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Article
Leptin in Goitrous patients

Author: Feryal Hashim Rada
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2009 Volume: 8 Issue: 1 Pages: 33-35
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Objective To evaluate the relationship between serum Leptin levels and metabolic syndrome, in (obese, non-obese) control subjects, untreated hypothyroid and hyperthyroid patients. Methods A study was made on 63 goitrous patients and 25 control subjects. Body mass index (BMI) was calculated. Serum T3, T4, TSH were measured by RIA method, serum lipid profile was measured by spectrophotometric method, serum Leptin was measured by ELISA method. Results The mean serum Leptin level was significantly higher in obese than in non-obese control subjects (29.1 vs. 5.8 ngm / ml) and higher in hypothyroid patients (27.9 ngm /ml), and lowest levels in hyperthyroid patients (3.4 ngm /ml). Conclusion Leptin reduce body weight by decreasing food intake (appetite), fat deposition and increasing energy expenditure. Serum Leptin is highly correlated with the body mass index (BMI), other indices of adiposity (lipid profile) in normal obese human and hypothyroid patients.


Article
Leptin in Goitrous patients

Authors: Feryal Hashim Rada --- Nahla Al-Sakkal --- Abdul-Karim Yahia
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2008 Volume: 7 Issue: 2 Pages: 33-35
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Objective: To evaluate the relationship between serum Leptin levels and metabolic syndrome, in (obese, non obese) control subjects, untreated hypothyroid and hyperthyroid patients.Methods: A study was made on 63 goitrous patients and 25 control subjects. Body mass index (BMI) was calculated. Serum T3, T4, TSH were measured by RIA method, serum lipid profile was measured by spectrophotometric method, serum Leptin was measured by ELISA method.Results: The mean serum Leptin level was significantly higher in obese than in non obese control subjects (29.1 vs. 5.8 ngm / ml) and higher in hypothyroid patients (27.9 ngm /ml), and lowest levels in hyperthyroid patients (3.4 ngm /ml). Conclusion: Leptin reduce body weight by decreasing food intake (appetite), fat deposition and increasing energy expenditure. Serum Leptin is highly correlated with the body mass index (BMI), other indices of adiposity (lipid profile) in normal obese human and hypothyroid patients.


Article
Hepatotoxicity of Combined Therapy of Atorvastatin with Platelet P2Y12-ADP Receptor Antagonist in Coronary Heart Disease Treated Patients

Authors: Feryal Hashim Rada --- Najat Abdulrazzaq Hasan --- Mohammed Hasan Al Baghdadi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2015 Volume: 14 Issue: 1 Pages: 108-113
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT : BACKGROUND: Clopidogrel, an adenosine diphosphate receptor blocker, is widely used as an adjunctive antiplatelet therapy in coronary disease and percutaneous coronary stenting. It appears to be a safe drug with few occurrences of liver side-effects that usually resolved after drug withdrawal.OBJECTIVE: The goal of this study was to investigate whether the co-administration of atorvastatin could aggravate the hepatic - toxicity of clopidogrel.PATIENTS AND METHODS: Eighty patients with coronary disease were included in this study. All patients received a dose of 75 mg/day of clopidogrel. Forty patients group A with recent treatment (˂ 3 months) of clopidogrel; other forty patients group B with (˃ 1 year) treatment of clopidogrel. Liver function tests were measured and studied at baseline (clopidogrel without atorvastatin) and at 2, 4, 6 weeks of clopidogrel with atorvastatin (40 mg/day) afterwards.RESULTS: Liver function tests with co-therapy showed high significant elevation in mean serum total alkaline phosphatase (P˂0.001), significant decrease (P˂ 0.05) in mean serum gamma-glutamyl transferase ,significant elevation (P˂ 0.05) in mean serum direct bilirubin and insignificant elevation (P˃0.05) in mean serum total bilirubin , whereas the results appeared within normal range in mean serum levels of alanine aminotransferase, aspartate aminotransferase ,glutamate dehydrogenase -1,and total protein .CONCLUSION: Combination of atorvastatin and clopidogrel may induce hepatic injury cholestatic type resulting from abnormal bile flow caused by either drugs or its metabolites.KEYWORDS: clopidogrel; atorvastatin; liver function tests.

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