CAL) .Blood samples were collected from all individuals and examined by Real-Time PCRtechnique for the detection of EBV.Results: The result of comparison for the occurrence of EBV among study and control groups according to sequentialresponding of EBV appears to be highly significant at negative level of EBV, significant in (100 - 500 copy/105 cells)level and the results of leftover levels appear non significant difference. The result of correlation between the actualoccurrence of EBV and PPD scores in severe chronic periodontitis subgroup appears to be significant at PPD score(1) and non significant at scores (2&3). The correlations between EBV and PPD scores in moderate and mild chronicperiodontitis subgroups appear to be non significant with all scores. The results of correlation between EBV and CALparameter appear to be non significant among all scores of chronic periodontitis subgroup. Concerning plaqueindex, the correlation appears to be significant in mild chronic periodonttis subgroup and highly significant in controlgroup. In case of gingival index, the correlation appears to be significant in severe chronic periodontitis subgroupand control group .The result of correlation with (B.O.P. score 1) appears to be highly significant in severe subgroup ofchronic periodontitis group and significant in gingivitis group, while in case of (B.O.P. score 0), the correlationappears to be significant only in severe chronic periodonttis subgroup.Conclusions: The present findings revealed that there may be an association between EBV infection and the severityof periodontal diseases and thus coinfection with EBV may play a role in increase destruction of periodontal tissues


Article
Detection of Granulocyte Chemotactic Protein 2 in Serum of Periodontitis Patients

Authors: Saja GH. Hussien سجى حسين --- Basima Gh. Ali باسمة غفوري علي
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2016 Volume: 28 Issue: 4 Pages: 122-127
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Chronic periodontitis defined as “an infectious inflammatory disease within supporting tissues of the teeth, progressive attachment loss and bone loss". Aggressive periodontitis is rare which in most cases manifest themselves clinically during youth. It characterized by rapid rate of disease progression .Pro-inflammatory chemokines organized inflammatory responses. Granulocyte chemotactic protein 2 is involved in neutrophil gathering and movement. The purpose of the study is to detect serum of Granulocyte Chemotactic Protein 2 and correlate to periodontal condition in patients with chronic periodontitis, Aggressive periodontitis and Healthy Control subjects and measurement the count of neutrophils for the studied groups.Subjects and methods: Eighty four male and female were enrolled in this study .They were divided into three groups (18) patients with Aggressive periodontitis with age range (20-45) years, (33) chronic periodontitis patients and (33) Healthy control with an age range (30-50). Clinical periodontal parameters were recorded for each group. The concentration of granulocyte chemotactic protein- 2 in serum was quantified by a high-sensitivity enzyme linked immunosorbent assay. Blood neutrophils count were detect for five subjects from each group using light microscopeResult: ANOVA analysis revealed high significant differences in Granulocyte chemotactic protein 2 means between aggressive, chronic and controls. Neutrophils count in aggressive periodontitis is higher than chronic and controls .No significant difference in neutrophils count between aggressive and chronic periodontitis, while significant difference when correlate them with controlsConclusion The concentration of granulocyte chemotactic protein 2 increased with the increase in severity of periodontitis. Higher neutrophils count was found in aggressive periodontitis than chronic and controls. As higher granulocyte chemotactic protein 2 that chemoattract more neutrophils recruitment to the site of inflammation


Article
Effects of light smoking on salivary levels of alkaline phosphatase and osteocalcin in chronic periodontitis patients

Authors: Lubaba A. Abdul Ameer لبابة عبد الامير --- Basima Gh. Ali باسمة غفوري علي
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2015 Volume: 27 Issue: 2 Pages: 110-114
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Chronic periodontitis is an inflammatory disease that affects the supporting tissues of the teeth and it’scommon among adults. Smoking is an important risk factor for periodontitis induces alveolar bone loss. Alkalinephosphatase enzyme is involved in the destruction of the human periodontium. It is produced by many cells such aspolymorphonuclear leukocytes, osteoblasts, macrophages and fibroblasts within the area of the periodontium andgingival crevice. Osteocalcin is one of the most abundant matrix proteins found in bones and the only matrix proteinsynthesized exclusively there. Smaller Osteocalcin fragments are found in areas of bone remodeling and are actuallydegradation products of the bone matrix.The purpose of this study was to evaluatethe effect of smoking on thesalivary alkaline phosphatase and Osteocalcin in subjects with chronic periodontitis compared to control subjects.Materials and Methods: Five ml of unstimulated whole saliva samples and full-mouth clinical periodontal recordings(plaque index, gingival index, bleeding on probing, probing pocket depth and clinical attachment level) wereobtained from study groups (25 light smokers and 33 non-smokerssubjects, both with chronic periodontitis) andcontrol groups (8 light smokers and 13 non-smokers subjects, both with healthy periodontium). All subjects weresystemically healthy males, with age range (30-50) years. Salivary Alkaline phosphatase and Osteocalcin levels weredetermined by Colorimetric and Enzyme-linked Immunosorbent Assays, respectively.Results: Smoker chronic periodontitis patients revealed non-significant differences in clinical periodontal parameterswith non-smoker counterparts (P o.o5) in terms of Plaque index, Probing pocket depth and Clinical attachment loss,with slight increase in plaque index value in smoker chronic periodontitis group(1.42±0.46) than non-smoker chronicperiodontitis group, while there were highly significant differences in terms of Gingival index and Bleeding onprobing(P ≤ 0.01).Osteocalcin levels were lower in smoker chronic periodontitis group (0.13±0.20) than non-smokerchronic periodontitis group (1.09±2.26) with significant difference (0.05 ≥ P > 0.01). Mean of Alkaline phosphataselevel was lower in smoker chronic periodontitis (11.14±4.53) than non-smoker chronic periodontitis (11.45±4.17) with anon-significant difference, while there was a significant difference inAlkaline phosphatase concentrations betweensmoker and non-smoker control groups.There were non-significant differences between smoker chronic periodontitisand smoker control groups in terms of Osteocalcin and Alkaline phosphatase concentrations. There were nonsignificantdifferences between non-smoker chronic periodontitis and non-smoker control groups in terms ofOsteocalcin and Alkaline phosphatase concentrations.Conclusion: Within the limits of this study, it may be suggested that suppression of salivary Osteocalcin levels bysmoking and slight increase in alkaline phosphatase in smokers groups, may explain the deleterious effects ofsmoking on periodontal health status.

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