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Article
Effect of Periodontal Therapy on Serum and Salivary Interleukin-2 Levels in Chronic Periodontitis

Author: Haween T. Nanakaly
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2016 Volume: 28 Issue: 2 Pages: 73-78
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Interleukine-2 is a multifunctional cytokine, considered a central regulator of host resistance against avariety of pathogens and has been recently demonstrated to exert an active role in the pathogenesis of periodontaldiseases. The purpose of this study was to evaluate the effect of scaling and root planning on level of IL-2 in serumand saliva of patients with chronic generalized periodontitis, in relation to clinical parameters.Materials and Methods: A total of 50 subjects were enrolled, of which 25 had chronic generalized periodontitis and25 periodontally healthy subjects as control. The clinical parameters included: gingival index, pocket probing depth,clinical attachment level and bleeding on probing. The level of IL-2 in serum and saliva was estimated by usingenzyme linked immunosorbent assay kit at baseline and after 4 weeks of the treatment (scaling and root planning).Results: Mean IL-2 level in serum and saliva of patients with chronic periodontitis at baseline(382.15± 96.02 and501.82± 88.08 ng/L) were significantly higher than in controls (10.98± 3.04 and 20.89 ± 7.16 ng/L; p=0.001) respectively.Post-periodontal therapy, IL-2 levels in serum and saliva increased significantly (534.18 ± 127.70 and 710.87 ± 198.15;P= 0.001.) compared to basal levels, as well as to control group (p< 0.001). Statistically significant positive associationwas found between salivary IL-2 level and the pocket depth in the chronic periodontitis post therapy (r = 0.45, p=0.02).Conclusion: Short-term nonsurgical periodontal therapy leads to in a significant improvement in clinical periodontalparameters and a marked increase in IL-2 levels


Article
Interleukine-6 Level in Saliva of Patients with Chronic Periodontitis: A Case-Control Study

Author: Haween T. Nanakaly
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2016 Volume: 28 Issue: 1 Pages: 103-108
Publisher: Baghdad University جامعة بغداد

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Abstract

Background:Periodontal diseases are infectious diseases in which periodontalpathogens trigger chronicinflammatory and immune responses. Interleukine-6 is a multifunctional cytokine playing a central role ininflammation and tissue injury.The aim of the study IS to determine the level of Interleukin-6(IL-6) in saliva of patientswith chronic periodontitis compared to healthy subjects.Materials and Methods:The total subjects of the present study is 60, divided into 3 groups; 20 patients with chronicperiodontitis with pocket depth(PD ≥4 mm)(group I), 20 patients with pocket depth(PD <4 mm) with clinicalattachment loss (group II), and 20 healthy controls with pocket probing depth (PPD ≤ 3 mm) without clinicalattachment loss (group III). Un-stimulated salivary sample was taken from each subject and was investigated for thepresence of Interleukine-6by using Enzyme‑linked Immunosorbent Assay (ELISA) technology.Results:Mean IL-6 levels in saliva in patients with chronic periodontitis (98.40 ± 18.44 ng/L)was significantly higher thanin controls (11.67 ± 3.32; p=0.001). Also a significant difference in IL-6 levels in saliva was observed between the PPD ≥4 mm and PPD < 4 mm groups and between PPD ≥ 4 mm and control groups, as well as statistically significantdifferences were observed between PPD < 4 mm and control groups (P < 0.001).Conclusion:The Interleukine-6 level in saliva can be considered as one of inflammatory biomarker indicators ofseverity of periodontitis


Article
Effect of non surgical periodontal treatment on TNF-α levels in serum of patients with chronic periodontitis
تأثير علاج اللثة غير الجراحي على مستويات TNF-α في مصل المرضى الذين يعانون من التهاب اللثة المزمن

Authors: Haween T. Nanakaly --- Sazan Sartip Abdulhameed
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2016 Volume: 20 Issue: 1 Pages: 1167-1174
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Chronic periodontitis is a multifactorial inflammatory disease characterized by destruction of tooth supporting tissues. Tumor necrosis factor-α, a key inflammatory cytokine, plays an important role in periodontal destruction. This study aimed to analyze the effect of non-surgical periodontal treatment on tumor necrosis factor-α levels in serum of patient with chronic periodontitis (with and without using chlorhexidine 0.2% mouthwash).Methods: A total of 44 patients with moderate to severe localized chronic periodontitis were divided into: Group I (n=22) without using of chlorhexidine mouthwash and Group II (n=22) with 0.2% chlorhexidine mouthwash. Serum samples collected from each subjectsat baseline and four weeks after scaling and root planning treatment were quantified fortumor necrosis factor-α levels using ELISA technique.Results: The mean concentration of TNF-α were significantly reduced one month after treatment in sera of patients with chronic periodontitis for group I when compared to its mean concentration before treatment (P <0.05), while in group II a highly significant reduction after one month treatment (P <0.001) was observed.Conclusion: The effect of non-surgical periodontal therapy with chlorohexidine mouth wash showed more reduction in the levels of serum tumor necrosis factor-α.

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