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Article
Substituted Polyitaconicacid with Different Amines as Biodegradable Polymers.

Authors: Huda S.H. --- Jassem M.S. --- Firyal M.A فريال محمد علي السلامي
Journal: Journal of College of Education مجلة كلية التربية ISSN: 18120380 Year: 2011 Issue: 6 Pages: 366-377
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

New biodegradable poly itaconic acid which substituted withdifferent primary amines such as 4-aminopyridine,2-aminopyrimidine, 2-amino naphthol, amoxilline, cephalexine.All the prepared polymers were characterized by IR.,UV.Spectroscopy, thermal analysis, chemical tests, C.H.N analysis andphysical properties were studied, and the intrinsic viscosities weredetermined at 30ºC.The swelling % of the prepared polymers were calculated. Weconcluded from all the results that the inserted different units as apendant groups which enhanced the biodegradable andbiocompatible behaviors of the prepared polymers.

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Article
Preparation of Condensed Polymers of Sulfonated Aminoacids with Benzidine.
تحضير البوليمرات التكاثفية للحوامض الامينية المسلفنة مع البنزدين

Authors: Firyal M.A فريال محمد علي السلامي --- Amel A.A امل عبد الامير --- Khudheyer G.K. خضير جواد كاظم
Journal: Journal of College of Education مجلة كلية التربية ISSN: 18120380 Year: 2011 Issue: 6 Pages: 333-343
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

In this paper many new condensed polymers were synthesized from reactionof sulfonated amino acids such as histidine, alanine and asparging with benzidine. Thenew condensed polymers were characterized by FTIR and UV. spectroscopy.The physical properties were measured, and the swelling % were studied withdifferent non solvents. The intrinsic viscosity was measured by Ostwald-viscometer,using DMF as a solvent The TGA and DTA were studied. The high softening pointswere measured for all condensed polymers which have higher than 240 OC. Thecontrolled release were studied in different pH values at 37 0C.The inserted moiety units of sulfonated aminoacids could enhanced thebiocompatibility, bioactivity and biodegradability properties for these preparedbiomaterials polymers, and the incorporation of aminoacids through backbone of thecondensed polymers.

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Article
Synthesis of N- Drug MaleamideChitosan Drug polymers
تحضير بوليمرات استر- امايد من بوليمر الكيتوسان الطبيعي

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Abstract

In this research a new prodrug chitosan maleamide derivatives weresynthesis via reaction of amino group of chitosan with maleic anhydride thenconverted to its corresponding acyl chloride, of the chitosan maleatederivative (A1) was reacted with different drug-NH2 (A2-A5) such asprocaine, cephalexin, amoxicillin, and 4-aminoantipyrine.which could havepotential use as a natural drug delivery system as a sustain release throughhydrolysis of amide attachment in different pH values such as in acidic orbasic medium. These derivatives were characterized by FTIR and 1H-NMRspectroscopies. Controlled drug release was studied using UV. Spectroscopyat λmax 270nm gave a constant swelling percentage were measured indicatedcontrolling release with other advantages and to minimize the toxicity and theside effect. Thermal analysis such as TGA and DSC were studied indicatedthe thermally stableprodrug polymers.

(( ائي م (( ك اللام (( امض الماليئ (( ع ح (( ان م (( ل الكيتوس (( ن تفاع (( دة م (( ة الجدي (( اعدات الادوي (( ث مس (( ذا البح (( ي ه (( ر ف (( حضل (((( ذي يحم ((( ال (A تق( 1 (((( ا مش ((( ائي مكون (((( ك اللام ((( امض المالليت ((( ع ح (((( ان م ((( ة للكيتوس (((( ة الاميني ((( ل المجموع ((( ت ض ((( ع بع ((( ة م ((( ت مفاعلت ((( ذي تم ((( ل ال ((( امض المقاب ((( د الح ((( ى كلوري ((( ا ال ((( ن تحويله ((( رة يمك ((( يلية ح ((( ة كاربوكس ((( مجموعي ((( الت (A5-A ايرين ( 2 ((( ي ب ((( و انت ((( لين، 4-أمين ((( ين، اموكس ((( ائين، سيفالكس ((( ل البروك ((( ة مث ((( ة المختلف ((( ة الاميني ((( الادويية ((( ي دوال حامض ((( د، ف ((( ة الامي (( ائي لمجموع ((( ل الم ((( لال التحل (( ن خ ((( دوائيالمحكم م ((( رر ال (( ة التح ((( ة كأنظم ((( ا القابلي (( لهت ((( عة تح ((( ة الاش ((( رة بمطيافي ((( ة المحض ((( تقات البوليمري ((( ت المش ((( ة 37 م. شخص ((( ة بدرج ((( ية وقاعدي ((( ة حامض ((( مختلفف ((( تخدام طي ((( م باس ((( دوائي المحك ((( رر ال ((( رع التح ((( ت س ((( ي. ودرس ((( ووي المغناطيس ((( رنين الن ((( ة ال ((( راء ومطيافي ((( الحمة (( رة اربع (( ة لفت (( ز ثابت (( ي بتراكي (( رر دوائ (( ى تح (( ث اعط (( حي nm وجي 270 (( ول م (( د ط (( جية عن (( وق البنفس (( عة ف (( الاشرى ((( د الاخ ((( ى الفوائ ((( افة ال ((( دواء اض ((( ئ لل ((( رر البطي ((( د التح ((( ي تؤك ((( ة والت ((( اخ المئوي ((( بة الانتف ((( ت نس ((( ام، ودرس ((( ايج ((( وزني والمس ((( راري ال ((( ل الح ((( ل التحل ((( ة مث ((( ل الحراري ((( ت التحالي ((( ة، ودرس ((( ار الجانبي ((( مية والمض ((( ل الس ((( لتقليالمسعري التفاضلي الذي يدل على الثباتية الحرارية للبوليمرات الدوائية المساعدة.

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