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21- STUDY THE EFFECT OF CAFFEINE ON BODY WEIGHT GAIN AND LIPID PROFILE IN ADULT MALE RATS TREATED WITH HYDROGEN PEROXIDE.

Author: Faraj H.Joni AL-Bidhani , .Adel M. Hassen Alzobidy .Abdul Razzak N. Khudair
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: 18138497 Year: 2018 Volume: 17 Issue: 1 Pages: 246-256
Publisher: Basrah University جامعة البصرة

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Abstract

The present study was aimed to determine the ameliorative effect of caffeine onBody weight and lipid profile in male rats treated with hydrogen peroxide (H2O2) .Seventy Two adult male rats were used in this study . The study included twoexperiments ,in each experiments 36 males were randomly assigned two six equal groupsof six animals in each group .The animals in both experiments were treated with thesame substances and doses for each group as follows .Group one (control) animals weredrenched normal saline ,Group two animals were treated (5.63 mg/kg. Bw )H2O2 dailyby oral gavage also group three , animals were treated with low dose caffeine (150 mg/kg Bw) daily .Group four , animals were treated with high dose caffeine (250 mg /kgBw) daily . Group five . animals were treated (5.63 mg/kg. Bw )H2O2 dose after 1 hanimals were given low dose of caffeine (150 mg/kg Bw) .Group Six animal weretreated with H2O2 dose(5.63 mg/kg Bw) each rat after one hour was given high dose ofcaffeine (250 mg /Kg Bw) . The first experiments lasted for one month and secondexperiments lasted for two months . At the end of the two experiments, animals of allgroup were sacrificed under chloroform anesthesia .Blood samples were collected from the heart directly by cardiac puncture and the serum was separated to measure the lipidprofile .The result revealed a significant decreased in body weight gain in H2O2in first andsecond experiments compared with control group . While a significant improvementswere recorded in body weight gain in all treated groups compared with H2O2 group butstill significantly lower compared with those of control group. A significant increase inTC ,TG and LDL-c were recorded in H2O2 group in both experiments compared withcontrol group on the other hand no significant difference was recorded in HDL-c levelin H2O2group in first experiments while a significant decreased was recorded in secondexperiments compared with control group . Finally a significant degrees ofimprovement were observed in lipid profile in all treated group compared with H2O2 .

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