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USING ATORVASTATIN AND L-CARNITINE IN PREVENTION OF PILOCARPINE-INDUCED SEIZURES: ANIMAL MODEL STUDY

Authors: Uday AR. Hussein عدي عبد الرضا حسين --- Faruk H. Al-Jawad فاروق حسن الجواد
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2014 Volume: 12 Issue: 2 Pages: 156-160
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:Epilepsy is a common chronic neurological disorder characterized by recurrent unprovoked seizures.Objective:To investigate the possible antiepileptic effect of both atorvastatin and L-carnitine on seizure induced by pilocarpine.Methods:Fifty male albino mice weighing between 30-35 gm were equally allocated into five groups (each group contained 10 mice) and were given one of the following; control group; distal water group (0.1 ml), diazepam group (1mg/kg), atorvastatin group (5 mg/kg) and L-carnitine group (300 mg/kg). All animals (except normal group) were injected with Pilocarpine hydrochloride (350 mg/kg) to induce generalized tonic-clonic seizures 30 minutes after the tested drugs had been administrated. The mean onset of seizure were determined as well as the mean serum concentration of electrolytes, glutathione (GSH) and malondialdehyde (MDA) were measured after seizure had been induced.Results:Pilocarpine induced seizure at approximately 7 minutes after injection, while both atorvastatin and L-carnitine produced highly significant increase in mean onset of seizure 14 ± 0.471 and 14.5 ± 0.909 respectively as compared to that of D.W. group, also both drugs produced highly significant changes in mean serum concentration of electrolytes, GSH and MDA.Conclusion:Atorvastatin and L-carnitine had antiepileptic effects against seizures induced by pilocarpine when used at applied doses.Key words:Epileptic seizure, Atorvastatin and L-carnitine.


Article
EFFECTS OF VERAPAMIL AND OLANZAPINE IN TERMINATING PILOCARPINE- INDUCED EPILEPTIC SEIZURES IN MICE.

Authors: Uday A. Hussein عدي عبد الرضا حسين --- Faruk H. Al-Jawad فاروق حسن الجواد
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2014 Volume: 12 Issue: 2 Pages: 180-184
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:Epilepsy is one of the oldest known neurological conditions characterized by recurrent seizures.Objective:To explore the possible antiepileptic effect of both Verapamil and Olanzapine in pilocarpine epileptic model in mice.Methods:Fifty healthy male albino mice weighing between 30-35 gm were equally allocated into five groups (10 mice in each group) and were distributed into: normal group (without drug); distilled water group (0.1 ml); diazepam group (1mg/kg); verapamil group (20 mg/kg) and olanzapine group (10 mg/kg). All animals (except normal group) were injected with pilocarpine hydrochloride (350 mg/kg) to induce generalized tonic-clonic seizure 30 minutes after the tested drugs had been administrated. The mean onset of seizure were determined as well as the mean serum concentration of electrolytes, glutathione and malondialdehyde were measured after seizure had been induced.Results:Pilocarpine-induced seizure at approximately 7 minutes after injection. While both verapamil and olanzapine produced highly significant increase in mean onset of seizure 16±1.549 and 13.1±1.566 respectively as compared to D.W. group, also both drugs produced highly significant changes in mean serum concentration of electrolytes, glutathione and malondialdehyde.Conclusion:Verapamil and olanzapine had anticonvulsant activity when used at applied doses in the pilocarpine model of seizures in mice.Key words:Epilepsy, seizure, verapamil and olanzapine.


Article
ROLE OF VITAMIN E, L-CARNITINE AND MELATONIN IN MANAGEMENT OF Β-THALASSEMIA MAJOR

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Abstract

Background:β-thalassemia major is an inherited disease resulting from decrease or total lack of β globin chains. Patients with this disease need repeated blood transfusion for survival. This may cause oxidative stress and tissue injury due to iron overload and depletion of antioxidant enzymes.Objective:Evaluation the role of vitamin E, L- carnitine and melatonin supplementation in management of β-thalassemia major patients.Methods:Forty five patients with β-thalassemia major were allocated to three groups A, B and C treated with vitamin E, L-carnitine and melatonin respectively. Serum malondialdehyde, serum reduced glutathione, serum ferritin, Hb, PCV, MCV, MCH, and MCHC levels and RBCs count were measured before and after treatment.Results:A significant decrease was observed in serum malondialdehyde and ferritin level after therapy in all treated groups; whereas, no significant (P > 0.05) changes in glutathione level after treatment in all groups. Hb level and RBC count increased significantly in group A (vitamin E), whereas, PCV, MCV, MCH and MCHC levels did not change significantly in all treated groups.Conclusion:Vitamin E, L- carnitine and melatonin have beneficial effects of in reducing lipid peroxidation and iron overload in patients with β-thalassemia major. These antioxidants may increase the life span of RBCs, which manifested by significant increase in Hb level in vitamin E treated group and significant decrease in serum ferritin level in all treated groups.Keywords:Beta-thalassemia, malondialdehyde, glutathione, ferritin, hematological parameters, vitamin E, L- carnitine, melatonin.


Article
EFFECTS OF CYTOCHROME P-450 INDUCER AND INHIBITOR ANTIEPILEPTIC DRUGS ON LIPID PROFILE IN NORMAL AND DIABETIC RABBITS

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Abstract

Background: Anticonvulsants drugs are a diverse group of pharmacological agents used in the treatment of epileptic seizures are known to inhibit or activate cytochrome p-450 enzymes that play a crucial rule in the metabolic process.Objective:To investigate any possible differences in the effect of antiepileptic drugs; enzyme inducer (carbamazepine) and enzyme inhibitor (lamotrigine) on lipid profile in normal and diabetic rabbits depending on its effect on cytochrome p-450 enzymes.Methods:Fifty four healthy domestic rabbits of both sexes weighing 0.5-2.5 kg were studied. They were divided into group A (standard) received tolamatrigine and carbamazepine without induction of diabetes and group B (received the same regimen) with induction of diabetes. Lipid profile was tested in the two groups. Results: Carbamazepine-treated group showed a significant increase in the lipid profile at day 20 of treatment compared to day 5 in comparison with induced and non-induced control groups and control group in normal and diabetic rabbits. Lamotrigine showed less effect on lipid profile; and in non-diabetic treated groups it showed a non-significant change in lipids level as compared to the control group.Conclusions:Anti-epileptics drugs that possess an enzyme inducing effect as carbamezpin tend to induce high lipids profile in comparison to lamotigine.Keyword: Lamotrigine, carbamazepine, anticonvulsants, glucose, lipid.

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