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Evaluation the antioxidant effect of α-L- Fucose injection into rabbit periodontium

Authors: Chenar A. Mohammad --- Khlood A. Al-Safi خلود الصافي --- Bakhtiar M. Ahmed
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2013 Volume: 25 Issue: 2 Pages: 119-124
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: α-L-Fucose is a methyl pentose sugar similar to L-galactose except for the loss of alcohol group oncarbon number 6. The objective of this study is to evaluate the biochemical and antioxidant effect of intracrevicularinjection of fucose into rabbits periodontium, throughout measuring the levels of total protein (TP), total fucose (TF),protein bound fucose PBF) , Malondialdehyde (MDA) , and vitamin C in sera of fucose injected rabbit groups.(Materials and Methods: The existing study was carried out on 55 male rabbits and were divided randomly into threegroups ; first group was injected with 50μl of 150mM fucose solution into gingival sulcus ; second group was injectedwith 50 μl of normal saline ; while the third group was not received any injection ( normal group) .Blood sampleswere collected from injected groups at time intervals of 1, 3 ,24 ,72, and 168 hours after injection, for measuring ofserum TP, TF, , PBF , MDA, and vitamin C and compared with normal group.Results: The results showed a significant increase in the mean concentration of TF and PBF reaching its maximumvalue 3hrs after injection, then it decline until reached its normal value 168 hours after injection, whereas serum totalprotein increased significantly only 3 hours after injection. Also serum MDA level did not change after injection, whileserum vitamin C increased immediately after fucose injection, even 72 hours after injection.Conclusion: Intracrevicular injection of α-L- Fucose has an observable effect on TF and PBF this may give anindication about its effect on periodontal tissue and has a role in the body defence against oxidative stress,throughout increasing the production of vitamin C.


Article
The effect of intracrevicular injection of fucose on serum interlukine -1beta and tumor necrosis factor alpha

Authors: Chenar A. Mohammad --- Khlood A. Al-Safi خلود الصافي --- Bakhtiar M. Ahmed
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2013 Volume: 25 Issue: 2 Pages: 125-129
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: α-L-Fucose is a methyl pentose sugar, had the ability to kill bacteria, controlling infection and normalizeimmune function. The objective of this study is to determine the effect of sulcular injection of fucose on rabbitsperiodontium , throughout measuring the level of some proinflammatory cytokine ; interlukine 1beta ( IL-1beta) andtumor necrosis factor ( TNF-alpha) in sera of rabbits before fucose injection and at 3 days after fucose injection.Materials and Methods: The study was carried on using ( 20 ) male rabbits of the same species weighted (1-1.5 kg ) ,the blood samples were collected from hearts of 20 rabbits before fucose injection and consider as( non injectedgroup) , and after 3 days of fucose injection and consider as (fucose injected group) and analyzed fordetermination of the concentration of IL-1ß and TNF-α.Results: The results showed a highly significant decrease in the mean concentration of TNF-α in sera of fucoseinjected group(19.05± 1.166) pg ⁄ml when compared to its mean concentration in non injected group (27.25±7.371)pg ⁄ml ,also a highly significant decrease in the mean concentration of IL-1ß in sera of fucose injected group(34.19 ±3.1)pg ⁄ml as compared to its mean concentration in sera of non injected group (38.86 ±4.565)pg⁄ml.Conclusion: both proinflammatory cytokines were influenced and inhibited by local fucose injection

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