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Protective Role Of Honey on The Dorsal Surface of The Tongue of Methotrexate Treated Rats (Histological and Immunohistochemical Study)

Authors: Ali Sultan Al-Refai --- Hassan Ali Al-Barazenchy --- Hanan Abdulla Abdulqader --- Ameera Kamal Khalil
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2016 Volume: 13 Issue: 3 Pages: 670 -678
Publisher: Babylon University جامعة بابل

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Abstract

The most common side effect of chemotherapy is oral mucositis and the effective treatment is considered important in cancer patient. This study was aimed to evaluate the effect of honey as a treatment for dorsaltongue mucositis caused by the methotrexate.Forty Albino rats were usedin the present study and grouped randomly into control and study groups(20 animals each). The rats in the control group were divided randomly into two groups: 10 animals were treated by distilled water and 10 animals were treated by (2.5gm/kg) honey two times daily for eight days using gavage needle, and a physiological salinewas intraperitoneally injected at day four for all the animals. In the study group, they were intraperitoneally injectedby60 mg/kg of methotrexate at day four and the animals were treated in the same way like control group. At day eight, all the animals were sacrificed;and a cross section fromthe tongue was removed for histopathological and immunohistochemical (Ki-67 and Bcl-2 immunolabeling) analysis.Honey can partially protect the tongue from methotrexate induced cytotoxicity, and attenuate the associated injury. Ki-67 immune expression was non significantly increased (p>0.05), but Bcl-2 immune expression was significantly increased in (p<0.05) in comparison with methotrexate treated group.Honeycan produce protection against methotrexate induced dorsal tongue mucositis.Flavonoids and phenolic compounds in honey can accelerate the healing process by its anti-oxidant and free radical scavenging properties.

Keywords

Honey --- Mucositis --- Chemotherapy --- ki-67 --- Bcl-2

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