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Evaluation of the Effect of Dapagliflozin on Atherosclerosis Progression by Interfering with Inflammatory and Oxidative Stress Pathways in Rabbits

Author: Hajir Karim Abd-Ulhussein, Fadhil Abdul‑Jabbar Rizij
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2019 Volume: 16 Issue: 1 Pages: 20-24
Publisher: Babylon University جامعة بابل

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Abstract

Background: Atherosclerosis is a very common disease in which fat deposition in the inner layers of arteries leading to plaques formation.Dapagliflozin is one of a new class of drugs known as the sodium‑glucose cotransporter‑2 inhibitors, responsible for lowering of the bloodglucose level, and enhancing urinary glucose excretion. Dapagliflozin may lower blood glucose levels and at the same time prevent cardiovasculardiseases. Objective: The objective of this study was to assess the effect of dapagliflozin on atherosclerosis through interfering with inflammatoryand oxidative pathways. Materials and Methods: Eighteen local domestic male rabbits were used in this study. The rabbits were randomlydivided into three groups: Group I rabbits fed normal chow diet for 12 weeks; Group II rabbits fed with 0.5% cholesterol‑enriched diet; andGroup III rabbits fed with 0.5% cholesterol‑enriched diet together with dapagliflozin (1 mg/kg once daily). Blood samples were collectedbefore the study (zero time) and every 4 weeks for the measurement of serum total cholesterol, triglycerides (TGs), high‑density lipoproteincholesterol (HDL‑C), low‑density lipoprotein cholesterol (LDL‑C), very LDL‑C (VLDL‑C), tumor necrosis factor alpha (TNF‑α), andendothelin‑1 (ET‑1). Results: Dapagliflozin treatment showed insignificant elevation in total cholesterol and LDL‑C, significant decreaseVLDL‑C and TG, and significant elevation of HDL‑C level (P < 0.05) compared with the induced untreated group. It was insignificantlydecreased inflammatory markers (TNF‑α and ET‑1), increased aortic total antioxidant capacity, and significantly reduced aortic intima thicknesscompared with induced untreated group. Dapagliflozin, by slightly interfering with inflammatory and oxidative pathways, may show beneficialeffects on atherosclerosis and can attenuate the atherosclerotic lesion formation. Conclusion: Dapagliflozin may have a beneficial effect onatherosclerosis by slightly interfering with inflammatory and oxidative pathways and can reduce the atherosclerotic lesion formation; however,our study needs further clinical studies to be carried out on large population.


Article
Effect of Zinc Sulfate on Kidney Function in Cisplatin-Treated Cancer Patients

Authors: Ihsan Salah Rabeea1 --- Amina Abdul Baqi Al Dujeli2 --- Fadhil Abdul Jabbar Rizij --- Ayad Ali Hussein
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2016 Volume: 9 Issue: 2 Pages: 2505-2512
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: cisplatin is a potent chemotherapeutic agent that is currently used in management of many and various types of tumors. Cisplatin causes dose-related nephrotoxicity that significantly affects kidney function and limits cisplatin use with maximum required dose and usefulness. This study was to assess the protective and ameliorativen effect of zinc sulfate on kidney function and nephrotoxicity caused by cisplatin in cancer patients. Patients and methods: 41 patients were enrolled in the study and were randomized into two groups. Patients in group I (N=20) received cisplatin based regimen every 21 days for six consecutive cycles. Patients in group II (N=21) received zinc sulfate plus cisplatin based regimen during the six consecutive cycles of treatment. Serum urea, creatinine and magnesium levels were measured at base line and 21 days after 1, 2, 4 and 6 cycles of cisplatin based regimen. The glomerular filtration rate of patients was calculated according to updated version of the Modification of Diet in renal Diseases formula. Results: In group I, cisplatin based regimen after 6 cycles of treatment caused significant (P<0.05) increment in serum urea and creatinine and significant (P<0.05) decline in The glomerular filtration rate and magnesium in comparison to base line levels. Serum urea and creatinine levels of group II were significantly (P<0.05) lower than that of group I while glomerular filtration rate and magnesium were significantly (P<0.05) higher than that of group I.Conclusion: zinc sulfate significantly ameliorated nephrotoxicity and improving kidney function in cisplatin-treated patients.

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