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A comparison of the prevalence of anti-Liver/Kidney Microsome antibody type-1(LKM-1) in individuals with chronic hepatitis C and those with autoimmune hepatitis

Author: Eman Sh. AL- Obeidy* M.Sc د. ايمان شاكر العبيدي
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 / 24108057 Year: 2007 Volume: 49 Issue: 2 Pages: 245-248
Publisher: Baghdad University جامعة بغداد

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Abstract

Summary:Background: Autoantibodies are frequently found in patients with chronic hepatitis C, which suggests that HCV elicit an immune response in the host. ). The relationship of type-2 AIH to chronic hepatitis C (HCV) is an interesting and as yet unresolved problem. Importantly, antibodies to liver/kidney microsome type-1 (LKM1), the serologic marker of type 2-AIH, have been recognized in serum of some patients with chronic hepatitis C . Methods: Anti-liver kidney microsome type 1 (LKM-1) autoantibodies were studied by indirect immuno florescence assay (IIF) and confirmed by immunoblot in the serum of 73 Iraqi patients with autoimmune hepatitis (AIH) in comparison with 50 patients control (HCV infection) and 50 healthy individuals.Results: anti-LKM 1 with high titers (1/160) present in serum of all patients with AIH-2, whereas they present in titer (≤1/80) in serum of 19 patients with chronic HCV, while all healthy control group are negative.Conclusion: AIH is easily distinguished from chronic viral hepatitis since patients with AIH are more commonly women than those with chronic viral hepatitis, and they have higher serum levels of aspartate aminotransferase, bilirubin, gamma-globulin, IgG, alkaline phosphates, and higher frequency of multilobular necrosis on histologic examination than counters with chronic viral hepatitis. Keywords: HCV, AIH, , IgG

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: HCV --- AIH --- IgG


Article
C3 and C4 complement components in autoimmune hepatitis.

Author: Eman Sh. AL-Obeidy M.Sc. د. ايمان شاكر العبيدي
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 / 24108057 Year: 2007 Volume: 49 Issue: 3 Pages: 331-333
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: . Autoimmune hepatitis (AIH) is an unresolving inflammation of the liver of unknown cause associated with interface hepatitis on histological examination,hypergammaglobulinemia and presence of circulating autoantibodies. Antibody-mediated tissue injury might be responsible for tissue injury in AIH therefore; a number of studies have been focused on the complement system in these patients .The aim of the study is to estimate the level of complement (C3 and C4) in different types of Autoimmune hepatitis (AIH).Methods: The study M’as performed on 73 Iraqi patients with autoimmune hepatitis (AIH), attending the teaching hospital for gastroenterology and liver disease in a period betM'een November 2003 and July 2004. : Anti- soluble liver ANA , SAM,LKA1-1 ,and LC-1 Abs were detected using Enzyme-Linked Immunosorbent Assay (ELISA) technique . Anti-SLA/LP was detected using the Euroline method.Quantitation of serum C3 and C4 of the study groups were carried by single radial immudiffusion (SRID) test. Equal volumeResults: Significant differences M’as observed between AIH patients and healthy control group in the mean level of C3 and C4. In addition, level of C4 in the sera of patients with type 2 was lower than those of type 1 and 3.Conclusion:It M’as conclude that patients with MH do not have abnormal catabolism of complement or increased level of cleavage products of C3, whereas, the depression of complement level may reflect decreased hepatic synthesis.

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