research centers


Search results: Found 7

Listing 1 - 7 of 7
Sort by

Article
The Effect of Chromium in The Pathogenesis of Insulin Resistance in Preeclampsia

Author: Haydar Hashim Al-Shalah
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2016 Volume: 13 Issue: 3 Pages: 596 -602
Publisher: Babylon University جامعة بابل

Loading...
Loading...
Abstract

Insulin resistance is well established to be related with preeclampsia. The action of insulin in human appears to be potentiated by chromium. The aim of present study was assessment of chromium level in the development of insulin resistance in preeclampsia and hence its pathogenesis . This case control study was achieved on subjects recruited from Babylon Teaching Hospital for Obstetric & Gynecology during the period between September 2013 till October 2015, included 90 pregnant women, 45 of them identified with preeclampsia in the third trimester and other 45 were apparently healthy pregnant women taken as a controls.Chromium concentrations was measured by Atomic Absorption Spectrophotometry. Fasting insulin was estimated by Enzyme Linked Flouroscent Immune-Assay (ELFA) technique and fasting plasma glucose concentration by glucose oxidase method. Insulin resistance was calculated by homeostatic model assessment(HOMA)using mathematical equation. The results of present study showed no significant difference in fasting plasma glucose concentrations between patients and controls (P value >0.05),while there were a significant differences in chromium concentration level and insulin resistance between two groups (P value <0.05).However, there was no correlation between insulin resistance in patients with preeclampsia and low chromium level (r= 0.101, p=0.508). The present study concluded that low chromium level has no impact on the development of insulin resistance in preeclampsia.


Article
Procalcitonin as a Mediator of Chronic Inflammation in Obese Women with PCOS

Authors: Nadia Mudher Al-Hilli --- Haydar Hashim Al-Shalah
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2010 Volume: 7 Issue: 3-4 Pages: 505-510
Publisher: Babylon University جامعة بابل

Loading...
Loading...
Abstract

Background: Polycystic ovary syndrome (PCOS), a common reproductive endocrine condition characterized by hyperandrogenism, chronic anovulation, and obesity. Obesity is associated with a low-grade inflammation of white adipose tissue resulting from chronic activation of the innate immune system and can subsequently lead to insulin resistance, impaired glucose tolerance and even diabetes. In the last few years, adipose tissue emerged as an important source of proinflammatory mediators including TNF- , IL-6, and procalcitonin. Objective: to investigate procalcitonin as a marker of chronic inflammation in obese women with PCOS. Method: a case control study conducted from January 2010 till July 2010. The study involved 20 women with PCOS and 20 control women matched for age and BMI. Waist to hip ratio was measured and blood was drawn from patients and controls and serum levels of FSH, LH, prolactin, testosterone and procalcitonin were estimated by VIDAS using VIDAS kits provided by Biomerieux (France). Student t test was used to evaluate the difference in serum procalcitonin level between the two groups. Results: compared with control group, patients with PCOS had a significantly higher waist to hip ratio (mean 0.95 ± 0.2 versus 0.8 ± 0.13). Serum procalcitonin level was significantly higher in women with PCOS compared to control group (1.43 ± 0.42 ng/mL Vs 0.19 ± 0.13 ng/mL) P value was < 0.0001. Serum levels of FSH, LH, prolactin and testosterone all were significantly higher in women with PCOS than in the control group (P value < 0.05). Conclusion: The increase in low-grade chronic inflammation in women with PCOS is primarily associated with increased central fat excess. Procalcitonin represents a novel marker of the inflammatory activity of body fat in PCOS.

Keywords


Article
The Association of Serum Androgen Levels with Preeclampsia

Authors: Nadia Mudher Al-Hilli --- Haydar Hashim Al-Shalah
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2010 Volume: 7 Issue: 1-2 Pages: 58-66
Publisher: Babylon University جامعة بابل

Loading...
Loading...
Abstract

Background: Preeclampsia is a major cause of morbidity and mortality during pregnancy. Several independent investigators have demonstrated the association of androgens with hypertension. Objective:To determine whether maternal serum levels of testosterone and dehydroepiandrosterone sulphate DHEA-S, are higher in patients with preeclampsia than in matched normotensive control subjects. Method: Case control study included 29 subjects in the 3rd trimester of pregnancy with documented preeclampsia (including 10 cases of mild and19 cases of severe preeclampsia) and 20 healthy normotensive women in the third trimester of pregnancy used as control group and for comparative purpose another 13 patients with gestational hypertension were also included in our study. All cases had singleton pregnancies. Cases of polycystic ovary syndrome (PCOS), diabetes, chronic hypertension and chronic systemic diseases such as lupus and patients using steroid drugs were excluded. Serum levels of total testosterone were measured using testosterone enzyme immunoassay test kit, Biocheck (USA), while dehydroepiandrosterone sulfate (DHEA-S) was measured using DHEA-S enzyme immunoassay test kit, DRG (USA, Germany). Results: Student t-test was used to analyze the difference in androgen levels between the different groups. Serum total testosterone level was significantly higher in patients with severe pre-eclampsia compared to control group (0.41ng/mL versus 0.31ng/mL, P value 0.005), while no significant difference was found between cases of mild and severe pre-eclampsia. Again no significant difference was found when comparing patients with mild pre-eclampsia with control group and cases of gestational hypertension with control group. Serum level of dehydroepiandrosterone sulfate (DHEA-S) was significantly higher in patients with severe pre-eclampsia compared to patients with mild pre-eclampsia (1.03 µg/mL versus 0.32 µg/mL; P value 0.005) and when compared with control group (1.03 µg/mL versus 0.59 µg/mL; P value 0.02), while the level was not significantly higher when comparing cases of mild pre-eclampsia with control group and cases of gestational hypertension with control group. Conclusion: Levels of total testosterone and dehydroepiandrosterone sulfate (DHEA-S) were significantly higher in women with severe preeclampsia than in normotensive women. The levels of these androgens were higher in women severe pre-eclampsia when compared to women with mild pre-eclampsia and those with gestational hypertension. This difference may indicate a role for androgens in the pathogenesis of preeclampsia and stimulates research in the potential role of anti-androgens in the management of preeclampsia.

Keywords


Article
Correlation of Fetuin A level with ECG types of Acute Myocardial Infarction

Authors: Haydar Hashim Al-Shalah --- Oday Al-Salihi --- Dina Ayed Mohammed
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2016 Volume: 13 Issue: 4 Pages: 750 -754
Publisher: Babylon University جامعة بابل

Loading...
Loading...
Abstract

Acute myocardial infarction is one of the commonest disease with serious complications and increasing morbidity and mortality. Coronary atherosclerosis plays a crucial role in the underlying pathophysiology. Fetuin-A is a protein which is closely linked with increased risk of cardiovascular disease, and secreted mainly by the liver, produces subclinical inflammation and insulin resistance. This study was aimed to evaluate the association of serum fetuin A level with ECG types of acute myocardial infarction.This is a case–control study included 88 subjects divided into two groups; 44 patients with acute myocardial infarction,36 of them with STEMI and 7 with NSTEMI. The other 44 were apparently healthy individuals taken as a control. Serum fetuin-A levels were measured by using ELISA technique. There was significant differences in serum fetuin-A levels between patients and control, (p value ≤ 0.05).The mean differences between serum fetuin-A levels and both type of AMI (STEMI and NSTEMI),were also significant(p value ≤ 0.05) where higher values observed in STEMI.This study concluded thatfetuin-A level was significantly correlated with type of AMI and higher values of fetuin-A were observed in STEMI .

Keywords

Fetuin-A --- AMI --- ELISA technique --- STEMI --- NSTEMI --- ECG


Article
The Association of Serum Iron, Zinc, and Copper Levels with Preeclampsia

Authors: Haydar Hashim Al-Shalah --- Nadia Mudher Al-Hilli --- Mohammed Abbas Hasan
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 4 Pages: 1027 -1036
Publisher: Babylon University جامعة بابل

Loading...
Loading...
Abstract

Preeclampsia is defined as hypertension associated with proteinuria arise for the first time after the 20th week of gestation in a previously normotensive woman & resolve completely by the 6th postpartum week. In the present study trace and ultratrace elements iron, zinc, and copper were estimated to know the role of them in pathogenesis of pre-eclampsia. Case control study included 120 women, sixty of them were patients diagnosed with preeclampsia in the third trimester and the other sixty were healthy pregnant women (controls) in the third trimester. Serum levels of copper was measured by using graphite furnace atomic absorption spectrophotometer technique. While total serum iron and zinc concentrations were measured by using spectrophotometric method. The results were expressed as mean ± standard error of mean. A P value of < 0.01 was considered to be statistically significant. The levels of serum zinc and copper were significantly lower in patients with pre-eclampsia compared to control groups. While the concentration of total serum iron was significantly higher in patients with pre-eclampsia compared to control group. As conclusion, alteration in the serum levels of trace and ultratrace elements could contribute to the pathogenesis of PE.


Article
The Role of Potassium to Creatinine Ratio as Diagnostic Test in Pre-Eclampsia

Authors: Gaith Kamil Jawad --- Haydar Hashim Al-Shalah --- Milal Muhammad Al-Jeborry
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2017 Volume: 14 Issue: 3 Pages: 518 -524
Publisher: Babylon University جامعة بابل

Loading...
Loading...
Abstract

Pre-eclampsia is defined as hypertension associated with proteinuria arising de novo after the120th week of gestation in a previously normotensive woman and resolving. completely by the 26th postpartum week. It is a major cause of morbidity and mortality during pregnancy. There are many ways to diagnose the disease, based on clinical diagnosis and conduct some tests; measurement of the amount of protein in urine sample that had been collected for a period of twenty-four hours. Evaluate urinary K+ to creatinine ratio as a diagnostic and screening test in PE. Our study was carried out at Babylon Teaching Hospital for Gynecology and Pediatrics, in Babylon Province, Hilla City from February-August- 2016. The total number of all cases was 88,44 among them women with normal pregnancy, 44 cases with PE.Every patient was sent for urinary K+ and creatinine in spot urine which both were determined by ion selective electrode and Moorehead and Briggs derived O-Cresol Pthalien Complexone method respectively, and the ratio K+ to creatinine were calculated. Data are given as mean ± SD, and t-test were used as statistical method to test the result. Urinary K+/creatinine ratio was significantly higher in patients with pre-eclampsia compared to control groups (P value <0.01). The sensitivity of urinary K+/creatinine ratio to detect PE was (77%) while, its specificity was (68%). Urinary K+/creatinine ratio is significantly increase in preeclamptic women.


Article
The Impact of Electrolytes in Pathogenesis of Simple Febrile Convulsions

Author: Azad Farhan Hawas, Haydar Hashim Al‑Shalah, Adnan Handhil Al‑Jothary
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2018 Volume: 15 Issue: 1 Pages: 12-15
Publisher: Babylon University جامعة بابل

Loading...
Loading...
Abstract

Febrile convulsion is one of the most common seizure disturbances in children with an approximate rate of 2%–5%, febrile seizures (FSs)occur between the age of 6 and 60 months with a 38°C or higher temperature, and they do not result from central nervous system infectionor any metabolic imbalance, and these seizures occur when a history of prior FSs is absent. In this study, 150 children whose ages rangedbetween 6 and 60 months were divided into three groups: Group A included 50 children with febrile convulsions, Group B included 50 childrenhaving fever without convulsion, and Group C included 50 healthy children with nonfebrile convulsions. In the present study, the serum sodiumand potassium were significantly lower in cases of febrile convulsion than the control groups, whereas no significant changes were shown inthe levels of ionic calcium in the cases of febrile convulsion when compared with the control groups. These findings revealed that there is acorrelation between differences of serum sodium and potassium in simple febrile convulsion.

Listing 1 - 7 of 7
Sort by
Narrow your search

Resource type

article (7)


Language

English (7)


Year
From To Submit

2018 (1)

2017 (1)

2016 (2)

2015 (1)

2010 (2)