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Article
Treatment of Plane Warts by Topical Trichloroacetic Acid with Two Concentration (35% & 70% ); A Comparative Therapeutic Study

Author: Basman Medhat fadheel, Yusif Aldabouni
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2019 Volume: 18 Issue: 3 Pages: 255-259
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

BACKGROUND:Plane warts represents a common dermatological problem and self-limiting viral infection of theskin caused by human papilloma viruses type (3,10,28,29) with no uniformly effective treatmentmodality.OBJECTIVE:To evaluate and compare the effectiveness and side effect of topical trichloroacetic acid solution intwo concentration (35% & 70%) for treatment of plane warts.PATIENTS AND METHODSThis is a comparative interventional therapeutic study conducted at the dermatology center ofBaghdad Teaching Hospital / Medical City . Sixty consecutive patients with plane warts wererandomly assigned into two groups of thirty patients each; group A received topical trichloroaceticacid 35% (9 patients defaulted for unknown reasons) and group B received topical trichloroaceticacid 70% (8 patients defaulted for unknown reasons) once weekly application by doctor at hospitalwith wood stick once weekly until complete responce of the lesions or for at least four weeks.Patients with complete response follow up monthly for 3 months for detecting recurrence.RESULTS:In group (A) 9 (42.85 %) patients from showed complete response, with 9 (42.85 %) patientsshowed partial response; the remaining 3 (14.28%) patients showed no response (p value ˂ 0.05)with complete response (7 from 9) need 4-8 weeks of treatment, while in group (B) 13 (59.09 %)patients showed complete response, with 8 (36.36 %) patients showed partial response; theremaining one (4.54 %) patients showed no response, (p value < 0.05) with complete response (8from 13) need two to four weeks of treatment i.e TCA 70% faster response. Most of patient sufferfrom burning sensation & itching as a side effects and few patients with erythema &dyspigmentaion. There are 2 (9.52%) recurrent cases from group 35% with 1 (4.54%) recurrent casein group 70% .CONCLUSION:both concentrations

Keywords

plane wart --- TCA


Article
Effect of the Biological Drug Etanercept on Tumor necrosis factor-α Levels in Psoriatic Patients

Authors: Basman Medhat Fadheel --- Ban Noori Al-Qadhi --- Rasha Hussain Kuba
Journal: Iraqi Journal of Science المجلة العراقية للعلوم ISSN: 00672904/23121637 Year: 2018 Volume: 59 Issue: 2C Pages: 998-1005
Publisher: Baghdad University جامعة بغداد

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Abstract

Psoriasis is a common, chronic, immune mediated disorder.The disease is arising as a result of dysregulated interactions of the innate and adaptive immune system in the context of skin epithelium and connective tissue. The biological drug Etanercept(ETN) approved for use in treated psoriasis. ETN is tumor necrosis factor- α (TNF-α) inhibitor. In this study, 48 psoriatic patients were taken before and after treatment who attended to the Dermatology and Venereology Department in Baghdad Teaching Hospital during the period from December 2016 to September 2017and 50 samples were used as healthy control group. The results showed that most psoriatic patients 52.08 % were within the second and third decades 20-35 year, and the majority of psoriatic patients were males 62.5% and the ratio of male to female is 1.67:1. Moreover, the results demonstrated that the males were more expected psoriasis compare with females. Blood samples were collected and TNF- α was estimated in sera of all subjects by using Enzyme Linked Immunosorbent Assay (ELISA). The TNF- α mean levels in psoriatic patients before treatment was 189.5±26.0 ng/ml, and after treatment was 223.6±41.1 ng/ml compar with the healthy control group 93.5±2.4 ng/ml. The results showed significant differences between the studied groups

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