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Article
Effect of N-acetylcysteine on wound healing in burned patients

Author: Faruk H. Al-Jawad
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2011 Volume: 10 Issue: 1 Pages: 28-31
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background The magnitude of free radical generation and their disposal mechanisms are known to be altered in burn; and there is some kind of correlation exists between altered free radical cascades and delay wound healing. Aims Exploration of the variable effect of N-acetylcysteine on Wound Healing in Burned Patients. Methods 60 burned patients with different ages of both sexes and varying burn percentage were involved in this study. Patients allocated into 2 groups: A, B each group include 30 patients. Groups: B treated with antioxidant N-acetylcysteine, compared with group A which is treated according to hospital policy without antioxidant; also 30 healthy subjects (group C) were involved in the study as control group for comparison.To each group, serum malondialdehyde and serum glutathione levels, microbiological examination, healing time and mortality rate were measured depending on standard methods. Results Administration of N-acetylcysteine to burned patients produce significant reduction in the wound healing time and improvement in mortality rate, compared to group A, where no antioxidant was given. Conclusions This study clearly showed the beneficial effect of N-acetylcysteine in the treatment of burned patients represented by shortening of healing time, in addition to reduction in hospitalization period; it is recommended to add antioxidant to the treatment list of burned patients.


Article
The Role of Some Medicinal Plants in the Management of Peptic Ulcer

Author: Faruk H. Al-Jawad فاروق الجواد
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2011 Volume: 7 Issue: 2 Pages: 51-58
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Plants used in folk medicine for the treatment of peptic ulcer diseases is a very promising approach to overcome the limitations of classical medicines. Aim: To explore the efficacy of medicinal plants, namely turmeric, garlic and marshmallow, in eradication of H. pylori. Methods: This prospective study was carried out on 225 of well-known dyspeptic patients who were divided into four groups; a control group (received classical medical therapy) and three other groups that received one of the three medicinal plants, plus the same therapy used in the control group. The follow up was done by using a questionnaire form, endoscopic examination, and determination of serum levels of anti H.pylori antibodies & gastrin by using ELISA test. In addition, liver enzymes were monitored by using spectro-photometer to prove the safety of medicinal plants. Results: The rate of recurrence of peptic ulcer disease was decreased in patients who received the combined therapy when compared to the patients in control group. Medicinal plants were effective in decreasing the recurrence of H. pylori infection when each one of them was used in combination with the medical therapy without causing harmful effects on the liver. Conclusion: Turmeric, garlic & marshmallow are effective in management of peptic ulcer with low cost.


Article
The effect of prednisolon and celery seed in treatment of chronic bronchial asthma
تاثير عقار البردنزولون وبذور الكرفس في علاج الربو القصبي المزمن

Author: Albayati N.Jalal ; Faruk H. Al- Jawad ; Ayden K. Muhammad
Journal: KUFA MEDICAL JOURNAL مجلة الكوفة الطبية ISSN: 1993517X Year: 2009 Volume: 12 Issue: 1 Pages: 135-140
Publisher: University of Kufa جامعة الكوفة

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Abstract

The effectiveness of some drugs and plants in management and prophylaxis of chronic asthma have been explored in this study . The tested agent used solely or in combination as mixture in order to increase the pharmacological efficacy or to decrease the hazardous effects by using the alternatives from plants. The present study was carried out in the college hospital of kadhumia teaching University . fifty adult patients of both sexes were involved in this study. Addition of celery seed to prednisolone lead to improvement of pulmonary function from 78.30±3.39 % , 2.25±0.16 L before treatment to 84.75±3.35 %, 3.06±0.05 L respectively after treatment The improvement in pulmonary function after treatment with celery seeds coincides with significant increase in Calcium , magnesium and selenium levels in serum.

تم دراسة تاثير بعض العقاقير والنباتات الطبية في علاج والوقاية من الربو القصبي المزمن 0 المواد التي استخدمت بشكل منفرد او بشكل خلطات وذلك من اجل زيادة الفعالية الدوائية او لتقليل التاثيرات الجانبية للعقار0اجريت هذه الدراسة في مستشفى الكاظمية التعليمي على خمسين مريضا بالغا من كلا الجنسين 0 وجد ان استخدام بذور الكرفس مع عقار البردنزولون ادى لزيادة في وضائف الرئة من 78.30±3.39 % , 2.25±0.16 L الى 84.75±3.35 %, 3.06±0.05 L على التوالي بعد العلاج 0 ان التحسن في وضائف الرئة حدثت بعد العلاج ببذور الكرفس مع تحسن معنوي في مستوى الكالسيوم والمغنيسيوم والسلينيوم في بلازما الدم0

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Article
the hypoglycemic effect of extract of some medicinal plants in diabetes induced rabbits
الفعالية المضادة للتايفوئيد لبعض مستخلصات النباتات الطبية في الارانب

Author: faruk h. al-jawad ا.د.فاروق حسن جواد
Journal: AL-yarmouk Journall مجلة كلية اليرموك الجامعة ISSN: 20752954 Year: 2011 Issue: 1 Pages: 17-26
Publisher: College Yarmouk University كلية اليرموك الجامعة

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Abstract

References1. WHO monograph for selected medicinal plants Volume I-, Geneva 1999.2. Bailey.C & Day.C: Traditional plant medicines. Diabetes care; 12; 553-64, 1989.3. Trinder.P: Determination of glucose in blood using glucose oxidase. Ann- Clin Biochem.6; 24-27,1969.4. Snederos.GW&Cochran.WG: Statistical methods .8t" edition, Lowa state univpren U.S.A 1981.5. John. B,Watkins.IC,and sanders.PA: Diabetes mellitus induced alteration in the hepatobiliary function. Am. Society for pharma & experimental therapeutics; 47-1-17, 1995.6. Edward.CRW, Baird. JD, Frier. BM: Endocrine and metabolicdisease .17 th ed. Edinburgh, Churchill Livingston, 1995.7. Rubenstien.AH, Leven.NH and Elliott.GA: Manganese -inducedhypoglycemia. Lancet; 1348-51,1962.8. Reddys. A, King GL: The insulin receptor and update in the diabetes.Annual; Vo13 Albertic KGMM, Amst Elsevier ;449-458 , 1987.9. Glombitza. KW, Mahran.GH and Motawi.TK: Hypoglycemic and antihyperglycemic effect of zizspina Christi in rats. Planta Med ;Vol 6214-247, 1993.10. Gray.AM and Flatt. PR: Pancreatic and extra pancreatic effects oftraditional anti diabetic plant, Medicago Sativa.Br.J.Nutr; 78, 325-334 11. Augusti.KT& Benaim.ME: Effect of essential oil of onion (allyl propyl disulphide) on blood glucose, free fatty acid and insulin levelsof normal subject. Clin.Chem. Acta; 60,121-23,1975. 12. Sheela.CG, Kumud. K & Augusti. KT: Anti diabetic effects of onion and garlic sulfoxide amino acids in rat. Planta Med; 61(4), 356¬7,1995.13. Kasuga.S, Ushijima. M & Morihara. N: Effect of aged garlic extract on hyperglycemia induced by stress in mice. Nippon¬Yakurigaku-Zasshi; 114(3), 191-7,1999.14. Mishinsky.J,Joseph.B,Sulman.FG&Goldschmied.A:Hypoglycemic effect of trigonelline. Lancet; 2,1311-12,1967.15. Roman-Ramos.R,Flores-Saenz.ZL,Alarcon-Aguilar.FJ:Antihyperglycemic effect of some edible plants .J.Ethanopharmocol;48(1)25-32,1995.16. Joerg Gruenwaid,Thomas Brendler et.al: PDR for herbal medicine Medical economics company, montvale- newjersey, 1998.17. Ziyyat.A, Legssyer. A,Meknfi. H, Dassouli. A, et al: Phytotherapyof hypertension and diabetes in oriental. Morocco. J.Ethanopharmocol;58(1), 45-54,1997.18. Shani.J,Goldshmied.A, Joseph.B,Sulman.FG: Hypoglycemic effect of Tigonella foenum graecum and lupinus termis seeds & their major alkeloids. Arch. Int. Pharmacodyna Thr; 210,27-37,1974.19. Ribes.G,Sauvaire.Y,Baccou.JC: Effects of fenugreek seeds on endocrine pancreatic secretions in dogs .Ann.Nutr.Metab ;28,37¬42,1984.20. Haefele.C,Bonfils.C&Sauvaire.Y: Characterization of a dioxygenase from trigonella foenum graecum involved in 4-hydroxy isoleucine biosynthesis. Phytochemis; 44(4), 563-6, 1997.21. Genet.S, Kale.RK & Baquer. NZ: Effects of vandate, insulin and fenugreek on creatine kinase levels in tissue of diabetic rat. Indian J.Exp.Biol; 37(2), 200-2, 199922. Rajin.J, Gupta.D, Rao.AR, and Bauer.NZ: Effect of anti diabetic compounds on glycoxalase activity in experimental diabetic rat liver. Indian J. Exp.Biol; 37(2) 193-5,1999.23. Bordia.A,Verma.SK,Srivastava.KC: Effect of ginger and fenugreek on blood sugar and platelet aggregation in-patients with coronary artery disease. Prostag. leuko.Essent.Fatty Acids; 56(5), 379¬84,1997.

الـخـلاصـة :-تم توثيق الالوكسات (100 ملغم / كغم ) لإحداث داء السكر في الحيوانات التجريبية ولقد قيس مستوى السكر بالدم قبل وبعد أعطاء الالوكسات وكذلك بعد أعطاء الأنسولين أو الخلاصة المائية للنباتات الطبية حيث سبب الأنسولين (2 وحدة قياسية /كغم ) تحت الجلد انخفاضا معتدا بمستوى سكر الدم وكذلك ألجت ( 5غم/كغم ) والثوم (1غم/كغم ) والمعدنوس (4غم/كغم ) والحلبة (6غم/كغم ) والفاصوليا (4غم/كغم ) وغيرها تسبب انخفاضا معتدا بمستوى السكر بالدم ما عدا الياس حيث يمكن الاستفادة منه في معالجة داء السكري .


Article
The relaxant effect of some drugs and aqueousextract of medicinal plants on bionchial smoothmuscle in rabbits
تأثير بعض الادوية والمستخلص المائي للنباتات الطبية على العضلة القصبية الملساء في الارانب

Authors: Waseem Al_Jumaily وسيم الجميلي --- Faruk H. Al-Jawad فاروق حسن جواد
Journal: Tikret Journal of Pharmaceutical Sciences مجلة تكريت للعلوم الصيدلانية ISSN: 18172716 Year: 2005 Volume: 1 Issue: 1 Pages: 58-63
Publisher: Tikrit University جامعة تكريت

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Abstract

Histamine is a biogenic amine. that produces bronchospasm when it is used (I V)
at.a.dose of 0.4 mg / kg in rabbits. It significantly reduced the ,e*- l"u"i. oi
calcium (Ca) magnesium (Mg) and selenium (Se). (p < 0.05) .
Forty rabbits were involved in this study. The serum ca, Mg and Se levels were
measured before and after giving histamine and following [e administration oi
aqueous extract of medicinal plants Cumi'um cyminum (cumin), Thymus vulgaris
(thyme) and Anthemis nobilis (chamomile).
^ The serum Ca, Mg and Se levels of were highly elevated after treatment with extract cumin or chamomile in rabbits pretreated with histamine, the resurts of ca were
changed lrom 8.34+ 0.40 and 8.79+ 0,27 to 33.41+ 0.50 and 97.62 ! 7.2 1tg /dl
respectively while that of Mg from 20.20+ 0.37 and 19.47+ 0.31 to 74.97+ 0.ii and
89.14+ 1.41 pg /dl where as the serum level of Se was changed from 137.9g+ 0.4g
and 145 36 + 0.66 ro 302.69 ! 0.6g and 245.4r,' 0.g1 pg /direspectivery .All these
results were significant at p<0.05.
The aqueous extracts of cumin or chamomile were used orally at a dose of 1.5 gm /kg in rabbits to relieve the bronchospasm and symptoms of dyspnea induced iy histamine. These results indicated crearly the po*iuiiity of using these extracts flr patients with chronic asthma after the adjustment ofthe effective dose.

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Article
The Effect of Cinnamomum Verum on Serum Glucose, GOT, GPT and Creatinine in Patients With Type-2 Diabetes Mellitus

Authors: Faruk H. Al-Jawad --- Hashim M. Hashim --- Batool A. Al-Khafaji
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2005 Volume: 2 Issue: 1 Pages: 19-22
Publisher: Babylon University جامعة بابل

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Abstract

The possible effect of Cinnamomum verum on blood glucose was studied in patients with type-2 diabetes. Its effects on hepatic and renal function, and presence of other side effects were evaluated. Fasting blood glucose and serum GOT, GPT and creatinine levels were measured. The results shown that Cinnamomum verum produce significant decrease in serum glucose levels (P<0.05), while there was non significant changes (P>0.05) in serum GOT, GPT and creatinine levels. There was no mentioned side effect except gastric burning in one patient only

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Article
The Hypoglycemic Effect of Some Medicinal Plants in Normal and Experimentally Induced Diabetic Rabbits

Authors: Batool A. Al-Khafaji --- Hashim M. Hashim --- Faruk H. Al-Jawad
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2005 Volume: 2 Issue: 1 Pages: 38-44
Publisher: Babylon University جامعة بابل

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Abstract

Alloxan (180mg/Kg] I.V is an effective diabetogenic agent that induces diabetes mellitus in rabbits. Ninety healthy male rabbits were involved in this study. The plasma glucose levels were measured in normal and in diabetic rabbits after giving alloxan and following the administration of glibenclamide, insulin and the aqueous extract of medicinal plants. Insulin (2IU/Kg] S.C produced a significant reduction in plasma glucose levels in diabetic rabbits (b= -3.87 P< 0.001]. In the mean time, the aqueous extract of Cinnamomum verum, Nigella sativa and Olea europea at a single dose of 0.5g/Kg orally caused a significant lowering of plasma glucose levels in diabetic rabbits with b=(-2.38], (-2.34 ] and (-1.17] respectively (P< 0.05], whereas the aqueous extract of both Capparis spinos and Coriandum sativum at the same dose produced non significant decrease in plasma glucose levels of diabetic rabbits with b= (-0.86] and (-0.98] respectively (P> 0.05]. The aqueous extract of medicinal plants significantly decreased the plasma glucose levels in normal rabbits except with Capparis spinos, whereas glibenclamide insignificantly reduced the plasma glucose levels in diabetic rabbits.

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Article
Effect of Aqueous Extract of Some Medicinal Plants on Plasma Lipid Profile in Diabetes Induced Rabbits

Authors: Batool A. Al-khafaji --- Hashim M. Hashim --- Faruk H. Al-jawad
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2005 Volume: 2 Issue: 1 Pages: 114-119
Publisher: Babylon University جامعة بابل

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Abstract

Alloxan (180mg/kg) i.v is a potent diabetogenic agent that induces diabetes mellitus in rabbits with hypercholesterolemia and hypertriglyceridemia . Fifty-four healthy male rabbits were involved in this study. Both plasma cholesterol and triglyceride levels were measured before and after giving alloxan and following administration of insulin, glibenclamide or aqueous extract of medicinal plants. Insulin (2 IU/kg) S.C produced a significant reduction in both plasma cholesterol (b=-1.05 p<0.005] and triglyceride levels (b=-1.19 P<0.01) whereas glibenclamide (70mg/kg) per Os produced no significant changes in these values. In the mean time the aqueous extract of Nigella sativa (0.5g /kg] produced a significant decrease in both cholesterol and triglyceride levels with (b=-0.65 P<0.05) and (b=-1.28 P<0.05) whereas Capparis spinos caused a significant decrease in plasma cholesterol levels only with (b=-0.83 P<0.01). Finally the extract of Coriandrum sativum ,Oleoe uropea and Cinnamomum verum produced a significant reduction in triglyceride levels with (b=-1.12 P<0.05),(b=-0.97 P<0.05) and (b=-1.01 P<0.01) respectively but with no significant change in cholesterol levels. There is no significant correlation between the hypoglycemic effects of medicinal plants and their hypocholesterlemic & hypotriglyceridemic effect. Also the possibility of using Nigella sativa and Cinnamomum verum for diabetic patients with type- ll but this needs more clinical trials. Keyword cholesterol, triglyceride, medicinal plants

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Article
USING ATORVASTATIN AND L-CARNITINE IN PREVENTION OF PILOCARPINE-INDUCED SEIZURES: ANIMAL MODEL STUDY

Authors: Uday AR. Hussein عدي عبد الرضا حسين --- Faruk H. Al-Jawad فاروق حسن الجواد
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2014 Volume: 12 Issue: 2 Pages: 156-160
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:Epilepsy is a common chronic neurological disorder characterized by recurrent unprovoked seizures.Objective:To investigate the possible antiepileptic effect of both atorvastatin and L-carnitine on seizure induced by pilocarpine.Methods:Fifty male albino mice weighing between 30-35 gm were equally allocated into five groups (each group contained 10 mice) and were given one of the following; control group; distal water group (0.1 ml), diazepam group (1mg/kg), atorvastatin group (5 mg/kg) and L-carnitine group (300 mg/kg). All animals (except normal group) were injected with Pilocarpine hydrochloride (350 mg/kg) to induce generalized tonic-clonic seizures 30 minutes after the tested drugs had been administrated. The mean onset of seizure were determined as well as the mean serum concentration of electrolytes, glutathione (GSH) and malondialdehyde (MDA) were measured after seizure had been induced.Results:Pilocarpine induced seizure at approximately 7 minutes after injection, while both atorvastatin and L-carnitine produced highly significant increase in mean onset of seizure 14 ± 0.471 and 14.5 ± 0.909 respectively as compared to that of D.W. group, also both drugs produced highly significant changes in mean serum concentration of electrolytes, GSH and MDA.Conclusion:Atorvastatin and L-carnitine had antiepileptic effects against seizures induced by pilocarpine when used at applied doses.Key words:Epileptic seizure, Atorvastatin and L-carnitine.


Article
EFFECTS OF VERAPAMIL AND OLANZAPINE IN TERMINATING PILOCARPINE- INDUCED EPILEPTIC SEIZURES IN MICE.

Authors: Uday A. Hussein عدي عبد الرضا حسين --- Faruk H. Al-Jawad فاروق حسن الجواد
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2014 Volume: 12 Issue: 2 Pages: 180-184
Publisher: Al-Nahrain University جامعة النهرين

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Background:Epilepsy is one of the oldest known neurological conditions characterized by recurrent seizures.Objective:To explore the possible antiepileptic effect of both Verapamil and Olanzapine in pilocarpine epileptic model in mice.Methods:Fifty healthy male albino mice weighing between 30-35 gm were equally allocated into five groups (10 mice in each group) and were distributed into: normal group (without drug); distilled water group (0.1 ml); diazepam group (1mg/kg); verapamil group (20 mg/kg) and olanzapine group (10 mg/kg). All animals (except normal group) were injected with pilocarpine hydrochloride (350 mg/kg) to induce generalized tonic-clonic seizure 30 minutes after the tested drugs had been administrated. The mean onset of seizure were determined as well as the mean serum concentration of electrolytes, glutathione and malondialdehyde were measured after seizure had been induced.Results:Pilocarpine-induced seizure at approximately 7 minutes after injection. While both verapamil and olanzapine produced highly significant increase in mean onset of seizure 16±1.549 and 13.1±1.566 respectively as compared to D.W. group, also both drugs produced highly significant changes in mean serum concentration of electrolytes, glutathione and malondialdehyde.Conclusion:Verapamil and olanzapine had anticonvulsant activity when used at applied doses in the pilocarpine model of seizures in mice.Key words:Epilepsy, seizure, verapamil and olanzapine.

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