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•Oxidative stress and Lipid peroxidation in patients with Multiple

Authors: Halla G. AL-Gebouri --- Hedef EL-Yassin
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2011 Volume: 4 no 2 Issue: 10 Pages: 1073-1076
Publisher: Kerbala University جامعة كربلاء

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Abstract

Back ground: multiple sclerosis (MS) has a much higher incidence among Caucasians that in any other race. Females are much more susceptible than males and white females living in colder weather areas are much more susceptible than those living in warmer areas. Oxidative stress means an alteration in the delicate balance between free radicals and the scavenging capacity of antioxidant enzymes in favor of free radicals in the body system.Objective: To evaluate and compare the antioxidants and lipid peroxidation in patients with MS and healthy control.Patients and method: The study has included thirty patients with MS (16 females and 14 males) and thirty healthy subjects. The subjects were selected from people attending the out patients clinic of Baghdad Teaching Hospital in Medical City. Laboratory parameters included were: uric acid, albumin, and caeruloplasmin, total thaiol, malondiaaldehyde (MDA) and peroxinitrate (ONOO¯).Results: MDA and ONOO¯ levels in serum of patients with MS were significantly higher than in the control group. While the levels of GSH, CP, albumin, uric acid, iron, copper and zinc in serum of patients with MS were significantly lower than in healthy control.Conclusion: Oxidative stress may have a role in the pathophysiology of multiple sclerosis syndromes.

Keywords

lipidperoxide --- ONOO¯ --- GSH --- CP --- uric acid --- albumin --- multiple sclerosis


Article
Uric Acid and Endothelial Dysfunction in Essential Hypertension

Authors: Halla G. Al-Gebouri --- Zainab Abdul Razak Al- Sharifi
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2010 Volume: 3 no.3, 4 Issue: 7 Pages: 914-918
Publisher: Kerbala University جامعة كربلاء

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Abstract

Background: Uric acid (UA) can stimulate the biosynthesis of c-reactive protein (CRP), and that might be one of the mechanisms underlying the endothelial dysfunction. Several studies showed an independent link between UA and CRP suggest that chronic exposure to mild hyperuricemia may be a factor that contributes to micro inflammation and raised CRP in individuals with essential hypertension.
Aim: The aim of this study is to investigate the relationship between the serum uric acid, CRP , total cholesterol and endothelial dysfunction in patient with essential hypertension .
Patients and methods: Twenty patients with essential hypertension and fifteen apparently subjects matched for age and weight have been included in this study, Uric acid and total cholesterol were determined by enzymatic methods. High sensitivity C-reactive protein (HsCRP) enzyme immunoassay for the quantitative determination in human serum was used.
Results: The data obtained showed that the serum levels of uric acid, CRP and total cholesterol were significantly higher in patients with hypertension than in healthy controls.
Conclusion: The conclusion was that hyperuricemia in individuals with essential hypertension is associated with endothelial dysfunction. This association, which is independent of classical risk factors like total cholesterol, CRP, supports the hypothesis that UA plays a significant role in this alteration in humans.

Keywords


Article
Lipid Peroxidation and Oxidative Stress in Patients with Fibromyalgia Syndrome

Authors: Halla G. AL-Gebouri --- Zuhair AL-Mashhadani --- Mohammad H. AL-Osami* --- Kisma M. Turki
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 1 Pages: 101-105
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACK GROUND:Fibromyalgia (FMS) is a common, chronic widespread pain syndrome usually associated with other somatic and psychologic symptoms including fatigue, sleep disturbances, cognitive difficulties Oxidative stress means an alteration in the delicate balance between free radicals and the scavenging capacity of antioxidant enzymes in favor of free radical in the body system.OBJECTIVE:To evaluate and compare the antioxidants and lipid peroxidation in patients with fibromyalgia and healthy control.PATIENTS AND METHOD;The study has included sixty patients with FMS (40 females and 20 males) and thirty healthy subjects. The subjects were selected from people attending the out patients clinic in Medical City- Baghdad Teaching Hospital- Rheumatology& Rehabilitation Consultation Unit. Laboratory parameters included: uric acid,albumin,caeruloplasmin,total thaiol,malondiaaldehyde(MDA) and peroxinitrate(ONOO¯ ).RESULTS:MDA and uric acid levels in serum of patients with fibromyalgia were significantly higher than in the control group. While the levels of ONOO¯ GSH,CP,albumin in serum of patients with fibromyalgia were significantly lower than in healthy control.CONCLUSION:oxidative stress may have a role in the pathophysiology of fibromyalgia syndrome.

Keywords

lipidperoxide --- ONOO¯ --- GSH --- CP --- uricacid --- albumin --- fibromyalgia.

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