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Article
The Association Between Leptin with Lipid Profile and Troponin in Acute Myocardial Infarction Patients

Authors: lmmmA Esmaeel Ibrahim --- Hadef Dhafer EL-Yassin --- Hamid Kareem Sachit AL-Janabi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 3 Pages: 332-338
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT :BACKGROUND:Fat cells, are the cells that primarily compose adipose tissue, specialized in storing energy as fat. Adipose tissue also serves as an important endocrine organ by producing hormones such as leptin, resistin, and the cytokine. Leptin is a protein hormone that plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. Acute Myocardial Infarction (AMI), is the interruption of blood supply to part of the heart, causing some heart cells to die.OBJECTIVE:To investigate the levels of leptin and its effect on lipid profile level in Acute Myocardial Infarction.SUBJECTS AND METHODS:The study included 50 patients with Acute Myocardial Infarction and forty healthy subject as control group. leptin and lipid profile levels were measured.RESULTS:The levels of leptin were significantly elevated in female patients group with(p=0.002), in male patients group(p=0.018) and in total patients group (p=0.001), cholesterol and LDL-C were significantly elevated with (p<0.001), while HDL-C was significantly lower with (p<0.001), there was positive correlation between leptin with , cholesterol LDL-C, triglyceride and VLDL, and there was negative correlation between leptin with HDL in acute myocardial infarction patients.CONCLUSION:Leptin negatively correlated with HDL and positively correlated with triglyceride and LDL this relation make this hormone act as atherosclerotic factor.


Article
Level of Resistin in Acute Myocardial Infarction Patients and its Relation to Lipid profile and Cardic Troponin I

Authors: lmmmA Esmaeel Ibrahim --- Hadef Dhafer EL-Yassin --- Hamid Kareem Sachit AL-Janabi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 4 Pages: 430-435
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Inflammatory responses are involved in the initiation and progression of atherosclerotic plaques. Myocardial Infarction (MI) is most commonly due to occlusion of a coronary artery following the rupture of a vulnerable atherosclerotic plaque. It has been suggested that the adipose tissue may play an important role in mediating this chronic inflammatory process. Resistin is a cysteine-rich polypeptide that is expressed at relatively lower levels in human adipocytes but higher levels in macrophages. Troponin is found in cardiac muscle and used for diagnosis of AMI.OBJECTIVE:To investigate the level of resistin and its effect on lipid profile and Troponin I levels in acute myocardial infarction patients.SUBJECT AND METHODS:The study included 50 patients with AMI and forty healthy subjects as control group. In this study resistin , lipid profile and Troponin I were measured.RESULTS:The levels of resistin, cholesterol, LDL-C were significantly elevated with (p<0.001), while HDL-C was significantly lower with (p<0.001), there was positive correlation between resistin with cholesterol, LDL-C, triglyceride and VLDL, while there was negative correlation between resistin with HDL in acute myocardial infarction.CONCLUSION:There was a significant increase in resistin level, in acute myocardial infarction patients and this increase may be related to inflammation. Resistin negatively correlated with HDL and positively correlated with triglyceride and LDL this relationship makes us consider this hormone as possible atherosclerotic factor


Article
Level of Resistin in Acute Myocardial Infarcti on Patients and its Relation to Lipid profile and Cardic Troponin I

Authors: Ammal Esmaeel Ibrahim --- Hadef Dhafer EL-Yassin --- Hamid Kareem Sachit AL-Janabi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2010 Volume: 9 Issue: 4 Pages: 430-435
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Inflammatory responses are involved in the initiation and progression of atherosclerotic plaques.Myocardial Infarction (MI) is most commonly due to occlusion of a coronary artery following therupture of a vulnerable atherosclerotic plaque. It has been suggested that the adipose tissue mayplay an important role in mediating this chronic inflammatory process. Resistin is a cysteine-richpolypeptide that is expressed at relatively lower levels in human adipocytes but higher levels inmacrophages. Troponin is found in cardiac muscle and used for diagnosis of AMI.OBJECTIVE:To investigate the level of resistin and its effect on lipid profile and Troponin I levels in acutemyocardial infarction patients.SUBJECT AND METHODS:The study included 50 patients with AMI and forty healthy subjects as control group. In this studyresistin , lipid profile and Troponin I were measured.RESULTS:The levels of resistin, cholesterol, LDL-C were significantly elevated with (p<0.001), while HDLCwas significantly lower with (p<0.001), there was positive correlation between resistin withcholesterol, LDL-C, triglyceride and VLDL, while there was negative correlation betweenresistin with HDL in acute myocardial infarction.CONCLUSION:There was a significant increase in resistin level, in acute myocardial infarction patients and thisincrease may be related to inflammation. Resistin negatively correlated with HDL and positivelycorrelated with triglyceride and LDL this relationship makes us consider this hormone as possibleatherosclerotic factor


Article
The Correlation Between Insulin ,IL-6 and CRP in Acute Myocardial Infarction

Authors: lmmmA Esmaeel Ibrahim --- Hadef Dhafer EL-Yassin --- Hamid Kareem Sachit AL-Janabi*
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 4 Pages: 536-541
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Insulin is a hormone produced by the beta cells of the pancreas. Insulin is necessary for the uptake of glucose into all cells in the body other than the Brain. C reactive protein (CRP) is a main inflammatory factor that is produced by the liver during acute infection or inflammation and its concentration in plasma can increase as much as 1000-fold during injury and infection. Interleukin-6 (IL-6), a major regulatory proinflammatory cytokine, is produced by a variety of cells, including leukocytes, adipocytes, and endothelial cells, and acts on the liver to stimulate the production of a number of acute-phase proteins.OBJECTIVE:The present study was designed to examine the relationship between fasting plasma IL-6 and CRP concentrations and insulin action in acute myocardial infarction patients.SUBJECTS AND METHODS:The study included 50 patients with acute Myocardial infarction (AMI) and forty healthy subjects as control group. Levels of insulin, CRP and IL-6 were measured.RESULTS:The levels of insulin, IL-6 and CRP were significantly elevated in AMI patients with (p<0.001). There was positive correlation between insulin with CRP and IL-6 in acute myocardial infarction patients.CONCLUSION:The significant increase in insulin in AMI may be related to inflammation. Insulin positively correlated with inflammatory markers (CRP and IL-6)


Article
The Impact of Inflammation on Adiponectin, IL-6 and CRP in Acute Myocardial Infarction Patients

Authors: lmmmA Esmaeel Ibrahim --- Hadef Dhafer EL-Yassin --- Hamid Kareem Sachit AL-Janabi.
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: supplement Pages: 616-622
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Adipose tissue is increasingly recognized as a key regulator of energy balance, playing an active role in lipid storage and buffering, and synthesizing and secreting a wide range of endocrine products that may be directly involved in the pathogenesis of the complications associated with obesity. Adiponectin is adipocyte derivate hormone that has important effect as anti-inflammatory factor. Inflammation contributes across the spectrum of cardiovascular disease, including the earliest steps in atherogenesis. IL-6 is one of the most important mediators of fever and of the acute phase response. C-reactive protein (CRP) is a protein found in the blood, the levels of which rise in response to inflammation (an acute-phase protein). Myocardial Infarction (MI) or Acute Myocardial Infarction (AMI), is the interruption of blood supply to part of the heart, causing some heart cells to die.OBJECTIVE:To investigate the level of adiponectin and its effect on IL-6 and CRP in patients with Acute Myocardial infarction.SUBJECTS AND METHODS:The study included 50 patients with Acute Myocardial infarction and forty healthy subjects as control group. Levels of adiponectin , CRP and IL-6 were measured.RESULTS:The levels of adiponectin, IL-6 and CRP were significantly elevated with (p<0.001), there was negative correlation between adiponectin with CRP and IL-6 in acute myocardial infarction patients.CONCLUSION:The significant increase in adiponectin in AMI may be related to inflammation. Adiponectin inversely correlated with inflammatory marker (CRP and IL-6) so it has anti-inflammatory properties and that make us consider it as cardiovascular protective factor


Article
The Association between Adiponectin, Insulin and Troponin I in Patients with Acute Myocardial Infarction

Authors: Ammal Esmaeel Ibrahim --- Hadef Dhafer El-Yassin --- Hamid Kareem Sachit Al-Janabi
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2012 Volume: 15 Issue: 3 Pages: 15-22
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Adipose tissue is increasingly recognized as a key regulator of energy balance, playing an active role in lipid storage and buffering, and synthesizing and secreting a wide range of endocrine products that may be directly involved in the pathogenesis of the complications associated with obesity the most important adiposcyte deviated hormone is adiponectin. Insulin is a hormone that is central to regulating the energy and glucose metabolism in the body. Troponin is a complex of three regulatory proteins that is integral to muscle contraction in skeletal and cardiac muscle.This study was conducted during the period from Decenber2009 to April 2010, includes fifty patients with Acut Myocardial Infarction (AMI) were admitted to Cardiac Care Unit (CCU) at Medical City Teaching Hospital and Ibn –ALbetar Hospital in Baghdad. Levels of adiponectin, insulin and troponin were measured by ELISA method.The levels of adiponectin, insulin and troponin were significantly elevated with (p<0.001), A negatively significant correlation between adiponectin with insulin and troponin in acute myocardial infarction patients was found.Adiponectin was negatively associated with insulin in patients with AMI

النسيج الدهني يُعْرَفُ على نحو متزايد كمنظّم رئيسي لميزانِ الطاقةِ، يَلْعبُ دوراً نشيطاً في خزنِ الدهون و ويفرز تشكيلة واسعة من المُنتَجاتِ الإفرازيةِ التي قَدْ تُشتَركُ في النشوء المرضي لكثير مِنْ التعقيداتِ المرتبطة بصورة مباشرة بالسمنةِ من اهم المركبات التي يفرزها النسيج الدهني هرمون adiponectin. الأنسيولين هو الهورمون الذي ينظيم أيضِ الجلوكوزَ والطاقةَ في الجسمِ. Troponin هو مركّب مِنْ ثلاثة بروتينِات تنظيم الإنكماشِ العضلي في العضلات الهيكليةِ والقلبيةِ.تَضمّنتْ الدراسةُ 50 مريضُ بالذبحة الصدرية اما المجموعة المسيطرة فقد تضمنت أربعون من الأشخاص الأصحاء. مستويات adiponectin والأنسيولينِ و troponin تم قياسهامستويات adiponectin والأنسولين و troponin كانت مرتفة بشكل معنوي (p <0.001)، كان هناك إرتباطُ سلبي ُبين adiponectin والأنسولين و troponin في مرضى الذبحةّ الصدرية.وجود زيادة معنوية في مستويات adiponectin، في مرضى الذبحةّ الصدرية وهذه قَد تكون مُتَعَلّقة بالالتهاب. هنالك علاقة عكسية بينadiponectin والأنسولين.

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