research centers


Search results: Found 2

Listing 1 - 2 of 2
Sort by

Article
Simultaneous determination of paracetamol and cephalexin binary mixtures by using derivative spectrophotometry and H-point standard addition methods

Authors: Asraa A. Al-Abaas --- Firyal Waly Askar --- Khaleda, H. Al-saidi
Journal: Journal of College of Education مجلة كلية التربية ISSN: 18120380 Year: 2010 Issue: 1 Pages: 43-58
Publisher: Al-Mustansyriah University الجامعة المستنصرية

Loading...
Loading...
Abstract

Two methods are applied for simultaneous determination of paracetamol (para) and cephalexin (ceph) in combined mixtures, derivative spectrophotometric technique and H-Point standard addition method (HPSAM) spectrophotometry. The first procedure is based on the use of the, second derivative ( 2D ) and used the suitable wave lengths at zero crossing at valley 250.5 and 290.2 nm for determination paracetamol and cephalexin respectively.. Calibration graphs were established for 2-60 mg/L for Para and 2-70 mg/L for ceph in binary mixture. The proposed method were successfully applied to the determination of these drugs in synthetic mixtures, linearity was excellent (r2>0.999) over the concentration tested (2–60 mg/L) with good precision and accuracy. Recoveries were good (>98%) with limits of detection of 1 and 1.5 mg/L ,(%R.S.D.= 0.757- 1.207) for para and ceph, respectively.. The second procedure HPSAM was applied to the simultaneous determination of Para and ceph. respectively. (HPSAM) method was based on the difference in the absorbance of para and ceph.at choosing wavelengths (265 and 257 nm). Results of the analysis of the different mixtures in the proposed system revealed a dynamic range of 2-35 and 2-50 mg/L, with limits of detection of 2 and 3 mg/L for para and ceph, respectively. The relative error are between -0.605-1.64 and -1.230-1.43, for para and ceph respectively. RSD% 0.151-1.775 for para and ceph, respectively. The two methods were found to be precise, accurate, simple and rapid..

Keywords


Article
Synthesis of New Some Imidazole Derivatives Containing β-Lactam Ring
تحضير بعض مشتقات الاميدازول الجديدة التي تحتوي حلقة-βلاكتام

Authors: Firyal Waly Askar فريال ولي عسكر --- Rana Abid Ali رنا عبد علي --- Thanaa Mahdi Al-Mouamin ثناء مهدي المؤمن
Journal: Baghdad Science Journal مجلة بغداد للعلوم ISSN: 20788665 24117986 Year: 2016 Volume: 13 Issue: 2ملحق ابحاث المؤتمر الوطني الثاني للكيمياء Pages: 307-316
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

In this work 5-methylene-yl - (2-methy –oxazole-4-one) (1H) imidazole (1) were synthesized from the reaction of L-Histidine with acetic anhydride and which converted to the of 5-methylene-yl-(2-methyl 3-amino imidazole-4-one)-1H-imidazole (2) by reaction with hydrazine hydrate. Schiff bases (3-6) were synthesized from the reaction of compound (2) with different aromatic aldehyde. Reaction of compounds (3-6) with chloroacetyl chloride gives azetidinone one derivatives (7-10). These compounds were characterized by FT-IR and some of them with 1H-NMR and 13C-NMR spectroscopy.

في هذا البحث تم تحضير 5-مثيلينيل -2-(2-مثي اوكسازول -4-ون)-1-ايميدازول (1) من تفاعل ل-هستدين مع حامض الخليك اللامائي والذي تم تحويله الى 5- مثيلين- يل (2-مثيل -3- امينو اميدازول-4-ون)-1-ايميدازول (2) عن طريق التفاعل مع هيدرات الهيدرازين.تم تحضير قواعد شيف (3-6) من تفاعل المركب (2) معالديهايداتاروماتية مختلفة.تم الحصول على مركبات ازيتيدينون مختلفة (7-10) من تفاعل قواعد شيف المحضرة(3-6) مع كلوريد الكلورواسيتيل.شخصت المركبات المحضرة بواسطة FT-IR وبعضها بـ 1H-NMR وبعضها بالمطياف 13C-NMR .

Listing 1 - 2 of 2
Sort by
Narrow your search

Resource type

article (2)


Language

English (2)


Year
From To Submit

2016 (1)

2010 (1)