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Measurement of extracellular fluid compartment volume using inulin

Author: Ghassan T. Al-Ani *M.Sc. غسان ثابت العاني
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 / 24108057 Year: 2008 Volume: 50 Issue: 3 Pages: 391-394
Publisher: Baghdad University جامعة بغداد


Background:There is a need to find methods to assess the size of the extracellular fluid (ECF) volumewithout involving radioactive tracers. For this purpose, the simple delusion method was usedto measure the ECF in rabbits and the inulin which is a polysaccharide was used as a markerof ECF measurement.Methods:18 male rabbits were used in this study. 8 of these animals were bilaterally nephroctomizedto calculate the exact time to get diffusion equilibrium time after a bolus dose of inulin at adose of 25mg/kg of a solution of inulin 10 mg/ml. intravenously. The blood samples weretaken after 1, 15, 45, 60, 90, 120, and 180 min.Results:ECF volume was about 144.5 to 149.7 ml/kg depending on the inulin concentrationchanging with time because the equilibrium time of inulin and the ECF could not beobtained to the end of the experiment.Conclusion:The inulin takes a space in the body fluids differ than the true ECF volume. It is better to usethe term "inulin space" to reflect such measurements rather than the ECF volume.Key words: inulin, extracellular volume.

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