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QUANTIFICATION OF PAIN THRESHOLD IN PARKINSON’S DISEASE

Authors: Aqeel K Hatim عقيل كريم حاتم --- Munther T Hamzah منذر طاهر حمزة --- Hasan A Hasan حسن عزيز حسن --- Zaki N Hasan زكي نوح حسن
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2012 Volume: 10 Issue: 1 Pages: 83-86
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

BackgroundParkinson's disease (PD) is the second most common degenerative neurologic disorder after Alzheimer’s disease. Pain is one of the major clinical symptoms of Parkinson's disease, occurring in 50-83% of patients. Pathways mediating pain are complex and include basal ganglia and thalamocortical-basalganglia circuits.ObjectiveTo quantitatively assess pain perception in Parkinson disease patients, by determining pain threshold in patients with and without pain through using electrical stimulation.MethodsA cross sectional observational study recruiting 18 patients with a clinical diagnosis of Parkinson disease and healthy controls from the neurologic unit in Al-Kadhimiya Teaching Hospital in Baghdad; between May 2010 to Jan 2011. There were 13 men and 5 women with a mean age of (66.5 ± 10.2 years). The control group includes 18 healthy subjects, [12 males/ 8 females] with a mean age of 56.6±6.74 years. Quantitative sensory testing was carried at the neurophysiology laboratory in Al-Kadhimiya hospital; using bipolar stimulating electrodes on the forearm, index finger, mid leg, and big toe.ResultsFourteen Out of 18 patients (77.7%) reported pain, while 4 (22.3%) had no pain. There was a highly significant statistical difference in electrical perception between the affected and unaffected side, and between Parkinson disease patients and the controls. There was no statistically significant difference between males and females [p =0.8248], and between patients with and those without pain [p =0.3279]. And between upper and lower limbs on the affected side [p =0.1412], and body side involvement whether right or left in both the patients and controls.ConclusionChronic pain is present in 77.7% of Parkinson disease. Patients with Parkinson disease had lower pain threshold compared to controls. The affected side had lower pain threshold. The left or right body side and gender had no effect on pain threshold.Key worldsParkinson disease, Pain

Keywords

Parkinson disease --- Pain


Article
OBSERVING THE OUTCOME OF USING NEUROAID [MLC 601] ON A SAMPLE OF IRAQI STROKE PATIENTS

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Abstract

Background:Stroke is one of the major causes of morbidity and mortality throughout the world, and carries greater economic costs. [MLC 601] originates from Traditional Chinese Medicine approved in 7 countries as drug that can aids post-stroke recovery.Objective:To assess [MLC 601] efficacy in improving outcomes of Iraqi patients’ stroke.Methods:Two hundreds ischemic stroke patients and 17 intracerebral hemorrhage patients were participated in this study; they took [MLC601] at the onset of their disease for 3 months and were assessed monthly for the motor power using modified Rankin scale mRs scale, speech, and visual field assessments.Results:mRs grade [4-5] were changed from (zero out of 159) at onset to (89 out of 55) at first month and to 98 out of 134 ischemic stroke patients after 3 months; also mRs grade [4-5] were changed from (1 out of 17) at onset to (12 out of 17) at first month and to 12 out of 17 intracerebral hemorrhage patients after 3 months. In 44% of the enrolled patients with aphasia were improved. Visual field assessments showed improvement in 43% of the patients with homonymous heminopia after 3 months [MLC 601] treatment.Conclusion:[MLC 601] is associated with improvement in all post stroke disabilities and placebo controlled trial is crucial to assess the benefit of it.Key worlds:Stroke, intracerebral hemorrhage, MLC 601, NeuroAid

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