research centers


Search results: Found 1

Listing 1 - 1 of 1
Sort by

Article
Effect of ferulic acid on Myocardial Ischemia/Reperfusion Injury In Male Mice.

Authors: Bassim I. Mohammad AL-Sheibani --- Najah Raiesh Hadi --- Najwan Abdulameer Atia --- Fadhil Ghaly. Yousif
Journal: Kufa Journal For Veterinary Medical Sciences مجلة الكوفة للعلوم الطبية البيطرية ISSN: 20779798 Year: 2014 Volume: 5 Issue: 2 Pages: 282-294
Publisher: University of Kufa جامعة الكوفة

Loading...
Loading...
Abstract

Myocardial ischemia–reperfusion represents a clinically relevant problem associated with thrombolysis, angioplasty and coronary bypass surgery. Injury of myocardium due to ischemia–reperfusion includes cardiac contractile dysfunction, arrhythmias as well as irreversible myocytes damage. A total of 24 Swiss albino adult male mice were randomized into 4 equal groups. Group (1) sham group; Group (2) control group; Group (3) control vehicle (DMSO) group; Group (4) Ferulic acid treated group. Results of this study showed that levels of myocardial IL-6, were increased (p<0.001) in the control group. Histologically, all mice in control group showed significant cardiac injury (p<0.001). Ferulic acid significantly counteract the increase in myocardium level of IL-6 (P < 0.001). Histological analysis revealed that ferulic acid markedly reduced (P < 0.001) the severity of cardiac injury in the mice underwent LAD ligation procedure.

Listing 1 - 1 of 1
Sort by
Narrow your search

Resource type

article (1)


Language

English (1)


Year
From To Submit

2014 (1)