research centers


Search results: Found 2

Listing 1 - 2 of 2
Sort by

Article
Goserelin versus Norethisterone in the Management of Menorrhagia with Uterine Fibroid

Authors: Yousif Abdul-Raheem --- Jwan N. Sulaiman --- Faris A. Rasheed
Journal: Iraqi Journal of Pharmaceutical Sciences المجلة العراقية للعلوم الصيدلانية ISSN: 16833597 Year: 2010 Volume: 19 Issue: 2 Pages: 54-58
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Menorrhagia is common in patients with uterine fibroids, if operation needs to be delayed for a particular reason, goserelin can be used safely to reduce bleeding and the size of the tumor.The objective is to compare between goserelin acetate and norethisterone on patients with menorrhagia and uterine fibroid. A randomized controlled study conducted in Elwiya maternity teaching hospital, Baghdad from the first of November 2007 to the end of April 2009. 90 patients from the consultant outpatient clinic with menorrhagia and fibroid, and their operations were delayed for medical reason were allocated in two groups, the first group, was given 3.2 mg goserelin acetate subcutaneously monthly for 3 months and the second group was given 5 mg norethisterone orally three times daily during the attack of bleeding and 5 mg once daily, cyclically if no bleeding for 3 months. The fibroid was measured in two dimensions, using convex real-time ultrasound before treatment and three months after treatment. Haemoglobin and the number of pads used were also reported before and after treatment, also the side effects in both groups and the need for operations.The size of fibroid in two dimensions measurement was reduced from 28.24 cm2 ± 6.14 to 12.3 cm2 ± 3.45 in the goserelin group (P=0.0001) versus 26.56 cm2 ± 5.96 to 25.22 cm2 ± 5.01 in the norethisterone group (P= 0.2589). The haemoglobin level was 9.28 gm/100ml ± 2.44 pre-treatment in the goserelin group and 11.2 gm/100ml ± 1.88 post-treatment (P= 0.0001) versus 10.08 gm/100ml ± 2.86, and 10.24 gm/100ml ± 2.46 respectively in the norethisterone group (P= 0.7798). The need for operation was decreased significantly in the goserelin group. Goserelin showed better patient response and reduction in the tumor size than norethisterone in treatment of patients with menorrhagia and uterine fibroids if operation is delayed for medical or other reasons.

إن دواء كوزرلين ( Goserlin ) يظهر نتائج أفضل من دواء ( نوراثي ستيرون ) Norethisterone في معالجة وتقليص حجم العقد الليفية في الرحم و خاصة عند المريضات اللواتي يعانين من نزف شديد أثناء الدورة الشهرية أو هناك أسباب طبية تؤدي إلى تأجيل عملية رفع العقد الليفية جراحياً . ووجد أن إعطاء دواء ( الكوزرلين ) ) Goserlin ) لمدة 3 أشهر فعال في معالجة المريضات اللواتي يعانين من نزف شديد أثناء الدورة الشهرية بسبب وجود عقد ليفية على الرحم إذ وجد انه يقلل من شدة النزف ويرفع من نسبة الهيموكلوبين بالدم مما يقلل الحاجة إلى إعطاء دم أو اللجوء إلى التداخل الجراحي مع وجود إعراض جانبية طفيفة .


Article
MATERNAL AND FETAL OUTCOMES IN EMERGENCY VERSUS ELECTIVE TWO OR MORE PREVIOUS CAESAREAN DELIVERIES

Authors: Yousif A AL-Raheem يوسف عبد الرحيم --- Thikra Najim ذكرى نجم --- Faris A Rasheed فارس رشيد
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2010 Volume: 6 Issue: 1 Pages: 108-117
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background: Women with previous two or more caesarean deliveries are usually managed by elective cesarean section to avoid the possible risks of labor. Objective: To compare the relative risks of maternal and fetal outcomes in emergency versus elective previous two or more caesarean deliveriesDesign: Randomized prospective clinical studySetting: Al-Elweya Maternity Teaching Hospital, from 1st of March to 31st of September 2008.Methods: The study groups, those who had previous two or more caesarean deliveries, were included from the hospital admissions. The 1st group (102 women) presented in labor and was managed by caesarean delivery as soon as it was possible. The second group (78 women) was admitted for elective cesarean delivery.The main maternal outcomes were intra operative complications, including hysterectomy, scar dehiscence, bladder injuries, uterine and internal iliac arteries ligation, and blood transfusion. Postoperative maternal outcomes were severe morbidity including bleeding, fever, urinary tract infection, blood transfusion, the need to Intensive Care Unit admission and readmission. The fetal outcomes measures were Apgar score at one and five minutes, respiratory distress syndrome (RDS), admission to the neonatal intensive care unit and fetal loss up to hospital discharge.Results: Both groups were comparable in demographic, social and past obstetric history characteristics. Intra operative complications showed significant difference in bowel adhesions (RR 0.35, 95% CI 0.14- 0.88), and blood transfusion (RR 0.51, 95% CI 0.28-0.94). There was statistical significant difference in the mobilization time 7.2 hours and 9.3 hours in emergency and elective groups respectively (p= 0.0009), also in feeding time, it was shorter after emergency caesarean section (P=0.0224), and in the hospital stay 24.6 and 32.6 hours respectively (p=0.0001). There was no statistical difference in post operative complications. Fetal outcomes showed no statistical significant difference in fetal loss, respiratory distress and readmission.Conclusion: Women with previous two or more caesarean deliveries can wait until starting labor for doing cesarean delivery without increasing risks to the mother and fetus.

Listing 1 - 2 of 2
Sort by
Narrow your search

Resource type

article (2)


Language

English (2)


Year
From To Submit

2010 (2)