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Article
Metabolic Syndrome in the Spectrum of Hair Grayness
المتلازمة الايضية في طيف مشيب الشعر

Author: Hayder R. Al-Hamamy حيدر رؤوف الحمامي
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2012 Volume: 54 Issue: 2 Pages: 182-184
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: hair graying is an aging sign; it is associated with ischemic heart disease. Metabolic syndrome often associates with increased risk for atherosclerotic arterial disease.Objective: To test retrospectively the association between onset of hair graying and risk of metabolic syndrome.Methods: Four hundred and eighty one gray hair individuals, with no history of atherosclerotic diseases were included. The individuals have been divided into metabolic syndrome and control groups. Each individual was asked about the decade (2nd-6th) of onset of hair grayness.Results: Patients with metabolic syndrome had peak onset of hair grayness in the 4th decade which was statistically higher than the control group (p values= 0.045). While the peak onset in the control group was in the 5th decade which was different from the metabolic syndrome group (p-value = 0.024). The difference was not significant in the 2nd, 3rd and 6th decades of life.Conclusion: Patients with metabolic syndrome had an earlier age of onset of hair grayness.Keywords: hair grayness, metabolic syndrome.

الخلفية : ظهور المشيب هي علامة لتقدم السن وجدت انها تقترن بالقصور الشرياني . المتلازمة الايضية هي مايطلق على مجموعة عوامل الخطورة التي غالبا ماتزيد من مخاطر الاصابة بتصلب الشرايين.الهدف : اختبار الاقتران بين العمر الذي يبدأ به ظهور الشيب والعرضة للاصابة بالمتلازمة الايضية.الطرق : اربعمائة وواحد وثمانون شخص اشيب الشعر اشتركوا في الدراسة ممن لم يعانوا مسبقا من اي من امراض تصلب الشرايين . المشاركون قسموا الى مجموعتين, مجموعة الضبط ومجموعة المتلازمة الايضية , وكل شخص من كلا المجموعتين سؤل عن العقد (العقد الثاني الى العقد السادس) من العمر الذي لاحظ فيه لاول مرة ظهور الشيب في شعره.النتائج: مرضى المتلازمة الايضية اظهروا ذروة ظهور المشيب في العقد الرابع مع وجود فرق مهم احصائيا مع مجموعة الضبط, قيمة P كانت 0,045. اما مجموعة الضبط فاظهرت ذروة ظهور المشيب في العقد الخامس وكان الفرق مهم احصائيا مع مجموعة المتلازمة الايضية, قيمة P كانت 0.024. الفرق لم يكن مهم احصائيا بين المجموعتين في العقود الثاني والثالث والسادس.الاستنتاج : المرضى المصابين بالمتلازمة الايضية يبدأ عندهم مشيب الشعر بعمر اقل من سواهم .مفتاح الكلمات: مشيب الشعر, المتلازمة الايضية


Article
Quality of Life Assessment in Iraqi Patients with Acne Vulgaris and Psoriasis

Author: Hayder R Al-Hamamy*, Sarmad Yahya Abood**
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2017 Volume: 16 Issue: 4 Pages: 345-348
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Skin diseases may affect daily lives of individuals and their psychological and social relationships. Appropriate measurement systems are required to evaluate the impact of the disease on the quality of life. The Dermatology Life Quality Index (DLQI) is an important and commonly used dermatology specific quality of life instrument.OBJECTIVE: To assess the quality of life in 2 common dermatological disorders (acne and psoriasis) in Iraqi patients attending dermatological outpatient clinic, Baghdad Teaching Hospital.PATIENTS AND METHODS:A case series study of 400 patients with 2 dermatological diseases (acne and psoriasis); 200 patients for each disease were evaluated. Information related to socio-demographic data and disease severity were recorded and quality of life was assessed by means of the Dermatology Life Quality Index.RESULTS:The DLQI of patients with acne and psoriasis were comparable; 7.71+/-4.64 and 8.52+/-4.48 respectively. In patients with acne the DLQI was significantly affected by higher level of education P=0.002, also in unmarried patients P=0.0001. Increased disease severity also affected DLQI (P=0.003). In patients with psoriasis the only factor which was associated with a higher DLQI was female gender.CONCLUSION:Acne and psoriasis affect significantly the DLQI of patients. DLQI is a good indicator of the impact of the disease on the life of the patient.


Article
Chronic ulcerative Cutaneous Vasculitis of the legs Clinical and histopathological study

Authors: Husam A. Salman --- Hayder R. Al-Hamamy --- Thamir A. Hamed
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2009 Volume: 51 Issue: 1 Pages: 34-38
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Cutaneous small vessel vasculitis characterized by necrosis and inflammation of upper dermal blood vessels. It presents with ulcers and systemic manifestations after extensive acute onset. Many patients have a form of cutaneous vasculitis that presents with chronic painful ulcerations & purpuras involving the ankles without systemic manifestations, with some similarity in clinical presentation to livedoid vasculopathy. Patients and Methods: Thirteen patients were seen in the Department of Dermatology and Venereology, Baghdad Teaching Hospital, for a period extending from January 2004 to March 2005. They were evaluated clinically, histopathologically and other laboratory studies. In addition, evaluation of the clinical response to prednisolone 0.5mg/kg/day and azathioprine150mg/day was done.
Results: Thirteen patients were included in this study; eight females and five males, with male to female ratio of 1:1.6. Their ages ranged between 26-66 years with a mean ±SD of 42 ± 13.8 years. The duration of the disease ranged from 0.5 – 18 years with a mean ±SD of 38 ± 59.2 months.The clinical examination revealed multiple oval punched out ulcers, with an indurated base, and surrounded by a zone of erythema; affecting mainly the ankles and dorsa of feet. Histopathological evaluation showed upper dermal vessels' wall necrosis, fibrinoid deposition, obliteration of the lumen, extravasation of red blood cells, endothelial cells swelling with perivascular and vascular wall infiltration mainly by mononuclear cells.The treatment was started with prednisolone & azathioprine. The ulcers healed completely with residual hyperpigmentation - hypopigmentation, atrophy and scars within 10-15 weeks Conclusions: Chronic ulcerative cutaneous vasculitis is often a neglected and misdiagnosed variant of vasulitis. Histologically it has vascuiltic features, and clinically looks like livedoid vasculopathy.


Article
Topical Methotrexate for Treatment of Psoriasis: Formulation and Clinical Implications

Authors: Hayder R.Al-Hamamy --- Mohammed R. I. Ghazal --- Murtadha S. Jabur
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2010 Volume: 52 Issue: 1 Pages: 32-36
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: To test effectiveness and safety of topical methotrexate 0.5%gel and to introduce new formula of methotrexate gel using suitable media for delivery.
Patients and Methods: The clinical work was performed at the Department of Dermatology and Venereology in Baghdad Teaching Hospital during the period from January 2008 to October 2008. While preparation of formula was performed in the laboratories of the Department of Pharmacology-College of Medicine-University of Baghdad. Patients were divided in to two groups according to the type of treatment, group (I) 32 patients treated with methotrexate 0.5% gel and group(II) (placebo group) included 33 patients treated with placebo gel.
Results: A total of 65 patients with limited plaque psoriasis were included in this study. For the MTX group the mean PASI score before treatment was 7.07 while at 2, 4, 6 and 8 weeks treatment, it was decreased to 5.17, 3.93, 3.07 and 2.35 respectively. At eight weeks treatment 25(78%) patients achieved good response (reduction in PASI score 50%), while 5(15.6%) patients achieved partial response (reduction in PASI score 25-49%) and 2(6.25%) patients had poor response (reduction in PASI score >25%). For placebo group the pretreatment mean PASI score was 7.12 and after 2, 4, 6 and 8 weeks treatment it became 6.32, 6.07, 5.99 and 6.2 respectively. Clinically the response of the patients to placebo gel at 8 weeks treatment was partial in 10(30.3%) patients and poor in 23(69.7%) patients while no patients achieved good response.
Conclusions: MTX 0.5% gel is effective treatment option for plaque psoriasis and also appears to be safe treatment since side effects were transient, limited and reduced with continuation of therapy.
Key words: Psoriasis and methotrexate 0.5% gel

Keywords


Article
Treatment of Vitiligo Patients with Narrow Band Ultraviolet Light -B and Associated Predictive Factors (A Prospective Interventional Therapeutic Study)

Author: Hayder R. Al-Hamamy* , Sabeeh A. Al-Mashhadani **, Manar G. Aziz
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2018 Volume: 17 Issue: 1 Pages: 13-21
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND: Vitiligo is a common dermatological disease with a great psychological impact on the life of individual. Narrow band ultraviolet B phototherapy has been used successfully for the treatment of vitiligo with variable results.OBJECTIVE: To assess the response to NB UVB and to identify factors that could predict the response to therapy.Patients and methods: This study is an interventional prospective therapeutic study, had been conducted in the Department of Dermatology and Venereology - Baghdad Teaching Hospital extending from October 2013 to October 2014. Thirty two patients with vitiligo were included in the study , the ages ranged from 8- 35 (18.84±7.86) years, 22 (68.8%) females and 10 (31.2%) males, the body surface area of vitiligo ranged from 2- 60%( 23.8 ± 16.66 ), full history and physical examination , assessment of skin phenotype , daily life quality index before and after completing the 48 sessions. Narrow band phototherapy was given twice weekly, recording of the body surface area of vitiligo was done before the treatment and every 16 sessions till the end of 48 sessions. Documentation of the first response session for every patient, calculation of the total percent of reduction , the main predictive factors and the development of any side effect had been recorded.RESULTS: First response session ranged from 3- 20 (10th ± 4.37) ,the response of patients according to the degree of regimentation was as the following: 3 (9.37%) patients had excellent response, 6 (18.75%) patients had good response , 14 (43.75%) patients had moderate response and 9 (28.12%) patients had poor response. The age of patients and negative hair involvement had a statistically significant correlation to the total percent of reduction. The face was the area of maximum response , The side effects were tolerable and no patient discontinued the treatment due to the side effects. Daily life quality index showed a statistically significant reduction at the end of treatment.CONCLUSION: Narrow band is an effective treatment for vitiligo with few side effects. Age of the patients and absence of hair involvement are favorable predictive features. The face was the area of maximum response.


Article
Metabolic Syndrome in the Spectrum of Hair Graying
المتلازمة الايضية في نطاق مشيب الشعر

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Abstract

Background: Hair graying is an aging sign that was found to be associated with several systemic diseases like ischemic heart disease, osteopenia, and autoimmune diseases. Metabolic syndrome was applied to the clustering of risk factors that often associate with increased risk for atherosclerotic cardiovascular disease. Aim of Study: Our work aimed to test retrospectively the association between onset of hair graying and risk of metabolic syndrome. Patients & Methods: Four hundred and eighty one gray hair individuals, with no history of any type of atherosclerotic disease, participated in the study. The participants were divided into two groups according to the presence or absence of criteria of metabolic syndrome into control and metabolic syndrome groups, and each individual in both groups was asked about the decade (2nd-6th) when he/she firstly noticed that he/she had a gray hair. A comparison was made regarding the age of onset of graying between the two groups. Results: There was a significant difference in decades between individuals with metabolic syndrome and the control group and was found in the 4th and 5th decade of life (P =0.045 & 0.024 respectively) while the difference was not significant in the 2nd, 3rd and 6th decades of life. The mean age of onset of hair graying in metabolic syndrome was 36.207 ± 8.30 year and the control group was 38.434 ±8.31 year, there is also a significant difference between the two groups (P value=0.003). Conclusion: patients with metabolic syndrome have an earlier age of onset of gray hair.

اساس الدراسة:ظهور المشيب هي علامة لتقدم السن وجدت انها تقترن بالعديد من الامراض الجهازية كالقصور الشرياني للقلب ونخر العظام والامراض المناعية. المتلازمة الايضية هي مايطلق على مجموعة عوامل الخطورة التي غالبا ماتزيد من مخاطر الاصابة بتصلب الشرايين. الهدف: اختبار الاقتران بين العمر الذي يبدأ به ظهور الشيب والعرضة للإصابة بالمتلازمة الايضية. الطرق: اربعمائة وواحد وثمانون شخص اشيب الشعر اشتركوا في الدراسة ممن لم يعانوا مسبقا من اي من امراض تصلب الشرايين .المشاركون كانوا من المرضى الراقدين في الردهات الجراحية والباطنية والمراجعين للعيادة الاستشارية للأمراض الجلدية والزهرية في مستشفى بغداد التعليمي. الدراسة امتدت من كانون الاول 2016 ولغاية مايس2017. المشاركون قسموا الى مجموعتين ,على اساس وجود مواصفات المتلازمة الايضية فيهم والتي تلاحظ بالفحصين السريري والمختبري , مجموعة الضبط ومجموعة المتلازمة الايضية , وكل شخص من كلا المجموعتين سؤل عن العمر الذي لاحظ فيه لأول مرة ظهور الشيب في شعره واجاب باختيار واحدة من خمس حقبات تمثل عقود الحياة الممتدة من العقد الثاني الى العقد السادس. واجريت المقارنة بين المجموعتين على اساس عمر الظهور الاول للشيب. النتائج: وقد اظهرت تلك الدراسة فرق مهم احصائيا بين المجموعتين مجموعة الضبط ومجموعة المتلازمة الايضية في العقدين الرابع والخامس من الحياة وقيمة P كانت 0,045 و 0,024 بالتتابع. اما الفروق بين المجموعتين للعقود الثانية والثالثة والسادسة فلم تكن ذو مغزى احصائي. معدل عمر ظهور المشيب ± الانحراف المعياري لمجموعة المتلازمة الايضية كان 36,207 سنة ± 8,3 بينما مجموعة الضبط ممن لم تظهر لديهم مواصفات المتلازمة الايضي فالمعدل ± الانحراف المعياري لديهم كان 38,343 سنة ± وقيمة P بين المعدلين كانت 0,003 اي ان المصابين بالمتلازمة الايضية يظر لديهم مشيب الشعر بعمر اقل.الاستنتاج: المرضى المصابين بالمتلازمة الايضية يبدأ عندهم مشيب الشعر بعمر اقل من سواهم.


Article
Immunoglobulins assessment (IgE,G,A,M) in some Iraqi patients with acute and chronic urticaria
تقيم الكلوبيولينات المناعية (M.A,G,IgE) في بعض المرضى العراقيين المصابين بالارتيكاريا الحادة والمزمنة

Authors: Mayida H. Al-Mousawi ميادة حسين الموسوي --- Talib Abdalla Hussein طالب عبد الله حسين --- Hayder R. Al-Hamamy حيدر رؤوف الحمامي
Journal: Baghdad Science Journal مجلة بغداد للعلوم ISSN: 20788665 24117986 Year: 2010 Volume: 7 Issue: 4 Pages: 1362-1365
Publisher: Baghdad University جامعة بغداد

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Abstract

60 patients diagnosed as having urticaria were included in the study ; 30 patients were effected with acute urticaria and 30 patients were affected with chronic urticaria. In addition, 30 healthy adult volunteers were selected as control group .The patients and control groups sera were examined with enzyme linked immunosorbent assay ( ELISA) to detect total level IgE and radial immunodiffusion (RID) to detect levels of IgG , IgA and IgM . The total level of IgE in acute urticaria ( 1.45±0.13) IU/mL and chronic urticaria (2.12 ± 0.10) IU/mL patients were significantly higher than the control groups ( 0.85 ± 0.10)IU/mL (p<0.05). The level of IgG in acute urticaria ( 12.5± 0.42) g/L and chronic (13.16±0.40) g/L patients , IgA in acute (2.5±0.2)g/L and chronic (2.39±0.19)g/L patients , and IgM in acute (1.75±0.11)g/L and chronic (1.47 ±0.07)g/L , patients were also significantly higher the control groups ( 9.79± 0.81) g/L,(1.63±0.14)g/L and (1.19±0.07) g/L respectively .The level of IgE was higher in the chronic urticaria patients than the acute urticaria stressing the importance of type-I hypersensitivity reaction in chronic urticaria .While the level of IgM was significantly higher in the acute urticaria patients than the chronic urticaria which may suggest that some cases of acute urticaria were caused by acute infections .

تضمنت هذه الدراسة تشخيص (60) مريضاً مصابين بالارتيكاريا ، منهم (30) مريضاً يعانون من الارتيكاريا الحادة و ( 30) مريضاً يعانون من الارتيكاريا المزمنة ، اضافة الى (30) من المتطوعين البالغين الاصحاء اختيروا كمجموعة سيطرة . تم فحص مصل المرضى ومجموعة السيطرة بأختبار الامتزاز المناعي المرتبط بالانزيم (ELISA) لتحديد المستوى الكلي للـ IgE والانتشار المناعي الشعاعي (RID) لتحديد مستويات IgM , IgA , IgG . المستوى الكلي للـ IgE في مرضى الارتيكاريا الحادة (0.13±1.45) وحدة دولية /مل وفي مرضى الارتيكاريا المزمنة (0.10±2.12) وحدة دولية / مل ارتفع معنوياً مقارنة بمجموعة السيطرة (0.10± 0.85) وحدة دولية / مل (p<0.05) . أن مستوى IgG في مرضى الارتيكاريا الحادة (0.42±12.5) غرام/لتر ومرضى الارتيكاريا المزمنة (0.40±13.16)غرام/لتر ، IgA في مرضى الارتيكاريا الحادة (0.2±2.5)غرام/لتر وفي مرضى المزمنة(0.19±2.39)غرام/لتر ،وIgMفي مرضى الحادة (0.11±1.75) غرام /لتر وفي مرضى المزمنة (0.07±1.47)غرام/لتر كذلك ارتفع معنوياً مقارنة بمجموعة السيطرة (0.81±9.79) غرام/لتر ، (0.14±1.63) غرام و(0.07±1.19) غرام/لتر علي التوالي . مستوى الـIgE أرتفع في مرضى الارتيكاريا المزمنة مقارنة بالارتيكاريا الحادة ليبين اهمية تفاعل فرط الحساسية النوع الاول في الاريتكاريا المزمنة . بينما مستوى الـ IgM ارتفع معنوياً في مرضى الاريتكاريا الحادة مقارنة بالاريتكاريا المزمنة يوحي بان بعض حالات الارتيكاريا الحادة قد تحدث بفعل الاخماج الحادة .


Article
Evaluation the effect of NB–UVB phototherapy on thyroid function in sera of vitiligo patients
تقييم تأثير المعالجة الضوئية بواسطة الاشعة فوق بنفسجية الضيقة النطاق نوع ب على وظيفة الغدة الدرقية في امصال مرضى البهاق

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Abstract

AbstractBackground: Vitiligo is a relatively common dermatologic finding observed since ancient times. The cause of this disease is unknown yet. Narrow-band ultraviolet B (NB-UVB) is an emerging, promising phototherapy for vitiligo. Methods: A total of 31 patients with vitiligo and 32 control subjects were the participant of the present study. Vitiligo patients were received NB-UVB treatment for three days weekly. T3, T4 and TSH were assayed in each sample using radioimmunoassay technique. Results: There was a significant difference in T3 level in the patients with vitiligo before treatment compared with its level in the control group (P=0.018), but no significant differences were found in T4 and TSH levels. When the comparison of these parameters levels were done according the gender within each group, no significant difference was observed. The results of the treatment on the measured hormones indicated that this type of treatment has no effect on the level of T3, T4 and TSH in vitiligo patients. Conclusion: On the bases of current study results, NB-UVB seems to be considered as a suitable therapeutic treatment of vitiligo as far as on thyroid function.

الخلاصةيعتبر البهاق من الامراض الجلدية الشائعة نسبيا. سبب هذا المرض غير معروف لحد الان. تعتبر المعالجة بواسطة الاشعة البنفسجية ضيقة النطاق نوع ب من المعالجات الواعدة للبهاق. بلغ اجمالي مرضى البهاق في هذه الدراسة 31 مرضيا مع مشاركة 32شخصا كعينات سيطرة. تلقى مرضى البهاق العلاج بالاشعة فوق البنفسجية ضيقة النطاق نوع ب ثلاث مرات اسبوعيا. و تم قياس تراكيز T3 و T4 و TSH لكل عينة باستخدام تقنية Raidoimmunoasssy .اظهرت النتائج وجود فرق معنوي في مستوى T3 لدى مرضى البهاق عند مقارنتهم مع مجموعة السيطرة(P=0.018) بينما لم تظهر فروق معنوية في مستويات T4 و TSH . كما لم تلاحظ فروق معنوية عند مقارنة هذه المعايير بين مرضى البهاق و عينات السيطرة بالنظر الى جنسهم. بينت نتائج العلاج على الهرمونات المقاسة انه لا تأثير لهذا النوع من العلاج على مستويات هورمونات T3 و T4 و TSH على مرضى البهاق. على اساس نتائج هذه الدراسة يمكن اعتبار العلاج بالشعة فوق البنفسجية ضيقة النطاق نوع ب من العلاجات المناسبة لمرضى البهاق من دون تأثير على وظسفة الغدة الدرقية.

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